CDK7 and CCNA2

Number of citations of the paper that reports this interaction (PMID 16327805)
33

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		CDK7	CCNA2
Gene Name		cyclin-dependent kinase 7	cyclin A2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Holo TFIIH Complex Cytoplasm Mitochondrion Perinuclear Region Of Cytoplasm	Female Pronucleus Male Pronucleus Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Transcription Coactivator Activity Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity RNA Polymerase II Carboxy-terminal Domain Kinase Activity Androgen Receptor Binding	Protein Binding Protein Kinase Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Protein Phosphorylation Cell Cycle Arrest Cell Proliferation Gene Expression Viral Process Androgen Receptor Signaling Pathway Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Cell Division	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Mitotic Nuclear Division Mitotic G2 DNA Damage Checkpoint Ras Protein Signal Transduction Regulation Of G2/M Transition Of Mitotic Cell Cycle Organ Regeneration Response To Estradiol Response To Glucagon Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Fibroblast Proliferation Cell Division
Pathways		RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Tat-mediated elongation of the HIV-1 transcript Cyclin E associated events during G1/S transition Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in TC-NER NoRC negatively regulates rRNA expression G1/S Transition Mitotic G1-G1/S phases S Phase Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Global Genomic NER (GG-NER) RNA Polymerase II Transcription Initiation And Promoter Clearance Cyclin A:Cdk2-associated events at S phase entry Mitotic G2-G2/M phases Transcription of the HIV genome Nucleotide Excision Repair RNA Polymerase II Transcription RNA Polymerase I Transcription Initiation HIV Infection RNA Polymerase I Promoter Clearance Formation of the Early Elongation Complex G2/M Transition RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE Cyclin A/B1 associated events during G2/M transition RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Dual incision reaction in GG-NER RNA Polymerase I Transcription mRNA Capping RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination G1 Phase Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Cell Cycle, Mitotic Cyclin D associated events in G1 Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of incision complex in GG-NER RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation	Cellular Senescence G2/M Transition Orc1 removal from chromatin Cyclin E associated events during G1/S transition Cyclin A/B1 associated events during G2/M transition G1/S Transition G2 Phase Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases DNA Damage/Telomere Stress Induced Senescence Synthesis of DNA Regulation of DNA replication G0 and Early G1 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase S Phase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic Orc1 removal from chromatin SCF(Skp2)-mediated degradation of p27/p21 Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G2-G2/M phases
Drugs		Phosphonothreonine Flavopiridol
Diseases
GWAS
Protein-Protein Interactions		47 interactors: APP AR BRCA1 CCNA2 CCNB1 CCNH CDC37 CDK1 CDK2 CDK6 CDK9 CTD CTDP1 CUX1 E2F1 ERCC2 ERCC3 ESR1 GTF2E1 GTF2E2 GTF2H1 GTF2H2 GTF2H3 GTF2H5 HIST1H1A HLA-DQA1 HSD17B4 LASP1 MBP MCM7 MNAT1 NEK6 PCGF6 POLR2A POLR2B PRKCI RARA SMAD1 SRPK1 SRPK2 SUPT5H TAF7 TCEA1 THRA TP53 UBE2D1 VDR	50 interactors: ARID4A BRCA1 BRCA2 BTG1 CALM1 CDC20 CDC25C CDC27 CDC6 CDK1 CDK2 CDK3 CDK7 CDKN1A CDKN1B CDT1 CKS1B CKS1BP7 CKS2 DTNBP1 E2F1 E2F3 FEN1 FZR1 HERC5 HIRA HIST1H1A HIST1H1B ITGB3BP KAT2B MYBL2 NFYA PGR POLA1 PRC1 PSMD4 PTMA RAD23A RB1 RBL1 RBL2 RPA1 SKP1 SKP2 SP1 TAF1 TP53 TRAF3IP1 UBTF USP37
Entrez ID		1022	890
HPRD ID		15993	00453
Ensembl ID		ENSG00000134058	ENSG00000145386
Uniprot IDs		P50613	P20248
PDB IDs		1LG3 1PA8 1UA2 2HIC	1E9H 1FIN 1FVV 1GY3 1H1P 1H1Q 1H1R 1H1S 1H24 1H25 1H26 1H27 1H28 1JST 1JSU 1OGU 1OI9 1OIU 1OIY 1OKV 1OKW 1OL1 1OL2 1P5E 1PKD 1QMZ 1URC 1VYW 2BKZ 2BPM 2C4G 2C5N 2C5O 2C5V 2C5X 2C6T 2CCH 2CCI 2CJM 2I40 2IW6 2IW8 2IW9 2UUE 2UZB 2UZD 2UZE 2UZL 2V22 2WEV 2WFY 2WHB 2WIH 2WIP 2WMA 2WMB 2WPA 2WXV 2X1N 3EID 3EJ1 3EOC 3F5X 4BCK 4BCM 4BCN 4BCP 4EOI 4EOJ 4EOK 4EOL 4EOM 4EON 4EOO 4EOP 4EOQ 4EOR 4EOS 4FX3
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Elongation Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Viral Process DNA-templated Transcription, Initiation Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Regulation Of Viral Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Viral Process Positive Regulation Of Cellular Biosynthetic Process 7-methylguanosine MRNA Capping Regulation Of Gene Expression Nucleotide-excision Repair 7-methylguanosine RNA Capping Regulation Of RNA Metabolic Process Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Response To DNA Damage Stimulus Transcription, DNA-templated Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process RNA Metabolic Process Regulation Of Cell Cycle Viral Process Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Transcription Elongation From RNA Polymerase I Promoter Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Metabolic Process Transcription From RNA Polymerase I Promoter Nucleotide-excision Repair, DNA Damage Removal Nitrogen Compound Metabolic Process DNA Repair Cellular Response To Stress Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Termination Of RNA Polymerase I Transcription	Cell Cycle Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Regulation Of Cell Cycle G1/S Transition Of Mitotic Cell Cycle Organelle Organization Cell Cycle Checkpoint Cell Division Regulation Of Cell Cycle Process Positive Regulation Of Cellular Metabolic Process Chromosome Organization Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Chromatin Organization Regulation Of Protein Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Mitotic Nuclear Division Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Regulation Of Protein Catabolic Process Macromolecule Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Regulation Of Cell Proliferation Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Positive Regulation Of Gene Expression Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Cell Cycle Signal Transduction By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Proteasomal Protein Catabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Chromatin Modification DNA Replication Positive Regulation Of Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of G1/S Transition Of Mitotic Cell Cycle Heterocycle Metabolic Process
Tagcloud ?		arrested asynchronous biochemically carboxy cdc2 cip1 enter extracts inactivated machinery microtubule mitosis mitotic nocodazole p21waf1 p36 p62 polymerase polymerization prepared reconstituted repressed repression reproduced rescue sdi1 shutdown tfiid tfiih	calm3 cblb ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Difference) ?		arrested asynchronous biochemically carboxy cdc2 cip1 enter extracts inactivated machinery microtubule mitosis mitotic nocodazole p21waf1 p36 p62 polymerase polymerization prepared reconstituted repressed repression reproduced rescue sdi1 shutdown tfiid tfiih	calm3 cblb ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Intersection) ?