CDK7 and HSD17B4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CDK7	HSD17B4
Gene Name		cyclin-dependent kinase 7	hydroxysteroid (17-beta) dehydrogenase 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Holo TFIIH Complex Cytoplasm Mitochondrion Perinuclear Region Of Cytoplasm	Mitochondrion Peroxisome Peroxisomal Membrane Peroxisomal Matrix Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Coactivator Activity Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity RNA Polymerase II Carboxy-terminal Domain Kinase Activity Androgen Receptor Binding	3-hydroxyacyl-CoA Dehydrogenase Activity Receptor Binding Long-chain-enoyl-CoA Hydratase Activity Isomerase Activity 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA Hydratase Activity Protein Homodimerization Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Protein Phosphorylation Cell Cycle Arrest Cell Proliferation Gene Expression Viral Process Androgen Receptor Signaling Pathway Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Cell Division	Very Long-chain Fatty Acid Metabolic Process Osteoblast Differentiation Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Metabolic Process Bile Acid Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Unsaturated Fatty Acid Metabolic Process Alpha-linolenic Acid Metabolic Process Very Long-chain Fatty-acyl-CoA Metabolic Process Medium-chain Fatty-acyl-CoA Metabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process Sertoli Cell Development
Pathways		RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Tat-mediated elongation of the HIV-1 transcript Cyclin E associated events during G1/S transition Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in TC-NER NoRC negatively regulates rRNA expression G1/S Transition Mitotic G1-G1/S phases S Phase Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Global Genomic NER (GG-NER) RNA Polymerase II Transcription Initiation And Promoter Clearance Cyclin A:Cdk2-associated events at S phase entry Mitotic G2-G2/M phases Transcription of the HIV genome Nucleotide Excision Repair RNA Polymerase II Transcription RNA Polymerase I Transcription Initiation HIV Infection RNA Polymerase I Promoter Clearance Formation of the Early Elongation Complex G2/M Transition RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE Cyclin A/B1 associated events during G2/M transition RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Dual incision reaction in GG-NER RNA Polymerase I Transcription mRNA Capping RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination G1 Phase Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Cell Cycle, Mitotic Cyclin D associated events in G1 Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of incision complex in GG-NER RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation	Beta-oxidation of pristanoyl-CoA Bile acid and bile salt metabolism alpha-linolenic acid (ALA) metabolism Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Metabolism of lipids and lipoproteins alpha-linolenic (omega3) and linoleic (omega6) acid metabolism Synthesis of bile acids and bile salts Beta-oxidation of very long chain fatty acids Peroxisomal lipid metabolism
Drugs		Phosphonothreonine Flavopiridol	NADH Nicotinamide-Adenine-Dinucleotide 3r-Hydroxydecanoyl-Coa
Diseases
GWAS
Protein-Protein Interactions		47 interactors: APP AR BRCA1 CCNA2 CCNB1 CCNH CDC37 CDK1 CDK2 CDK6 CDK9 CTD CTDP1 CUX1 E2F1 ERCC2 ERCC3 ESR1 GTF2E1 GTF2E2 GTF2H1 GTF2H2 GTF2H3 GTF2H5 HIST1H1A HLA-DQA1 HSD17B4 LASP1 MBP MCM7 MNAT1 NEK6 PCGF6 POLR2A POLR2B PRKCI RARA SMAD1 SRPK1 SRPK2 SUPT5H TAF7 TCEA1 THRA TP53 UBE2D1 VDR	7 interactors: ACTB BAK1 CASP9 CDK7 MAPK8 NDRG1 SNCA
Entrez ID		1022	3295
HPRD ID		15993	03514
Ensembl ID		ENSG00000134058	ENSG00000133835
Uniprot IDs		P50613	B2R659 E7ET17 E7EWE5 G5E9S2 P51659
PDB IDs		1LG3 1PA8 1UA2 2HIC	1IKT 1S9C 1ZBQ
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Elongation Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Viral Process DNA-templated Transcription, Initiation Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Regulation Of Viral Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Viral Process Positive Regulation Of Cellular Biosynthetic Process 7-methylguanosine MRNA Capping Regulation Of Gene Expression Nucleotide-excision Repair 7-methylguanosine RNA Capping Regulation Of RNA Metabolic Process Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Response To DNA Damage Stimulus Transcription, DNA-templated Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process RNA Metabolic Process Regulation Of Cell Cycle Viral Process Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Transcription Elongation From RNA Polymerase I Promoter Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Metabolic Process Transcription From RNA Polymerase I Promoter Nucleotide-excision Repair, DNA Damage Removal Nitrogen Compound Metabolic Process DNA Repair Cellular Response To Stress Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Termination Of RNA Polymerase I Transcription	Response To Inorganic Substance Cellular Response To Stress Response To Metal Ion Response To Stress Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Immune System Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Positive Regulation Of Endopeptidase Activity Response To UV Positive Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Intrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Activation Regulation Of Cysteine-type Endopeptidase Activity Response To Other Organism Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Biotic Stimulus Positive Regulation Of Intracellular Transport Protein Processing Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Innate Immune Response Signaling Fc Receptor Signaling Pathway Response To External Stimulus Cellular Response To DNA Damage Stimulus Positive Regulation Of Calcium Ion Transport Into Cytosol Cell Communication Membrane Organization Positive Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Response To Lipopolysaccharide Aging Apoptotic Process Response To Molecule Of Bacterial Origin Response To Light Stimulus Programmed Cell Death Apoptotic Signaling Pathway Positive Regulation Of Hydrolase Activity Cell Death Regulation Of Protein Metabolic Process Death Positive Regulation Of Mitochondrion Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway
Tagcloud ?		arrested asynchronous biochemically carboxy cdc2 cip1 enter extracts inactivated machinery microtubule mitosis mitotic nocodazole p21waf1 p36 p62 polymerase polymerization prepared reconstituted repressed repression reproduced rescue sdi1 shutdown tfiid tfiih	aas aass abused anabolic androgenic arr19 cyp11a1 cyp17a1 dax1 disturbed enanthate gnrhr hsd3b1 hsd3b5 insl3 intramuscular leydig lhcgr milieu oppositely prka prlr1 prlr2 prolactin star steroidogenesis steroidogenic testosterone tspo
Tagcloud (Difference) ?		arrested asynchronous biochemically carboxy cdc2 cip1 enter extracts inactivated machinery microtubule mitosis mitotic nocodazole p21waf1 p36 p62 polymerase polymerization prepared reconstituted repressed repression reproduced rescue sdi1 shutdown tfiid tfiih	aas aass abused anabolic androgenic arr19 cyp11a1 cyp17a1 dax1 disturbed enanthate gnrhr hsd3b1 hsd3b5 insl3 intramuscular leydig lhcgr milieu oppositely prka prlr1 prlr2 prolactin star steroidogenesis steroidogenic testosterone tspo
Tagcloud (Intersection) ?