CDK7 and HSD17B4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		CDK7	HSD17B4
Description		cyclin dependent kinase 7	hydroxysteroid 17-beta dehydrogenase 4
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Transcription Factor TFIIH Core Complex Fibrillar Center Male Germ Cell Nucleus Nucleus Nucleoplasm Transcription Factor TFIIH Holo Complex Cytoplasm Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm CAK-ERCC2 Complex Transcription Factor TFIIK Complex	Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Kinase Activity Transferase Activity Protein Serine Kinase Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Kinase Activity	(3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Enoyl-CoA Hydratase Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Oxidoreductase Activity Lyase Activity Isomerase Activity 3-hydroxyacyl-CoA Dehydratase Activity 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA Hydratase Activity Protein Homodimerization Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity (3R)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity
	Biological Process	RNA Polymerase II Promoter Clearance DNA Repair Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Transcription Elongation By RNA Polymerase II DNA Damage Response Positive Regulation Of Transcription Elongation By RNA Polymerase II SnRNA Transcription By RNA Polymerase II Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Cell Division Regulation Of Cell Cycle Transcription Pausing By RNA Polymerase II RNA Polymerase II Transcription Initiation Surveillance Regulation Of G1/S Transition Of Mitotic Cell Cycle	Very Long-chain Fatty Acid Metabolic Process Osteoblast Differentiation Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Unsaturated Fatty Acid Biosynthetic Process Androgen Metabolic Process Estrogen Metabolic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Very Long-chain Fatty-acyl-CoA Metabolic Process Medium-chain Fatty-acyl-CoA Metabolic Process Long-chain Fatty Acid Biosynthetic Process Sertoli Cell Development Fatty Acid Derivative Biosynthetic Process
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE RUNX1 regulates transcription of genes involved in differentiation of HSCs	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol alpha-linolenic acid (ALA) metabolism Beta-oxidation of pristanoyl-CoA Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins
Drugs		Phosphonothreonine Alvocidib SNS-032 Seliciclib Trilaciclib	NADH (R)-3-hydroxydecanoyl-CoA
Diseases			Peroxisomal beta-oxidation enzyme deficiency, including: Acyl-CoA oxidase (ACOX) deficiency; D-bifunctional protein (DBP) deficiency; Perrault syndrome; Sterol carrier protein X (SCPx) deficiency; 2-Methylacyl-CoA racemase (AMCR) deficiency; Hypercholanemia
GWAS			Asthma ( 31959851) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) JT interval (sulfonylurea treatment interaction) ( 27958378) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) QT interval (sulfonylurea treatment interaction) ( 27958378) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		44 interacting genes: APP AR BRCA1 CCND2 CCNH CDK1 CDK2 CDK6 CEBPA CTDP1 CUX1 E2F1 ERCC2 ERCC3 ESR1 GTF2E1 GTF2E2 GTF2H1 GTF2H2 GTF2H3 GTF2H5 H1-1 HLA-DQA1 HSD17B4 HSPA5 LASP1 MBP MCM7 MNAT1 NEK6 PCGF6 POLR2B PRKCI RARA SMAD1 SRPK1 SRPK2 SUPT5H TAF7 TCEA1 THRA TP53 UBE2D1 VDR	9 interacting genes: ACTB BAK1 CASP9 CDK7 CEBPA MAPK8 NDRG1 SNCA TIAM1
Entrez ID		1022	3295
HPRD ID		15993	03514
Ensembl ID		ENSG00000134058	ENSG00000133835
Uniprot IDs		A0A0S2Z3F9 D6R9G1 D6RFL0 P50613	A0A0S2Z4J1 A0A2R8Y7L2 A0A804HK65 B2R659 B3KSP2 E7ET17 P51659
PDB IDs		1UA2 6O9L 6XBZ 6XD3 7B5O 7B5Q 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 8BVW 8BYQ 8GXQ 8GXS 8ORM 8P4Z 8P6V 8P6W 8P6X 8P6Y 8P6Z 8P70 8P71 8P72 8P73 8P74 8P75 8P76 8P77 8P78 8P79 8P7L 8PLZ 8PYR 8R99 8R9A 8R9B 8R9O 8R9S 8R9U 8S0R 8S0T	1IKT 1S9C 1ZBQ 6Z1W 6Z1X 8AF2 8AF3
Enriched GO Terms of Interacting Partners?		DNA-templated Transcription Nucleobase-containing Compound Biosynthetic Process Transcription By RNA Polymerase II Transcription Factor TFIIH Core Complex RNA Metabolic Process Transcription Factor TFIIH Holo Complex Nucleoplasm Nucleic Acid Metabolic Process Transcription Initiation At RNA Polymerase II Promoter Macromolecule Biosynthetic Process Transcription Factor TFIID Complex Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Initiation Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Nucleotide-excision Repair Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Primary Metabolic Process Regulation Of Mitotic Cell Cycle Intracellular Signal Transduction RNA Polymerase II General Transcription Initiation Factor Activity Regulation Of Cell Cycle Phase Transition Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Protein-containing Complex Regulation Of Cell Cycle DNA Repair DNA-templated Transcription Elongation DNA Damage Response Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of MiRNA Transcription Chromatin CAK-ERCC2 Complex Hormone-mediated Signaling Pathway Regulation Of MiRNA Metabolic Process Cellular Response To Stress Transcription Regulator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process	Regulation Of Norepinephrine Uptake Cellular Response To Stress Transporter Regulator Activity Positive Regulation Of Protein-containing Complex Assembly Intracellular Signal Transduction Fibroblast Apoptotic Process Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Response To Metal Ion Adherens Junction Assembly Protein-containing Complex DNA Damage Response Response To Stress Response To Oxidative Stress Response To Lipid Interleukin-6-mediated Signaling Pathway Regulation Of Protein-containing Complex Assembly Response To UV Fc-epsilon Receptor Signaling Pathway Response To Reactive Oxygen Species Regulation Of Cell Population Proliferation Multicellular Organismal-level Homeostasis Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Cellular Component Biogenesis Adherens Junction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cytosol Cellular Response To Oxidative Stress Positive Regulation Of Cellular Component Organization Kinesin Binding Tau Protein Binding Response To Dexamethasone Regulation Of Cell Activation Leukocyte Apoptotic Process Adherens Junction Organization Actin Cytoskeleton Homeostatic Process Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Response To Xenobiotic Stimulus Response To External Biotic Stimulus Mitochondrion Organization Animal Organ Regeneration Positive Regulation Of Calcium Ion Transmembrane Transport Caspase Complex RNA Polymerase II CTD Heptapeptide Repeat S5 Kinase Activity RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Macrophage Activation Fc Receptor Signaling Pathway
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