CDK9 and CDK7

Number of citations of the paper that reports this interaction (PMID 9184228)
47

Data Source:
BioGRID (biochemical, enzymatic study)

		CDK9	CDK7
Gene Name		cyclin-dependent kinase 9	cyclin-dependent kinase 7
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Transcription Elongation Factor Complex Positive Transcription Elongation Factor Complex B Membrane PML Body Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Holo TFIIH Complex Cytoplasm Mitochondrion Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Chromatin Binding Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II Carboxy-terminal Domain Kinase Activity SnRNA Binding Transcription Regulatory Region DNA Binding	Transcription Coactivator Activity Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity RNA Polymerase II Carboxy-terminal Domain Kinase Activity Androgen Receptor Binding
	Biological Process	DNA Repair Regulation Of DNA Repair Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Cell Proliferation Gene Expression Viral Process Regulation Of Histone Modification Replication Fork Arrest Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Negative Regulation Of Cell Cycle Arrest Cellular Response To Cytokine Stimulus	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Protein Phosphorylation Cell Cycle Arrest Cell Proliferation Gene Expression Viral Process Androgen Receptor Signaling Pathway Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Cell Division
Pathways		Loss of Function of TGFBR2 in Cancer Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription HIV Infection SMAD2/3 MH2 Domain Mutants in Cancer Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery TGFBR1 LBD Mutants in Cancer RNA Polymerase II Pre-transcription Events SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer HIV elongation arrest and recovery HIV Life Cycle Generic Transcription Pathway HIV Transcription Elongation TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Host Interactions of HIV factors Loss of Function of SMAD4 in Cancer Interactions of Tat with host cellular proteins TGFBR1 KD Mutants in Cancer Pausing and recovery of Tat-mediated HIV elongation Loss of Function of TGFBR1 in Cancer Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription of the HIV genome SMAD4 MH2 Domain Mutants in Cancer RNA Polymerase II Transcription Elongation	RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Tat-mediated elongation of the HIV-1 transcript Cyclin E associated events during G1/S transition Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in TC-NER NoRC negatively regulates rRNA expression G1/S Transition Mitotic G1-G1/S phases S Phase Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Global Genomic NER (GG-NER) RNA Polymerase II Transcription Initiation And Promoter Clearance Cyclin A:Cdk2-associated events at S phase entry Mitotic G2-G2/M phases Transcription of the HIV genome Nucleotide Excision Repair RNA Polymerase II Transcription RNA Polymerase I Transcription Initiation HIV Infection RNA Polymerase I Promoter Clearance Formation of the Early Elongation Complex G2/M Transition RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE Cyclin A/B1 associated events during G2/M transition RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Dual incision reaction in GG-NER RNA Polymerase I Transcription mRNA Capping RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination G1 Phase Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Cell Cycle, Mitotic Cyclin D associated events in G1 Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of incision complex in GG-NER RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation
Drugs			Phosphonothreonine Flavopiridol
Diseases
GWAS
Protein-Protein Interactions		56 interactors: ACTL6A AFF4 AR BCL10 BRCA1 CASK CCNK CCNT1 CCNT2 CDC34 CDC7 CDK5R1 CDK7 CTD CTDP1 CTDSPL CUL1 DHX30 FBXO25 GRN GTF2F1 HEXIM1 HEXIM2 HIST2H2BE HLTF HSPA1A HTATSF1 IL6ST MBP MDFIC MED21 MYBL2 NBN NFKB1 NR2E3 PIN1 POLR2A RB1 RCHY1 RELA RMND5B RN7SK SERPINH1 SKP1 SKP2 SMAD1 SMAD2 SMAD3 STAT3 STK36 SUPT5H TAF7 TP53 TRAF2 UBE2A ZMYM6	47 interactors: APP AR BRCA1 CCNA2 CCNB1 CCNH CDC37 CDK1 CDK2 CDK6 CDK9 CTD CTDP1 CUX1 E2F1 ERCC2 ERCC3 ESR1 GTF2E1 GTF2E2 GTF2H1 GTF2H2 GTF2H3 GTF2H5 HIST1H1A HLA-DQA1 HSD17B4 LASP1 MBP MCM7 MNAT1 NEK6 PCGF6 POLR2A POLR2B PRKCI RARA SMAD1 SRPK1 SRPK2 SUPT5H TAF7 TCEA1 THRA TP53 UBE2D1 VDR
Entrez ID		1025	1022
HPRD ID		16016	15993
Ensembl ID		ENSG00000136807	ENSG00000134058
Uniprot IDs		P50750	P50613
PDB IDs		1PF6 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY	1LG3 1PA8 1UA2 2HIC
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Viral Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Transcription, DNA-templated Positive Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Gene Expression RNA Metabolic Process Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Cell Cycle Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Cellular Process Transcription Initiation From RNA Polymerase II Promoter Cellular Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Viral Transcription Regulation Of Phosphorylation Regulation Of Protein Phosphorylation DNA-templated Transcription, Initiation Transcription Elongation From RNA Polymerase II Promoter Regulation Of Phosphorus Metabolic Process Biosynthetic Process Regulation Of Viral Transcription Cell Cycle Positive Regulation Of Viral Process DNA-templated Transcription, Elongation Response To Stimulus Regulation Of Cell Proliferation Negative Regulation Of Gene Expression Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Elongation Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Viral Process DNA-templated Transcription, Initiation Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Regulation Of Viral Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Viral Process Positive Regulation Of Cellular Biosynthetic Process 7-methylguanosine MRNA Capping Regulation Of Gene Expression Nucleotide-excision Repair 7-methylguanosine RNA Capping Regulation Of RNA Metabolic Process Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Response To DNA Damage Stimulus Transcription, DNA-templated Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process RNA Metabolic Process Regulation Of Cell Cycle Viral Process Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Transcription Elongation From RNA Polymerase I Promoter Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Metabolic Process Transcription From RNA Polymerase I Promoter Nucleotide-excision Repair, DNA Damage Removal Nitrogen Compound Metabolic Process DNA Repair Cellular Response To Stress Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Termination Of RNA Polymerase I Transcription
Tagcloud ?		affects associate bulk ccnk cdk12 cdk13 cdks ctd elongation far flag hct116 heptad implementing numerous paralog partner phosphorylate preferentially processing repeat reveals rna sec seq snorna super tagged tefb	arrested asynchronous biochemically carboxy cdc2 cip1 enter extracts inactivated machinery microtubule mitosis mitotic nocodazole p21waf1 p36 p62 polymerase polymerization prepared reconstituted repressed repression reproduced rescue sdi1 shutdown tfiid tfiih
Tagcloud (Difference) ?		affects associate bulk ccnk cdk12 cdk13 cdks ctd elongation far flag hct116 heptad implementing numerous paralog partner phosphorylate preferentially processing repeat reveals rna sec seq snorna super tagged tefb	arrested asynchronous biochemically carboxy cdc2 cip1 enter extracts inactivated machinery microtubule mitosis mitotic nocodazole p21waf1 p36 p62 polymerase polymerization prepared reconstituted repressed repression reproduced rescue sdi1 shutdown tfiid tfiih
Tagcloud (Intersection) ?