CYP3A4 and UGT2B7

Number of citations of the paper that reports this interaction (PubMedID 15486048)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		CYP3A4	UGT2B7
Description		cytochrome P450 family 3 subfamily A member 4	UDP glucuronosyltransferase family 2 member B7
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Monooxygenase Activity Steroid Binding Iron Ion Binding Protein Binding Steroid Hydroxylase Activity Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Enzyme Binding Heme Binding Vitamin D3 25-hydroxylase Activity Caffeine Oxidase Activity Metal Ion Binding Quinine 3-monooxygenase Activity Testosterone 6-beta-hydroxylase Activity 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase Activity Anandamide 8,9 Epoxidase Activity Anandamide 11,12 Epoxidase Activity Anandamide 14,15 Epoxidase Activity Vitamin D 24-hydroxylase Activity Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity 1,8-cineole 2-exo-monooxygenase Activity	Retinoic Acid Binding UDP-glycosyltransferase Activity Glucuronosyltransferase Activity Transferase Activity Glycosyltransferase Activity
	Biological Process	Lipid Hydroxylation Lipid Metabolic Process Fatty Acid Metabolic Process Steroid Biosynthetic Process Steroid Catabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Alkaloid Catabolic Process Monoterpenoid Metabolic Process Calcitriol Biosynthetic Process From Calciol Xenobiotic Catabolic Process Vitamin D Metabolic Process Vitamin D Catabolic Process Retinol Metabolic Process Retinoic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Aflatoxin Metabolic Process Oxidative Demethylation	Lipid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process
Pathways		Phase I - Functionalization of compounds Xenobiotics Aflatoxin activation and detoxification Biosynthesis of maresin-like SPMs Aspirin ADME Atorvastatin ADME Prednisone ADME	Glucuronidation Aspirin ADME Prednisone ADME
Drugs		Glutathione Isoniazid Pradefovir mesylate Casopitant Cobicistat Diacerein
Diseases
GWAS		Metabolic traits ( 21886157) Neonatal cytokine/chemokine levels (maternal genetic effect) ( 30134952) Pre-treatment viral load in HIV-1 infection ( 31219150) Sex hormone levels ( 26014426) Tacrolimus trough concentration in kidney transplant patients ( 29160300) Ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor ( 25935875)	AR-C124910XX levels in individuals with acute coronary syndromes treated with ticagrelor ( 25935875) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Estradiol levels ( 34255042) Gamma glutamyl transferase levels ( 33339817) Liver enzyme levels (alkaline phosphatase) ( 33972514) Obesity-related traits ( 23251661) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		8 interacting genes: CYB5A CYP2C9 GK POR PRKACA PRKCA STUB1 UGT2B7	2 interacting genes: CYP3A4 GABRA3
Entrez ID		1576	7364
HPRD ID		00484	02508
Ensembl ID		ENSG00000160868	ENSG00000171234
Uniprot IDs		P08684 Q6GRK0	E9PBP8 P16662
PDB IDs		1TQN 1W0E 1W0F 1W0G 2J0D 2V0M 3NXU 3TJS 3UA1 4D6Z 4D75 4D78 4D7D 4I3Q 4I4G 4I4H 4K9T 4K9U 4K9V 4K9W 4K9X 4NY4 5A1P 5A1R 5G5J 5TE8 5VC0 5VCC 5VCD 5VCE 5VCG 6BCZ 6BD5 6BD6 6BD7 6BD8 6BDH 6BDI 6BDK 6BDM 6OO9 6OOA 6OOB 7KS8 7KSA 7KVH 7KVI 7KVJ 7KVK 7KVM 7KVN 7KVO 7KVP 7KVQ 7KVS 7LXL 7UAY 7UAZ 7UF9 7UFA 7UFB 7UFC 7UFD 7UFE 7UFF 8DYC 8EWD 8EWE 8EWL 8EWM 8EWN 8EWP 8EWQ 8EWR 8EWS 8EXB 8SO1 8SO2 9BBB 9COR 9COS 9COT 9COU 9COV 9COW 9COX 9COY	2O6L
Enriched GO Terms of Interacting Partners?		Regulation Of Hormone Levels Organofluorine Metabolic Process Endoplasmic Reticulum Demethylation Xenobiotic Metabolic Process Regulation Of Steroid Metabolic Process Enzyme Binding Intracellular Membrane-bounded Organelle Catabolic Process Estrogen Metabolic Process Regulation Of Hormone Metabolic Process Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Regulation Of Muscle System Process Regulation Of Biological Quality Cellular Response To Heat Transferase Activity Glycerol Kinase Activity Glycerol-3-phosphate Biosynthetic Process Regulation Of Lipid Metabolic Process Iron-cytochrome-c Reductase Activity Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitric Oxide Dioxygenase NAD(P)H Activity Nitrate Catabolic Process Response To Peptide Hormone Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Chaperone-mediated Protein Complex Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Steroid Biosynthetic Process Regulation Of Smoothened Signaling Pathway Positive Regulation Of Insulin Secretion Response To Heat Endoplasmic Reticulum Membrane (S)-limonene 7-monooxygenase Activity Lipid Metabolic Process Arachidonate 11,12-epoxygenase Activity (R)-limonene 6-monooxygenase Activity (S)-limonene 6-monooxygenase Activity Arachidonate 14,15-epoxygenase Activity Nitric Oxide Catabolic Process Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Positive Regulation Of Lipid Biosynthetic Process Proteasomal Protein Catabolic Process Positive Regulation Of Peptide Hormone Secretion Heme Binding Nitrate Metabolic Process NADPH-hemoprotein Reductase Activity Positive Regulation Of Peptide Secretion Renal System Process	Vitamin D Biosynthetic Process Quinine 3-monooxygenase Activity Anandamide 8,9 Epoxidase Activity Calcitriol Biosynthetic Process From Calciol Vitamin D 24-hydroxylase Activity Anandamide 11,12 Epoxidase Activity Vitamin D Catabolic Process 1,8-cineole 2-exo-monooxygenase Activity Anandamide 14,15 Epoxidase Activity Alkaloid Catabolic Process Vitamin D3 25-hydroxylase Activity 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase Activity Caffeine Oxidase Activity Testosterone 6-beta-hydroxylase Activity Oxidative Demethylation Vitamin D3 Metabolic Process Retinoic Acid 4-hydroxylase Activity Monoterpenoid Metabolic Process Aflatoxin Metabolic Process Lipid Hydroxylation Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity Alkaloid Metabolic Process Demethylation Benzodiazepine Receptor Activity Vitamin D Metabolic Process Steroid Hydroxylase Activity Toxin Metabolic Process GABA-gated Chloride Ion Channel Activity GABA-A Receptor Activity GABA-A Receptor Complex Retinoic Acid Metabolic Process Xenobiotic Catabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Vitamin Metabolic Process Oxygen Binding Androgen Metabolic Process Steroid Catabolic Process Gamma-aminobutyric Acid Signaling Pathway Inhibitory Synapse Assembly Steroid Binding Postsynaptic Specialization Membrane Dendrite Membrane Synaptic Transmission, GABAergic Estrogen Metabolic Process Extracellular Ligand-gated Monoatomic Ion Channel Activity Long-chain Fatty Acid Biosynthetic Process Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Secondary Metabolic Process Retinol Metabolic Process
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