CEBPZ and PRKRA

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		CEBPZ	PRKRA
Description		CCAAT enhancer binding protein zeta	protein activator of interferon induced protein kinase EIF2AK2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm CCAAT-binding Factor Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane RISC Complex Perinuclear Region Of Cytoplasm RISC-loading Complex
	Molecular Function	DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding	RNA Binding Double-stranded RNA Binding Protein Binding Enzyme Activator Activity Enzyme Binding Protein Kinase Activator Activity SiRNA Binding Identical Protein Binding Protein Homodimerization Activity Pre-miRNA Binding
	Biological Process	Positive Regulation Of Transcription By RNA Polymerase II	Immune Response Negative Regulation Of Cell Population Proliferation Response To Virus SiRNA Processing Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing Cellular Response To Oxidative Stress MiRNA Processing Outer Ear Morphogenesis Middle Ear Morphogenesis Ear Development Skeletal System Morphogenesis Protein Stabilization Regulation Of Regulatory NcRNA Processing RISC Complex Assembly Antiviral Innate Immune Response Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis PKR-mediated signaling
Drugs
Diseases			Primary torsion dystonia (PTD)
GWAS		Schizophrenia ( 23974872)	Inflammatory skin disease ( 25574825) Multiple sclerosis (OCB status) ( 23472185) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183)
Interacting Genes		18 interacting genes: CRYAA GSK3B HMOX2 LAG3 LAMTOR3 LTB4R2 LZTR1 MFHAS1 NFYB PCBD1 PRKRA RNF10 RPS6KA6 RXRG STAT6 TP53 TP73 UBE3A	29 interacting genes: ADARB1 AGO2 CEBPZ CEP126 COPS6 DICER1 EHHADH EIF2AK2 GDF9 H19 LNX1 LYAR NEIL3 NKRF PIAS2 PNPT1 POLR2G RABEPK RB1 RBPMS SETDB1 SHC1 SNX5 TARBP2 TIRAP TP53 ZFP28 ZMAT3 ZNF746
Entrez ID		10153	8575
HPRD ID		09875	04573
Ensembl ID		ENSG00000115816	ENSG00000180228
Uniprot IDs		Q03701	A0A7I2V2I8 A0A7I2V5H3 B4DJC7 O75569
PDB IDs			2DIX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II P53 Binding ER Overload Response Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Intrinsic Apoptotic Signaling Pathway MDM2/MDM4 Family Protein Binding TOR Signaling Positive Regulation Of Intracellular Signal Transduction Mitochondrion Organization Negative Regulation Of Cell Development Transcription Cis-regulatory Region Binding Regulation Of Gliogenesis Regulation Of Regulatory NcRNA Processing Signal Transduction By P53 Class Mediator Negative Regulation Of Glial Cell Proliferation Regulation Of Circadian Rhythm Signal Transduction Intracellular Signal Transduction Release Of Cytochrome C From Mitochondria Negative Regulation Of Developmental Process RNA Polymerase II Transcription Regulator Complex Response To Stress Response To Oxidative Stress Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Membrane Permeability Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity T Cell Lineage Commitment Protein Phosphatase 2A Binding Positive Regulation Of Apoptotic Signaling Pathway Regulation Of TOR Signaling Negative Regulation Of Cell Differentiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Nucleoplasm Regulation Of Gene Expression Negative Regulation Of Catalytic Activity ER-nucleus Signaling Pathway Regulation Of Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Signal Transduction Negative Regulation Of Multicellular Organismal Process Regulation Of Microtubule Anchoring At Centrosome RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific	Double-stranded RNA Binding RISC-loading Complex SiRNA Processing RISC Complex Assembly SiRNA Binding Negative Regulation Of Macromolecule Metabolic Process Pre-miRNA Processing Positive Regulation Of RNA Metabolic Process Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Global Gene Silencing By MRNA Cleavage Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleic Acid Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process RNA Binding Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Regulation Of Macromolecule Metabolic Process Glial Cell Apoptotic Process Positive Regulation Of Macromolecule Metabolic Process MiRNA Processing Regulation Of Gene Expression MiRNA Binding Negative Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gliogenesis Regulation Of Glial Cell Proliferation Identical Protein Binding Pre-miRNA Binding Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Nucleoplasm Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Receptor Tyrosine Kinase Binding Negative Regulation Of Catalytic Activity Negative Regulation Of Phosphate Metabolic Process Regulation Of MiRNA Processing Regulation Of Regulatory NcRNA Processing
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