TRIB1 and ALOX12

Number of citations: 0 (PubMedID 10727209)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		TRIB1	ALOX12
Name		tribbles pseudokinase 1	arachidonate 12-lipoxygenase, 12S type
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Cytosol Membrane Sarcolemma Extracellular Exosome
	Molecular Function	Protein Kinase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Enzyme Binding Protein Kinase Binding Enzyme Regulator Activity Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Regulator Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity	Arachidonate 12(S)-lipoxygenase Activity Iron Ion Binding Protein Binding Linoleate 13S-lipoxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Hydrolase Activity Metal Ion Binding Hepoxilin-epoxide Hydrolase Activity Arachidonate 15-lipoxygenase Activity Dioxygenase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Protein Modification Process Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Lipopolysaccharide Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Positive Regulation Of Eosinophil Differentiation Positive Regulation Of Macrophage Differentiation Negative Regulation Of Neutrophil Differentiation Negative Regulation Of JNK Cascade Negative Regulation Of Smooth Muscle Cell Proliferation	Lipid Metabolic Process Fatty Acid Metabolic Process Negative Regulation Of Muscle Cell Apoptotic Process Arachidonate Metabolic Process Lipoxygenase Pathway Fatty Acid Oxidation Unsaturated Fatty Acid Metabolic Process Lipid Oxidation Superoxide Anion Generation Long-chain Fatty Acid Biosynthetic Process Linoleic Acid Metabolic Process Hepoxilin Biosynthetic Process Establishment Of Skin Barrier Negative Regulation Of Platelet Aggregation Leukotriene A4 Metabolic Process Lipoxin A4 Biosynthetic Process Lipoxin B4 Biosynthetic Process
Pathways		NGF-stimulated transcription	Synthesis of Hepoxilins (HX) and Trioxilins (TrX) Biosynthesis of Lipoxins (LX) Synthesis of 12-eicosatetraenoic acid derivatives Biosynthesis of DHA-derived SPMs Biosynthesis of DPAn-6 SPMs Biosynthesis of DPAn-3-derived maresins
GWAS		A body shape index ( 34021172 ) Abdominal aortic aneurysm ( 32981348 ) Adiponectin levels ( 22479202 ) Adult body size ( 32376654 ) Alanine aminotransferase levels ( 33339817 33547301 34315874 ) Alanine transaminase levels ( 29403010 ) Apolipoprotein A1 levels ( 32203549 ) Apolipoprotein B levels ( 32203549 ) Aspartate aminotransferase levels ( 33547301 34315874 ) Birth weight ( 27680694 31043758 ) C-reactive protein levels ( 30388399 ) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809 ) Carotid intima media thickness x smoking interaction ( 32117412 ) Cholesterol ( 31902109 ) Cholesterol, total ( 19060911 20686565 24097068 25961943 26582766 ) Coronary artery disease ( 26343387 32469254 33020668 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Diastolic blood pressure ( 27841878 ) Estimated glomerular filtration rate ( 30604766 31015462 31152163 ) Fractures (paediatric) ( 32742401 ) Gamma glutamyl transferase levels ( 29403010 33339817 ) Glycated hemoglobin levels ( 34059833 ) Glycine levels ( 30837465 31070104 ) HDL cholesterol ( 20686565 24097068 25961943 ) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085 ) HDL cholesterol levels ( 28334899 30698716 32203549 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) High density lipoprotein cholesterol levels ( 33339817 ) Hypertriglyceridemia ( 27599772 ) Inflammatory bowel disease ( 23128233 ) Iron status biomarkers (ferritin levels) ( 33536631 ) LDL cholesterol ( 19060911 20686565 20864672 24097068 25961943 ) LDL cholesterol levels ( 28334899 30698716 32203549 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Lipid metabolism phenotypes ( 19936222 ) Lipid traits ( 24386095 ) Liver enzyme levels (alanine transaminase) ( 22001757 33972514 ) Liver enzyme levels (alkaline phosphatase) ( 22001757 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Low density lipoprotein cholesterol levels ( 29403010 33339817 ) Metabolic syndrome ( 31589552 ) Metabolite levels ( 23823483 ) Microalbuminuria ( 31511532 ) Mosquito bite size ( 28199695 ) Myocardial infarction ( 26343387 33532862 ) Nonalcoholic fatty liver disease ( 31311600 34841290 ) Obesity-related traits ( 23251661 ) Percent liver fat ( 34128465 ) Response to statin therapy ( 20339536 ) Rosacea symptom severity ( 29771307 ) Serum alkaline phosphatase levels ( 29403010 33339817 33547301 ) Serum metabolite levels ( 31636271 ) Serum metabolite levels (CMS) ( 31636271 ) Serum total protein levels ( 29403010 ) Systolic blood pressure ( 27841878 ) Total cholesterol levels ( 28334899 29403010 33339817 ) Triglyceride levels ( 28334899 29403010 30698716 30911093 31647587 32203549 33339817 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels in HIV infection ( 33109212 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglycerides ( 18193043 18193044 19060906 20139978 20686565 20864672 24097068 24886709 25961943 26582766 26780889 ) Triglycerides-Blood Pressure (TG-BP) ( 21386085 ) Type 2 diabetes ( 32499647 ) Urinary albumin excretion ( 30220432 ) Urinary albumin excretion (no hypertensive medication) ( 30220432 ) Urinary albumin-to-creatinine ratio ( 30910378 31511532 31630189 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625 ) White blood cell count (basophil) ( 29403010 )	Mean platelet volume ( 32888494 )
Interacting Genes		10 interacting genes: ACACA ALOX12 CEBPB CEBPD CEBPE FBXW8 KLC2 MAP2K1 MAP2K4 MAP2K7	7 interacting genes: ITGB4 KAT5 KRT5 KRT85 LMNA PLA2G2A TRIB1
Entrez ID		10221	239
HPRD ID		09863	01066
Ensembl ID		ENSG00000173334	ENSG00000108839
Uniprot IDs		Q96RU8	P18054
PDB IDs		5CEK 5CEM 5IGO 5IGQ 6DC0	3D3L 8GHB 8GHC 8GHD 8GHE
GO Terms Enriched among Interactors		MAP Kinase Kinase Activity JUN Kinase Kinase Activity Integrated Stress Response Signaling Intracellular Signaling Cassette Cellular Senescence Negative Regulation Of Homotypic Cell-cell Adhesion Regulation Of Motor Neuron Apoptotic Process Response To Lipid RNA Polymerase II Transcription Regulator Complex Protein Tyrosine Kinase Activity Fc-epsilon Receptor Signaling Pathway Cellular Response To Lipid Cellular Response To Lipopolysaccharide Placenta Blood Vessel Development Cellular Response To Molecule Of Bacterial Origin Negative Regulation Of Cell-cell Adhesion Intracellular Signal Transduction Response To Wounding MAPK Cascade Regulation Of Neuron Apoptotic Process Cellular Response To Interleukin-1 Fatty Acid Derivative Biosynthetic Process Fc Receptor Signaling Pathway Hepoxilin-epoxide Hydrolase Activity Lipoxin B4 Biosynthetic Process JNK Cascade Kinesin I Complex Negative Regulation Of Cell Adhesion Response To Lipopolysaccharide Malonyl-CoA Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Fatty Acid Derivative Metabolic Process Cellular Response To Oxygen-containing Compound Acetyl-CoA Carboxylase Activity Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Leukotriene A4 Metabolic Process Lipoxin B4 Metabolic Process Linoleate 13S-lipoxygenase Activity Arachidonate 15-lipoxygenase Activity Lipoxin A4 Biosynthetic Process Negative Regulation Of Apoptotic Process Response To Molecule Of Bacterial Origin Response To Interleukin-1 Positive Regulation Of Osteoblast Differentiation Cellular Response To Stress Positive Regulation Of Cell Differentiation Granuloma Formation C/EBP Complex Protein Serine Kinase Activity	Intermediate Filament Phosphatidylethanolamine Metabolic Process Peripheral Nervous System Myelin Formation Structural Constituent Of Cytoskeleton Intermediate Filament Polymerization Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament Polymerization Or Depolymerization Keratinization Keratin Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Organization DNA Double-strand Break Attachment To Nuclear Envelope Nuclear Lumen Site Of Double-strand Break Negative Regulation Of Multicellular Organismal Process Structural Constituent Of Nuclear Lamina Cellular Senescence Phosphatidylcholine Metabolic Process Positive Regulation Of Eosinophil Differentiation Negative Regulation Of Neutrophil Differentiation Histone H2AK5 Acetyltransferase Activity Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Histone H2A Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Epidermis Development Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Piccolo Histone Acetyltransferase Complex Hemidesmosome Assembly Nail Development Neuregulin Binding Tissue Development Structural Molecule Activity Negative Regulation Of Cell Population Proliferation Lamin Filament Perinuclear Region Of Cytoplasm Nuclear Pore Localization Intestinal Stem Cell Homeostasis Ubiquitin-protein Transferase Regulator Activity Positive Regulation Of Protein Acetylation Positive Regulation Of Aggrephagy Positive Regulation Of Leukocyte Differentiation Trophoblast Cell Migration Lipid Droplet Disassembly Hemidesmosome Negative Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Granulocyte Differentiation