PRR16 and PPP1CC

Number of citations of the paper that reports this interaction (PubMedID 23080069)
0

Data Source:
BioGRID (two hybrid)

		PRR16	PPP1CC
Description		proline rich 16	protein phosphatase 1 catalytic subunit gamma
Image		No pdb structure
GO Annotations	Cellular Component		Chromosome, Centromeric Region Kinetochore Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Microtubule Organizing Center Cytosol Cytoskeleton Focal Adhesion Nuclear Speck Midbody Cleavage Furrow Protein-containing Complex Dendritic Spine PTW/PP1 Phosphatase Complex Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding	RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Lamin Binding Protein Phosphatase 1 Binding Hydrolase Activity Phosphatase Activity Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Translation Positive Regulation Of Cell Size	Mitotic Sister Chromatid Segregation MAPK Cascade Blastocyst Development Glycogen Metabolic Process Protein Dephosphorylation Spermatogenesis Neuron Differentiation Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Regulation Of Nucleocytoplasmic Transport Rhythmic Process Cell Division Positive Regulation Of Glial Cell Proliferation
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Triglyceride catabolism Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins RAF activation Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling Maturation of hRSV A proteins Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs			9,10-Deepithio-9,10-Didehydroacanthifolicin Calyculin A Motuporin
Diseases
GWAS		Adult body size ( 32376654) Age-related cognitive decline (global cognition) (slope of z-scores) ( 30954325) Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Body mass index (change over time) ( 25133637) Bronchopulmonary dysplasia ( 23897914) Cognitive decline rate in late mild cognitive impairment ( 26252872) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) Loneliness (linear analysis) ( 27629369) Numerical cognitive ability ( 31620175) Pulse pressure ( 30224653) Verbal cognitive ability ( 31620175) Verbal declarative memory ( 25648963) Weight ( 28552196)	Heart rate ( 23583979)
Interacting Genes		11 interacting genes: ABI2 APP DAPK1 DLG4 NCK2 NEDD4 NEDD4L NOD2 PPP1CA PPP1CC SMURF1	128 interacting genes: ABT1 ACAD8 AKAP11 ANKRD42 APIP APP ASH2L AURKA B4GAT1 BMPR2 BTBD10 C14orf180 C1QA C9orf50 CEP126 CLMN CLOCK CLTC CNST COPS5 CSNK1A1 CSNK1E CSNK2B CSRNP2 CTSL CYFIP1 DACT1 DEAF1 DELEC1 DYNLT4 DYRK4 EIF2AK2 ELP4 ENKD1 FBXW11 FTL FXYD6 GLB1L GOLGA7 GSTZ1 HCFC1 HDAC6 HMGN1 IFTAP IL3RA INSYN1 IRAK1 JAK2 KCTD20 KDM4D KRCC1 LMTK2 MAP4K4 MAPT MYO16 NAPEPLD NEK2 NMT2 NONO NRBP1 NUAK1 PHACTR4 PHC1 PIAS1 POLR1F PPP1R11 PPP1R15B PPP1R16A PPP1R18 PPP1R2 PPP1R2B PPP1R2C PPP1R35 PPP1R3A PPP1R3C PPP1R3D PPP1R7 PPP1R8 PPP1R9A PPP2R5C PRR16 RAF1 RB1 RIF1 RNF19B RORC RPL7 RPRD2 RRM1 RRP1B SAXO4 SDR39U1 SFRP1 SGCE SH3RF2 SHANK3 SMARCB1 SMG6 SPATC1L SPOCD1 STAM STARD9 SUMO2 TACC2 TBC1D19 TEFM TEX36 TLX1 TLX3 TMEM120A TNS1 TOPBP1 TOR1AIP1 TP53 TP53BP2 TPRN TRA2A VCP VSTM4 WBP11 YLPM1 YWHAZ ZDBF2 ZFYVE9 ZNF24 ZNF318 ZNF629 ZNF667
Entrez ID		51334	5501
HPRD ID		14239	08911
Ensembl ID		ENSG00000184838	ENSG00000186298
Uniprot IDs		Q569H4	P36873
PDB IDs			1IT6 1JK7 1U32 2BCD 2BDX 4UT2 4UT3 5INB 5J28 7SD0 8B5R
Enriched GO Terms of Interacting Partners?		Dendritic Spine Receptor Catabolic Process Positive Regulation Of Catabolic Process Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cell Projection Organization Protein Modification Process Protein-containing Complex Binding Positive Regulation Of Cellular Component Organization Receptor Metabolic Process NMDA Selective Glutamate Receptor Signaling Pathway Negative Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Protein Metabolic Process PTW/PP1 Phosphatase Complex Sodium Channel Inhibitor Activity Presynapse Postsynapse Potassium Channel Inhibitor Activity Regulation Of Translational Initiation In Response To Stress Glutamatergic Synapse Regulation Of Potassium Ion Export Across Plasma Membrane Protein Polyubiquitination Acetylcholine Receptor Binding Regulation Of Synapse Organization Cell Projection Organization Negative Regulation Of Sodium Ion Transport Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Response To Light Stimulus Response To Metal Ion Response To Lead Ion Transition Metal Ion Binding Positive Regulation Of Dendrite Extension Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Translation In Response To Stress Cytoskeletal Anchor Activity Macromolecule Metabolic Process Entrainment Of Circadian Clock By Photoperiod Positive Regulation Of Apoptotic Signaling Pathway Protein Phosphatase 1 Binding Regulation Of Translation Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neuron Projection Development Photoperiodism Entrainment Of Circadian Clock Ionotropic Glutamate Receptor Signaling Pathway Plasma Membrane Bounded Cell Projection Organization Regulation Of Membrane Potential Positive Regulation Of Supramolecular Fiber Organization Response To Radiation	Protein Phosphatase 1 Binding Protein Phosphatase Inhibitor Activity Phosphatase Binding Protein Phosphatase Regulator Activity Protein Serine/threonine Kinase Activity Protein Phosphorylation Protein Serine/threonine Phosphatase Inhibitor Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Phosphatase Type 1 Complex Phosphorylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Viral Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Regulation Of Proteolysis Macromolecule Metabolic Process Nucleoplasm Protein Kinase Activity Positive Regulation Of Proteasomal Protein Catabolic Process Inclusion Body Assembly Glycogen Binding Disordered Domain Specific Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Generation Of Precursor Metabolites And Energy Microglial Cell Activation Protein Serine Kinase Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Phosphatase Binding Nucleus Glycogen Metabolic Process Leukocyte Activation Involved In Inflammatory Response Chromatin Remodeling Actin Binding Regulation Of Protein Metabolic Process Regulation Of Primary Metabolic Process Chromatin Organization Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process PML Body Type II Interferon-mediated Signaling Pathway Germ Cell Nucleus Polysaccharide Metabolic Process Regulation Of Circadian Rhythm Energy Reserve Metabolic Process Epigenetic Regulation Of Gene Expression DNA Damage Response Positive Regulation Of Nucleobase-containing Compound Metabolic Process Astrocyte Activation
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