STX6 and STX4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		STX6	STX4
Gene Name		syntaxin 6	syntaxin 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Early Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Integral Component Of Membrane Clathrin-coated Vesicle SNARE Complex Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm	Extracellular Space Intracellular Endosome Vacuole Trans-Golgi Network Cytosol Plasma Membrane Synaptic Vesicle Cell Surface Membrane Integral Component Of Membrane Basolateral Plasma Membrane Lamellipodium SNARE Complex Myelin Sheath Adaxonal Region Somatodendritic Compartment Specific Granule Dendritic Spine Lateral Loop Synapse Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	SNAP Receptor Activity Protein Binding Syntaxin Binding	SNARE Binding SNAP Receptor Activity Protein Binding Sphingomyelin Phosphodiesterase Activator Activity
	Biological Process	Intracellular Protein Transport Vesicle Fusion Endosome Organization Regulation Of Protein Localization Retrograde Transport, Endosome To Golgi Golgi Vesicle Transport Golgi Ribbon Formation	Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Blood Coagulation Positive Regulation Of Cell Proliferation Regulation Of Exocytosis Platelet Activation Positive Regulation Of Cell Migration Synaptic Vesicle Fusion To Presynaptic Membrane Response To Hydroperoxide SNARE Complex Assembly Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Catalytic Activity Positive Regulation Of Eosinophil Degranulation Positive Regulation Of Cell Adhesion Vesicle Docking Organelle Fusion Positive Regulation Of Chemotaxis Positive Regulation Of Immunoglobulin Secretion Long-term Synaptic Potentiation Membrane Organization Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Surface
Pathways			Response to elevated platelet cytosolic Ca2+ Translocation of GLUT4 to the plasma membrane Disinhibition of SNARE formation Platelet activation, signaling and aggregation trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS		Progressive supranuclear palsy ( 21685912)
Protein-Protein Interactions		15 interactors: EEA1 GOPC GOSR2 MARCH2 NAPB PSMA3 PTPN9 SNAP23 SNAP29 STX16 STX4 STX7 VAMP4 VPS11 VPS18	48 interactors: ACTB BET1 CYBRD1 DLG1 GIMAP5 GOSR2 ITSN2 LLGL1 NAPA NAPB NSF PSMA3 RAB11A RAB4A RAB5A SCRIB SEC22A SEPT5 SNAP23 SNAP25 SNAP29 SNAP47 STX12 STX16 STX3 STX5 STX6 STX7 STX8 STXBP3 STXBP4 STXBP5 STXBP6 SYT1 SYT4 SYT7 TXLNA TXLNB TXLNG VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VAMP7 VAMP8 VAPB VTI1B
Entrez ID		10228	6810
HPRD ID		07231	01722
Ensembl ID		ENSG00000135823	ENSG00000103496
Uniprot IDs		B4DR17 O43752	A8MXY0 B7Z425 Q12846
PDB IDs		2NPS
Enriched GO Terms of Interacting Partners?		Vesicle Fusion Membrane Fusion Organelle Fusion Vesicle-mediated Transport Vesicle Organization Establishment Of Localization In Cell Membrane Organization Cellular Localization Protein Transport Establishment Of Protein Localization Intracellular Transport Protein Localization Regulation Of Protein Localization To Plasma Membrane Synaptic Vesicle Fusion To Presynaptic Membrane Transport Vesicle Docking Post-Golgi Vesicle-mediated Transport Membrane Docking Golgi Vesicle Transport Cellular Protein Localization Synaptic Vesicle Transport Intracellular Protein Transport Exocytosis Regulation Of Establishment Of Protein Localization To Plasma Membrane Organelle Organization Organelle Localization Synaptic Vesicle Exocytosis Establishment Of Vesicle Localization Golgi Ribbon Formation Vesicle Localization Secretion By Cell Regulation Of Golgi To Plasma Membrane Protein Transport Synaptic Vesicle Priming SNARE Complex Assembly Secretion Neurotransmitter Secretion Establishment Of Organelle Localization Cellular Protein Complex Assembly Regulation Of Vesicle-mediated Transport Regulation Of Neurotransmitter Levels Neurotransmitter Transport Endosomal Transport Protein Complex Assembly Vesicle Targeting Synaptic Transmission Intra-Golgi Vesicle-mediated Transport Cellular Macromolecular Complex Assembly Cellular Component Assembly Synaptic Vesicle To Endosome Fusion Cytoplasmic Sequestering Of CFTR Protein	Vesicle Fusion Membrane Fusion Organelle Fusion Vesicle-mediated Transport Membrane Organization Vesicle Organization Establishment Of Localization In Cell Cellular Localization Exocytosis Secretion By Cell Secretion Transport Golgi Vesicle Transport Protein Transport Establishment Of Protein Localization Protein Localization Intracellular Transport Neurotransmitter Secretion Regulation Of Exocytosis Regulation Of Cellular Localization Vesicle Docking Regulation Of Vesicle-mediated Transport Post-Golgi Vesicle-mediated Transport Membrane Docking Regulation Of Neurotransmitter Levels Intracellular Protein Transport Neurotransmitter Transport Synaptic Vesicle Exocytosis Vesicle Fusion With Golgi Apparatus Synaptic Vesicle Transport Cellular Protein Localization Regulation Of Secretion Establishment Of Vesicle Localization Vesicle Localization Cell-cell Signaling Organelle Organization Endomembrane System Organization Cytoplasmic Transport SNARE Complex Assembly Endosomal Transport Regulation Of Protein Localization To Plasma Membrane Synaptic Vesicle Fusion To Presynaptic Membrane Organelle Localization Establishment Of Organelle Localization Synaptic Transmission Golgi To Plasma Membrane Transport Regulation Of Protein Localization ER To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Protein Transport Positive Regulation Of Exocytosis
Tagcloud ?		alpha5beta1 alphavbeta3 boundaries c1 cho cholesterol endosome endosomes export hamster imbalance integrins interferes niemann npc1 ovary pick rab11 re recycling res restoration restores snare syntaxin tgn transferrin tuning vamp3	address ageing armx3 b2mg consequence dep1 ebp50 effectors fact issue lancl1 maintaining modulators note ntal organismal pld3 preferentially recognize screened senescence senescent sorting straightforward triggering utilized vamp3 view vps26a
Tagcloud (Difference) ?		alpha5beta1 alphavbeta3 boundaries c1 cho cholesterol endosome endosomes export hamster imbalance integrins interferes niemann npc1 ovary pick rab11 re recycling res restoration restores snare syntaxin tgn transferrin tuning	address ageing armx3 b2mg consequence dep1 ebp50 effectors fact issue lancl1 maintaining modulators note ntal organismal pld3 preferentially recognize screened senescence senescent sorting straightforward triggering utilized view vps26a
Tagcloud (Intersection) ?		vamp3