HABP4 and PPP1R15A

Number of citations of the paper that reports this interaction (PubMedID 16455055)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HABP4	PPP1R15A
Description		hyaluronan binding protein 4	protein phosphatase 1 regulatory subunit 15A
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleolus Cytoplasm Cytosol Cytoplasmic Stress Granule Cajal Body Sarcoplasm Nuclear Body Nuclear Speck Sarcomere Nuclear Membrane Gemini Of Cajal Bodies	Protein Phosphatase Type 1 Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane
	Molecular Function	RNA Binding Protein Binding SUMO Binding Ribosome Binding Translation Elongation Factor Binding	Protein Binding Protein Phosphatase 1 Binding Protein Phosphatase Regulator Activity Protein Kinase Binding Eukaryotic Initiation Factor EIF2 Binding Protein Phosphatase Activator Activity
	Biological Process	MRNA Processing Regulation Of Translation RNA Splicing PML Body Organization Positive Regulation Of RNA Splicing Positive Regulation Of Translational Initiation Cellular Response To Mechanical Stimulus Ribosome Hibernation	Regulation Of Translation Regulation Of Translational Initiation Apoptotic Process DNA Damage Response Positive Regulation Of Translational Initiation In Response To Stress Response To Endoplasmic Reticulum Stress Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Translational Initiation In Response To Stress Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein Localization To Endoplasmic Reticulum Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of PERK-mediated Unfolded Protein Response
Pathways		Platelet degranulation	Downregulation of TGF-beta receptor signaling Response of EIF2AK1 (HRI) to heme deficiency
Drugs		Hyaluronic acid
Diseases
GWAS		Appendicular lean mass ( 33097823) Height ( 25282103 31562340) Hip circumference adjusted for BMI ( 34021172) Household income (MTAG) ( 31844048) Waist circumference adjusted for body mass index ( 34021172)	High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		27 interacting genes: C1QBP CHD3 CRK CRYAA DAXX ENO2 FRA10AC1 HMGXB4 KAT5 OGT PIAS3 PPP1R15A PRKCA PRKCB PRKCD PRKCG PRKCQ PRKCZ PRMT1 RACK1 SRSF9 SYNCRIP TOPORS TP53 UBE2I VIM YBX1	16 interacting genes: BAG1 BCAR1 CTBP2 EIF2S1 HABP4 HSPA1A KIF3A KMT2A LYN POU3F3 PPP1CA PPP1R1A RAD21 SMARCB1 TSN ZNF512B
Entrez ID		22927	23645
HPRD ID		13628	06572
Ensembl ID		ENSG00000130956	ENSG00000087074
Uniprot IDs		Q5JVS0	O75807
PDB IDs			4XPN 7NXV 7NZM 8QZZ
Enriched GO Terms of Interacting Partners?		Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Enzyme Binding Regulation Of Metabolic Process Post-transcriptional Regulation Of Gene Expression Protein Kinase C Signaling Positive Regulation Of Biosynthetic Process Nucleus Apoptotic Process Programmed Cell Death Cell Death Regulation Of Programmed Cell Death Intracellular Signal Transduction Regulation Of Insulin Receptor Signaling Pathway Presynaptic Cytosol Regulation Of Protein Metabolic Process Positive Regulation Of Translation Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Translation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Translation Cellular Response To Oxygen-containing Compound Negative Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Regulation Of MRNA Metabolic Process PML Body Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cytosol Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Signal Transduction Histone H3T6 Kinase Activity Positive Regulation Of Protein Metabolic Process Cytoplasm	Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Translational Initiation In Response To Stress Cellular Response To Heat Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Response To Heat Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Translational Initiation Viral Genome Replication Regulation Of Translation In Response To Stress Protein-containing Complex Binding Response To Temperature Stimulus Nucleus Negative Regulation Of Cell Population Proliferation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Translation Initiation Ternary Complex Regulation Of Erythrocyte Differentiation Positive Regulation Of RNA Splicing Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Metanephric DCT Cell Differentiation Cell Division Metanephric Macula Densa Development Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Transcription Initiation-coupled Chromatin Remodeling B Cell Receptor Signaling Pathway Positive Regulation Of Gene Expression, Epigenetic Regulation Of Metabolic Process Protein Stabilization Positive Regulation Of Apoptotic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Programmed Cell Death Glycogen Metabolic Process Positive Regulation Of Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Protein Metabolic Process Denatured Protein Binding Positive Regulation Of Oligodendrocyte Progenitor Proliferation Circadian Regulation Of Gene Expression Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Protein-cysteine Methyltransferase Activity Metanephric Thick Ascending Limb Development
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