TRIB1 and MAP2K4

Number of citations of the paper that reports this interaction (PMID 15299019)
60

Data Source:
HPRD (in vivo)

		TRIB1	MAP2K4
Gene Name		tribbles pseudokinase 1	mitogen-activated protein kinase kinase 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Intracellular Nucleus Cytosol Axon Dendrite Cytoplasm Perikaryon
	Molecular Function	Protein Kinase Activity Protein Kinase Inhibitor Activity ATP Binding Transcription Factor Binding Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Regulator Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding
	Biological Process	Protein Phosphorylation Negative Regulation Of Protein Kinase Activity JNK Cascade Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Lipopolysaccharide Regulation Of MAP Kinase Activity Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Smooth Muscle Cell Proliferation	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Signal Transduction JNK Cascade Activation Of JUN Kinase Activity Pathogenesis Peptidyl-tyrosine Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Innate Immune Response Positive Regulation Of DNA Replication Stress-activated MAPK Cascade Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Mechanical Stimulus Cellular Response To Sorbitol
Pathways			Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence FCERI mediated MAPK activation Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Uptake and actions of bacterial toxins MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Uptake and function of anthrax toxins Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Oxidative Stress Induced Senescence Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling
Drugs
Diseases
GWAS		Adiponectin levels ( 22479202) Cholesterol, total ( 19060911 20686565) HDL cholesterol ( 20686565) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) Inflammatory bowel disease ( 23128233) LDL cholesterol ( 20864672 19060911 20686565) Lipid metabolism phenotypes ( 19936222) Liver enzyme levels (alanine transaminase) ( 22001757) Liver enzyme levels (alkaline phosphatase) ( 22001757) Obesity-related traits ( 23251661) Response to statin therapy ( 20339536) Triglycerides ( 18193043 18193044 20864672 19060906 20139978 20686565) Triglycerides-Blood Pressure (TG-BP) ( 21386085)	Response to amphetamines ( 22952603)
Protein-Protein Interactions		4 interactors: ALOX12 MAP2K1 MAP2K4 MAP2K7	37 interactors: AKT1 APP ARRB1 ARRB2 CFLAR DUSP22 EFNA4 FLNA FLNC GEMIN5 ITCH JUN LRRK2 MAP2K6 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K14 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K7 MAP3K8 MAP4K2 MAPK1 MAPK10 MAPK12 MAPK14 MAPK8 MAPK8IP3 MAPK9 RBBP8 SPAG9 TRIB1 ZAK
Entrez ID		10221	6416
HPRD ID		09863	03213
Ensembl ID		ENSG00000173334	ENSG00000065559
Uniprot IDs		Q96RU8	B7ZA62 P45985
PDB IDs			3ALN 3ALO 3VUT
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Sorbitol Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of MAPK Activity Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Stress-activated MAPK Cascade Pathogenesis Positive Regulation Of MAP Kinase Activity Fc-epsilon Receptor Signaling Pathway MAPK Cascade Regulation Of Innate Immune Response Positive Regulation Of Cellular Protein Metabolic Process Fc Receptor Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of MAP Kinase Activity Positive Regulation Of Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Activation Of JUN Kinase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Neuron Apoptotic Process Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Death Positive Regulation Of Apoptotic Process Cellular Response To Carbohydrate Stimulus Positive Regulation Of Programmed Cell Death	MAPK Cascade Signal Transduction By Phosphorylation Regulation Of MAPK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of MAPK Cascade Activation Of MAPK Activity Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Activation Of Protein Kinase Activity Regulation Of MAP Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process JNK Cascade Positive Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Activation Of MAPKK Activity Positive Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Kinase Activity Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Modification Process Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Regulation Of Signal Transduction Phosphorylation Regulation Of Signaling Regulation Of JNK Cascade Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Intracellular Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Phosphate-containing Compound Metabolic Process Positive Regulation Of JUN Kinase Activity Cell Death Death Positive Regulation Of JNK Cascade Regulation Of JUN Kinase Activity
Tagcloud ?		05x10 36x10 amd americans arms2 assuming cetp cfh corrections european fundus generalize genomics kctd10 lpl mexican mvk photography powered rs10490924 rs1061170 rs1800775 rs2338104 rs328 rs6987702 singaporeans strict survive uncorrected	aurka aurkb bioinformatics cdkn2a copy custom describing epha5 flt4 frameshift insertions interrogating kdm6a leiomyosarcomas locally losses multiplexed nf1 ngs notch1 pdgfrb pik3ca pipeline rationale rb1 sarcomas soft stratification targetable
Tagcloud (Difference) ?		05x10 36x10 amd americans arms2 assuming cetp cfh corrections european fundus generalize genomics kctd10 lpl mexican mvk photography powered rs10490924 rs1061170 rs1800775 rs2338104 rs328 rs6987702 singaporeans strict survive uncorrected	aurka aurkb bioinformatics cdkn2a copy custom describing epha5 flt4 frameshift insertions interrogating kdm6a leiomyosarcomas locally losses multiplexed nf1 ngs notch1 pdgfrb pik3ca pipeline rationale rb1 sarcomas soft stratification targetable
Tagcloud (Intersection) ?