CEBPZ and LAG3

Number of citations: 0 (PubMedID 11592063)
Data Source: HPRD (two hybrid, in vitro)

		CEBPZ	LAG3
Name		CCAAT enhancer binding protein zeta	lymphocyte activating 3
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm CCAAT-binding Factor Complex	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding	Antigen Binding Transmembrane Signaling Receptor Activity Protein Binding MHC Class II Protein Binding
	Biological Process	Positive Regulation Of Transcription By RNA Polymerase II	Adaptive Immune Response Plasmacytoid Dendritic Cell Activation Immune System Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production T Cell Activation Natural Killer Cell Mediated Cytotoxicity Innate Immune Response Negative Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Negative Regulation Of T Cell Activation
Pathways		None	MHC class II antigen presentation
Drugs		None	Relatlimab
GWAS		Schizophrenia ( 23974872 )	Blood protein levels ( 30072576 )
Novel Interactors		None recorded	5 novel interactors: ALCAM CLEC4D GNAI2 KCNA1 UBE2E3
Interacting Genes		18 interacting genes: CRYAA GSK3B HMOX2 LAG3 LAMTOR3 LTB4R2 LZTR1 MFHAS1 NFYB PCBD1 PRKRA RNF10 RPS6KA6 RXRG STAT6 TP53 TP73 UBE3A	2 interacting genes: CEBPZ CPAP
Entrez ID		10153	3902
HPRD ID		09875	01077
Ensembl ID		ENSG00000115816	ENSG00000089692
Uniprot IDs		Q03701	P18627
PDB IDs		Not available	7TZG 7TZH 7UM3 8SO3 8SR0 9BF9
GO Terms Enriched among Interactors		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II P53 Binding ER Overload Response Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Intrinsic Apoptotic Signaling Pathway MDM2/MDM4 Family Protein Binding TOR Signaling Positive Regulation Of Intracellular Signal Transduction Mitochondrion Organization Negative Regulation Of Cell Development Transcription Cis-regulatory Region Binding Regulation Of Gliogenesis Regulation Of Regulatory NcRNA Processing Signal Transduction By P53 Class Mediator Negative Regulation Of Glial Cell Proliferation Regulation Of Circadian Rhythm Signal Transduction Intracellular Signal Transduction Release Of Cytochrome C From Mitochondria Negative Regulation Of Developmental Process RNA Polymerase II Transcription Regulator Complex Response To Stress Response To Oxidative Stress Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Membrane Permeability Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity T Cell Lineage Commitment Protein Phosphatase 2A Binding Positive Regulation Of Apoptotic Signaling Pathway Regulation Of TOR Signaling Negative Regulation Of Cell Differentiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Nucleoplasm Regulation Of Gene Expression Negative Regulation Of Catalytic Activity ER-nucleus Signaling Pathway Regulation Of Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Signal Transduction Negative Regulation Of Multicellular Organismal Process Regulation Of Microtubule Anchoring At Centrosome RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific	None