HABP4 and PRKCQ

Number of citations of the paper that reports this interaction (PubMedID 14699138)
0

Data Source:
HPRD (in vivo, in vitro)

		HABP4	PRKCQ
Description		hyaluronan binding protein 4	protein kinase C theta
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleolus Cytoplasm Cytosol Cytoplasmic Stress Granule Cajal Body Sarcoplasm Nuclear Body Nuclear Speck Sarcomere Nuclear Membrane Gemini Of Cajal Bodies	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Membrane Aggresome Centriolar Satellite
	Molecular Function	RNA Binding Protein Binding SUMO Binding Ribosome Binding Translation Elongation Factor Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	MRNA Processing Regulation Of Translation RNA Splicing PML Body Organization Positive Regulation Of RNA Splicing Positive Regulation Of Translational Initiation Cellular Response To Mechanical Stimulus Ribosome Hibernation	Regulation Of Cell Growth Immune System Process Regulation Of DNA-templated Transcription Membrane Protein Ectodomain Proteolysis Inflammatory Response Axon Guidance Positive Regulation Of Telomere Maintenance Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Intracellular Signal Transduction CD4-positive, Alpha-beta T Cell Proliferation Fc-epsilon Receptor Signaling Pathway T Cell Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of DNA Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Chemotaxis Negative Regulation Of T Cell Apoptotic Process Regulation Of Platelet Aggregation Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of T-helper 2 Cell Activation
Pathways		Platelet degranulation	Apoptotic cleavage of cellular proteins Effects of PIP2 hydrolysis Downstream TCR signaling Inactivation, recovery and regulation of the phototransduction cascade FCERI mediated NF-kB activation FCERI mediated NF-kB activation Netrin-1 signaling G alpha (z) signalling events RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RAS processing
Drugs		Hyaluronic acid	Tamoxifen Staurosporine Staurosporine Phosphonothreonine Dequalinium Dexfosfoserine Benzoyl peroxide Fostamatinib
Diseases			Type I diabetes mellitus
GWAS		Appendicular lean mass ( 33097823) Height ( 25282103 31562340) Hip circumference adjusted for BMI ( 34021172) Household income (MTAG) ( 31844048) Waist circumference adjusted for body mass index ( 34021172)	Asthma ( 31959851 30929738) Asthma (bronchodilator response) ( 23508266) Asthma (childhood onset) ( 31036433 30929738) Autoimmune traits (pleiotropy) ( 30572963) Body mass index in asthmatics ( 23517042) Celiac disease ( 22057235 24999842) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic pain ( 33685280) Crohn's disease ( 28067908) Factor VII activity ( 30642921) Immune response to smallpox vaccine (IL-6) ( 22542470) Medication use (thyroid preparations) ( 31015401) Rheumatoid arthritis ( 30423114 24390342 18794853) Rheumatoid arthritis (ACPA-positive) ( 24532676) Type 1 diabetes ( 19430480 18978792)
Interacting Genes		27 interacting genes: C1QBP CHD3 CRK CRYAA DAXX ENO2 FRA10AC1 HMGXB4 KAT5 OGT PIAS3 PPP1R15A PRKCA PRKCB PRKCD PRKCG PRKCQ PRKCZ PRMT1 RACK1 SRSF9 SYNCRIP TOPORS TP53 UBE2I VIM YBX1	27 interacting genes: AKT1 BTK CARD11 CASP3 CBL CHUK CISH FYN GLRX3 GRM5 HABP4 ICAM3 IKBKB IKBKG IRS1 LCK LYN MARK3 MSN RASGRP3 SELL STK39 TAL1 VAV1 WIPF1 YWHAG YWHAQ
Entrez ID		22927	5588
HPRD ID		13628	02710
Ensembl ID		ENSG00000130956	ENSG00000065675
Uniprot IDs		Q5JVS0	Q04759
PDB IDs			1XJD 2ENJ 2ENN 2ENZ 2JED 4Q9Z 4RA5 5F9E
Enriched GO Terms of Interacting Partners?		Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Enzyme Binding Regulation Of Metabolic Process Post-transcriptional Regulation Of Gene Expression Protein Kinase C Signaling Positive Regulation Of Biosynthetic Process Nucleus Apoptotic Process Programmed Cell Death Cell Death Regulation Of Programmed Cell Death Intracellular Signal Transduction Regulation Of Insulin Receptor Signaling Pathway Presynaptic Cytosol Regulation Of Protein Metabolic Process Positive Regulation Of Translation Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Translation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Translation Cellular Response To Oxygen-containing Compound Negative Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Regulation Of MRNA Metabolic Process PML Body Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cytosol Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Signal Transduction Histone H3T6 Kinase Activity Positive Regulation Of Protein Metabolic Process Cytoplasm	Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Costimulation Immune Response-activating Signaling Pathway Positive Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Signal Transduction Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Immune System Process Positive Regulation Of Lymphocyte Activation Immune System Process Antigen Receptor-mediated Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Activation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion T Cell Receptor Signaling Pathway Signal Transduction Regulation Of Cell Activation Membrane Raft Intracellular Signaling Cassette Positive Regulation Of Cell-cell Adhesion Protein Phosphorylation Regulation Of Signal Transduction Fc-epsilon Receptor Signaling Pathway Protein Kinase Activity Regulation Of Cell-cell Adhesion Leukocyte Migration Leukocyte Proliferation Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Phosphorylation IkappaB Kinase Complex Leukocyte Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Fc-gamma Receptor Signaling Pathway Homeostatic Process Response To Xenobiotic Stimulus Cytosol
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