YAF2 and MYCN

Number of citations of the paper that reports this interaction (PMID 11593398)
2

Data Source:
HPRD (two hybrid, in vitro)

		YAF2	MYCN
Gene Name		YY1 associated factor 2	v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Chromatin Nucleus
	Molecular Function	Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Dimerization Activity
	Biological Process	Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated	Cartilage Condensation Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Death Lung Development Embryonic Digit Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Skeletal System Morphogenesis Negative Regulation Of Astrocyte Differentiation Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Drugs
Diseases
GWAS			Pulmonary function (interaction) ( 23284291) Wilms tumor ( 22544364)
Protein-Protein Interactions		6 interactors: GABPB1 MYCN RING1 SETBP1 YY1 ZFP42	12 interactors: CSNK2A1 CSNK2A2 MAX MXD1 NEDD4 NMI PIAS2 SIRT1 SP1 TRIM32 YAF2 YEATS4
Entrez ID		10138	4613
HPRD ID		09606	01278
Ensembl ID		ENSG00000015153	ENSG00000134323
Uniprot IDs		Q8IY57	P04198 Q53XS5
PDB IDs		2D9G
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Camera-type Eye Morphogenesis Regulation Of Gene Expression Response To Prostaglandin F Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Eye Morphogenesis RNA Biosynthetic Process Organ Morphogenesis Anterior/posterior Pattern Specification Organ Development Organelle Organization RNA Metabolic Process Regulation Of Genetic Imprinting Gene Expression Response To UV-C Camera-type Eye Development Cellular Macromolecule Biosynthetic Process Histone H2A Monoubiquitination Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Eye Development Histone H2A Ubiquitination Regulation Of Metabolic Process Negative Regulation Of Astrocyte Differentiation Pattern Specification Process Regulation Of Transcription From RNA Polymerase II Promoter System Development Spermatogenesis Male Gamete Generation Histone Monoubiquitination Cartilage Condensation Nucleobase-containing Compound Metabolic Process Sensory Organ Development Negative Regulation Of Cellular Metabolic Process Regulation Of Astrocyte Differentiation Multicellular Organismal Development Heterocycle Metabolic Process Gamete Generation Cellular Aromatic Compound Metabolic Process Biosynthetic Process Histone Ubiquitination Anatomical Structure Development Negative Regulation Of Glial Cell Differentiation Cellular Nitrogen Compound Metabolic Process Protein Monoubiquitination Anatomical Structure Morphogenesis	Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated RNA Metabolic Process Gene Expression Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Catabolic Process Cellular Metabolic Process Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signal Transduction Regulation Of Chromosome Organization Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Signaling Mitotic Spindle Checkpoint Protein Modification By Small Protein Conjugation Regulation Of Growth Negative Regulation Of Chromosome Segregation Regulation Of Proteolysis Peptidyl-lysine Modification Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Cellular Process Positive Regulation Of Transcription, DNA-templated Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Biosynthetic Process Cellular Protein Modification Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Tagcloud ?		antagonized c2 calpain cdna cloning eliminated encodes finger fingers greatly isolation mapping message myoblasts myogenic normally potentiates promyogenic proteolysis proteolytic restricted reverses sarcomeric stimulates stimulatory termed x10 yy1 zinc	1p36 cdc2l cdc2l1 cdc2l2 conservative cpg1 cpg2 d1z2 delineated duplicated flanking introns melanomas metalloprotease mmp21 mmp22 neuroblastomas nonconservative organized pitslre polymorphic reiterated span specified translocated ubiquitously untranslated ut vntr
Tagcloud (Difference) ?		antagonized c2 calpain cdna cloning eliminated encodes finger fingers greatly isolation mapping message myoblasts myogenic normally potentiates promyogenic proteolysis proteolytic restricted reverses sarcomeric stimulates stimulatory termed x10 yy1 zinc	1p36 cdc2l cdc2l1 cdc2l2 conservative cpg1 cpg2 d1z2 delineated duplicated flanking introns melanomas metalloprotease mmp21 mmp22 neuroblastomas nonconservative organized pitslre polymorphic reiterated span specified translocated ubiquitously untranslated ut vntr
Tagcloud (Intersection) ?