CYP3A4 and CYP2C9

Number of citations of the paper that reports this interaction (PubMedID 20215413)
47

Data Source:
BioGRID (pull down)

		CYP3A4	CYP2C9
Description		cytochrome P450 family 3 subfamily A member 4	cytochrome P450 family 2 subfamily C member 9
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Monooxygenase Activity Steroid Binding Iron Ion Binding Protein Binding Steroid Hydroxylase Activity Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Enzyme Binding Heme Binding Vitamin D3 25-hydroxylase Activity Caffeine Oxidase Activity Metal Ion Binding Quinine 3-monooxygenase Activity Testosterone 6-beta-hydroxylase Activity 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase Activity Anandamide 8,9 Epoxidase Activity Anandamide 11,12 Epoxidase Activity Anandamide 14,15 Epoxidase Activity Vitamin D 24-hydroxylase Activity Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity 1,8-cineole 2-exo-monooxygenase Activity	Monooxygenase Activity Iron Ion Binding Arachidonate Epoxygenase Activity Steroid Hydroxylase Activity Arachidonate 14,15-epoxygenase Activity Arachidonate 11,12-epoxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen (S)-limonene 6-monooxygenase Activity (S)-limonene 7-monooxygenase Activity Heme Binding Caffeine Oxidase Activity Metal Ion Binding (R)-limonene 6-monooxygenase Activity Estrogen 2-hydroxylase Activity
	Biological Process	Lipid Hydroxylation Lipid Metabolic Process Fatty Acid Metabolic Process Steroid Biosynthetic Process Steroid Catabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Alkaloid Catabolic Process Monoterpenoid Metabolic Process Calcitriol Biosynthetic Process From Calciol Xenobiotic Catabolic Process Vitamin D Metabolic Process Vitamin D Catabolic Process Retinol Metabolic Process Retinoic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Aflatoxin Metabolic Process Oxidative Demethylation	Lipid Metabolic Process Terpenoid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Estrogen Metabolic Process Monoterpenoid Metabolic Process Arachidonate Metabolic Process Epoxygenase P450 Pathway Urea Metabolic Process Monocarboxylic Acid Metabolic Process Xenobiotic Catabolic Process Long-chain Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Oxidative Demethylation Organofluorine Metabolic Process Omega-hydroxylase P450 Pathway
Pathways		Phase I - Functionalization of compounds Xenobiotics Aflatoxin activation and detoxification Biosynthesis of maresin-like SPMs Aspirin ADME Atorvastatin ADME Prednisone ADME	Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of maresin-like SPMs Aspirin ADME
Drugs		Glutathione Isoniazid Pradefovir mesylate Casopitant Cobicistat Diacerein	Ferroheme C Diacerein Benzbromarone
Diseases
GWAS		Metabolic traits ( 21886157) Neonatal cytokine/chemokine levels (maternal genetic effect) ( 30134952) Pre-treatment viral load in HIV-1 infection ( 31219150) Sex hormone levels ( 26014426) Tacrolimus trough concentration in kidney transplant patients ( 29160300) Ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor ( 25935875)	Clopidogrel active metabolite levels ( 28207573) Dehydroepiandrosterone sulphate levels ( 21533175) Diastolic blood pressure ( 27841878) Glucocorticoid receptor gene expression in B-cell precursor acute lymphoblastic leukaemia ( 33002292) Immune response to smallpox vaccine (IL-6) ( 22542470) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Pulse pressure ( 27841878) Response to clopidogrel therapy ( 19706858 28207573) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284) Serum metabolite levels ( 23093944) Systolic blood pressure ( 27841878) Warfarin maintenance dose ( 26265036 18535201 23755828 20833655 19300499)
Interacting Genes		8 interacting genes: CYB5A CYP2C9 GK POR PRKACA PRKCA STUB1 UGT2B7	10 interacting genes: CDC37 CYP2D6 CYP3A4 ECSIT MAST1 POR RAB3D RNF32 STAMBP STAT5A
Entrez ID		1576	1559
HPRD ID		00484	03084
Ensembl ID		ENSG00000160868	ENSG00000138109
Uniprot IDs		P08684 Q6GRK0	P11712 S5RV20
PDB IDs		1TQN 1W0E 1W0F 1W0G 2J0D 2V0M 3NXU 3TJS 3UA1 4D6Z 4D75 4D78 4D7D 4I3Q 4I4G 4I4H 4K9T 4K9U 4K9V 4K9W 4K9X 4NY4 5A1P 5A1R 5G5J 5TE8 5VC0 5VCC 5VCD 5VCE 5VCG 6BCZ 6BD5 6BD6 6BD7 6BD8 6BDH 6BDI 6BDK 6BDM 6OO9 6OOA 6OOB 7KS8 7KSA 7KVH 7KVI 7KVJ 7KVK 7KVM 7KVN 7KVO 7KVP 7KVQ 7KVS 7LXL 7UAY 7UAZ 7UF9 7UFA 7UFB 7UFC 7UFD 7UFE 7UFF 8DYC 8EWD 8EWE 8EWL 8EWM 8EWN 8EWP 8EWQ 8EWR 8EWS 8EXB 8SO1 8SO2 9BBB 9COR 9COS 9COT 9COU 9COV 9COW 9COX 9COY	1OG2 1OG5 1R9O 4NZ2 5A5I 5A5J 5K7K 5W0C 5X23 5X24 5XXI 6VLT 7RL2 8VX0 8VZ7
Enriched GO Terms of Interacting Partners?		Regulation Of Hormone Levels Organofluorine Metabolic Process Endoplasmic Reticulum Demethylation Xenobiotic Metabolic Process Regulation Of Steroid Metabolic Process Enzyme Binding Intracellular Membrane-bounded Organelle Catabolic Process Estrogen Metabolic Process Regulation Of Hormone Metabolic Process Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Regulation Of Muscle System Process Regulation Of Biological Quality Cellular Response To Heat Transferase Activity Glycerol Kinase Activity Glycerol-3-phosphate Biosynthetic Process Regulation Of Lipid Metabolic Process Iron-cytochrome-c Reductase Activity Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitric Oxide Dioxygenase NAD(P)H Activity Nitrate Catabolic Process Response To Peptide Hormone Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Chaperone-mediated Protein Complex Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Steroid Biosynthetic Process Regulation Of Smoothened Signaling Pathway Positive Regulation Of Insulin Secretion Response To Heat Endoplasmic Reticulum Membrane (S)-limonene 7-monooxygenase Activity Lipid Metabolic Process Arachidonate 11,12-epoxygenase Activity (R)-limonene 6-monooxygenase Activity (S)-limonene 6-monooxygenase Activity Arachidonate 14,15-epoxygenase Activity Nitric Oxide Catabolic Process Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Positive Regulation Of Lipid Biosynthetic Process Proteasomal Protein Catabolic Process Positive Regulation Of Peptide Hormone Secretion Heme Binding Nitrate Metabolic Process NADPH-hemoprotein Reductase Activity Positive Regulation Of Peptide Secretion Renal System Process	Demethylation Anandamide 8,9 Epoxidase Activity Anandamide 11,12 Epoxidase Activity Anandamide 14,15 Epoxidase Activity Alkaloid Catabolic Process Monoterpenoid Metabolic Process Oxidative Demethylation Alkaloid Metabolic Process Xenobiotic Metabolic Process Intracellular Membrane-bounded Organelle Xenobiotic Catabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Estrogen Metabolic Process Long-chain Fatty Acid Biosynthetic Process Retinol Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Fatty Acid Metabolic Process Organic Acid Metabolic Process Isoquinoline Alkaloid Metabolic Process Negative Regulation Of Organofluorine Metabolic Process Secondary Metabolic Process Quinine 3-monooxygenase Activity 1,8-cineole 2-exo-monooxygenase Activity 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase Activity Iron-cytochrome-c Reductase Activity Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitric Oxide Dioxygenase NAD(P)H Activity Nitrate Catabolic Process Monooxygenase Activity Cell Surface Receptor Signaling Pathway Via JAK-STAT Retinoid Metabolic Process Diterpenoid Metabolic Process Cell Surface Receptor Signaling Pathway Via STAT Vitamin D 24-hydroxylase Activity Vitamin D3 25-hydroxylase Activity Nitric Oxide Catabolic Process Organofluorine Metabolic Process Positive Regulation Of Mast Cell Differentiation HSP90-CDC37 Chaperone Complex Terpenoid Metabolic Process Long-chain Fatty Acid Metabolic Process Isoprenoid Metabolic Process Regulation Of Biological Quality Coumarin Metabolic Process Vitamin D Biosynthetic Process Calcitriol Biosynthetic Process From Calciol Vitamin D Catabolic Process Nitrate Metabolic Process NADPH-hemoprotein Reductase Activity Regulation Of Steroid Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?