N4BP1 and LITAF

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		N4BP1	LITAF
Name		NEDD4 binding protein 1	lipopolysaccharide induced TNF factor
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol PML Body	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Endosome Golgi Apparatus Plasma Membrane Cytoplasmic Side Of Plasma Membrane Endosome Membrane Membrane Early Endosome Membrane Late Endosome Membrane Cytoplasmic Side Of Early Endosome Membrane Cytoplasmic Side Of Late Endosome Membrane Cytoplasmic Side Of Lysosomal Membrane
	Molecular Function	RNA Binding MRNA Binding Nuclease Activity RNA Nuclease Activity Protein Binding Hydrolase Activity Ubiquitin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding WW Domain Binding
	Biological Process	Negative Regulation Of Cytokine Production Immune System Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To UV Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of Innate Immune Response	Regulation Of Cytokine Production Regulation Of Macrophage Cytokine Production Response To Lipopolysaccharide Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Regulation of NF-kappa B signaling	None
Diseases		None	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Neutrophil percentage of granulocytes ( 27863252 ) Serum metabolite levels ( 33031748 ) Social autistic-like traits ( 24133439 ) Sum eosinophil basophil counts ( 27863252 )	Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Colorectal or endometrial cancer ( 26621817 ) Crohn's disease ( 28067908 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits (multivariate) ( 32602732 ) Gallstone disease ( 30504769 ) Heel bone mineral density ( 30598549 ) Hip index ( 34021172 ) Inflammatory bowel disease ( 23128233 28067908 ) LDL cholesterol levels ( 32203549 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Low density lipoprotein cholesterol levels ( 33339817 32154731 ) Monocyte percentage of white cells ( 32888494 ) QT interval ( 19305409 30679814 29874175 29213071 24952745 23166209 19305408 ) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482 ) TPE interval (resting) ( 32386560 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		8 interacting genes: AZI2 CDK6 ITCH LITAF LSM1 MID1 NEDD8 UBC	42 interacting genes: ARID5A ATXN1 BAG3 CALCOCO2 COMT CREB5 DAZAP2 EPN1 EPN2 EPN3 GGA3 HGS HIP1 HPCAL1 HPCAL4 ITCH KCNIP1 KCNIP4 N4BP1 NCALD NEDD4 OPTN POGZ RADIL RASSF3 REEP6 RNF208 RPS27A SMAD2 STAM2 STAT6 TAX1BP1 TNIP1 TNIP3 TOM1 UBA52 UBQLN1 UBQLN2 VENTX VSNL1 WWOX ZIC1
Entrez ID		9683	9516
HPRD ID		Not available	10354
Ensembl ID		ENSG00000102921	ENSG00000189067
Uniprot IDs		O75113	Q99732
PDB IDs		6Q3V	Not available
GO Terms Enriched among Interactors		Regulation Of Hematopoietic Stem Cell Differentiation Protein Tag Activity Regulation Of Hematopoietic Progenitor Cell Differentiation T Cell Activation Ubiquitin Protein Ligase Binding Endosome Membrane Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Stem Cell Differentiation Response To Virus Cytoplasm Cyclin D3-CDK6 Complex Lymphocyte Activation Cyclin D1-CDK6 Complex Cyclin D2-CDK6 Complex FBXO Family Protein Binding Macromolecule Catabolic Process Cytoplasmic Side Of Late Endosome Membrane Negative Regulation Of Canonical NF-kappaB Signal Transduction Gliogenesis Negative Regulation Of Monocyte Differentiation Leukocyte Activation Cell Dedifferentiation Cell Activation Response To External Biotic Stimulus Cellular Response To Camptothecin Protein Ubiquitination Modification-dependent Protein Catabolic Process Cytoplasmic Side Of Early Endosome Membrane Lsm1-7-Pat1 Complex Dendritic Cell Proliferation Leukocyte Proliferation Mononuclear Cell Proliferation Positive Regulation Of T Cell Anergy CXCL12-activated CXCR4 Signaling Pathway T Cell Tolerance Induction T Cell Anergy Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation C-X-C Chemokine Receptor CXCR4 Signaling Pathway Early Endosome Membrane Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Regulation Of T Cell Anergy Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Receptor Catabolic Process CD4-positive, Alpha-beta T Cell Proliferation Arrestin Family Protein Binding Positive Regulation Of T Cell Tolerance Induction Lateral Ventricle Development Type B Pancreatic Cell Development Post-translational Protein Modification	Clathrin Binding Polyubiquitin Modification-dependent Protein Binding Cytosol Ubiquitin Binding Regulation Of Macroautophagy Autophagy Clathrin Vesicle Coat Autophagosome Regulation Of Signal Transduction Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Phosphatidylinositol Binding Positive Regulation Of Catabolic Process Endocytosis Vesicle-mediated Transport Establishment Of Protein Localization To Vacuole ESCRT-0 Complex Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Metabolic Process Cytoplasm Cytoplasmic Vesicle Regulation Of Protein Catabolic Process Regulation Of Autophagy Macroautophagy Protein Targeting To Lysosome Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Localization To Vacuole Endosome Positive Regulation Of Macroautophagy Positive Regulation Of Autophagosome Maturation Import Into Cell Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Early Endosome Membrane Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Phospholipid Binding Protein Transport Protein Targeting To Vacuole Regulation Of Protein Deubiquitination Protein Binding Protein Localization To Lysosome Positive Regulation Of Nucleocytoplasmic Transport Protein-containing Complex Negative Regulation Of Signal Transduction Regulation Of Potassium Ion Transmembrane Transport Protein Tag Activity Regulation Of Autophagosome Maturation