YAF2 and PCDH17

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		YAF2	PCDH17
Description		YY1 associated factor 2	protocadherin 17
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Plasma Membrane Membrane Presynaptic Membrane Postsynaptic Membrane Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Calcium Ion Binding Protein Binding Cell Adhesion Molecule Binding
	Biological Process	Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Adult Behavior Negative Regulation Of Synaptic Transmission Synaptic Membrane Adhesion Presynaptic Active Zone Assembly Regulation Of Synaptic Vesicle Clustering
Pathways		RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Adult body size ( 32376654) Body mass index ( 25673413) Body size at age 10 ( 32376654) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive function ( 25644384) Diastolic blood pressure ( 30224653) Diverticular disease ( 30177863) Experiencing mood swings ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) Fish- and plant-related diet ( 32066663) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Mood instability ( 31168069) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Regular attendance at a religious group ( 29970889) Subcutaneous adipose tissue ( 26480920 22589738) Type 2 diabetes ( 30297969)
Interacting Genes		28 interacting genes: ANP32B CAVIN1 CD300LF DNAAF6 EAF1 GABPB1 IFT57 INO80B LGALS7 LGALS7B MAPRE3 MARK1 MYC MYCN NEDD8 NUTF2 PCDH17 POLR3GL PPP1R11 PTEN SETBP1 SPANXN2 SPANXN3 TLK1 UBC XAGE1B YY1 ZFP42	6 interacting genes: NR1H2 SIAH1 TSC22D4 UBQLN4 YAF2 ZP3
Entrez ID		10138	27253
HPRD ID		09606	15104
Ensembl ID		ENSG00000015153	ENSG00000118946
Uniprot IDs		B4DJQ9 G3V212 Q8IY57	O14917
PDB IDs		2D9G	6VFT
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of MiRNA Transcription Positive Regulation Of Telomere Maintenance Protein Tag Activity Regulation Of Synaptic Vesicle Clustering Regulation Of DNA Strand Elongation Ino80 Complex Positive Regulation Of Telomere Maintenance In Response To DNA Damage Chromatin Organization Regulation Of MiRNA Metabolic Process	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of DNA-templated Transcription Positive Regulation Of High-density Lipoprotein Particle Assembly Regulation Of High-density Lipoprotein Particle Assembly Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Pancreatic Juice Secretion Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Type IV Hypersensitivity Egg Coat Formation Positive Regulation Of Antral Ovarian Follicle Growth Structural Constituent Of Egg Coat Regulation Of Acrosomal Vesicle Exocytosis Negative Regulation Of Autophagosome Maturation Nuclear Proteasome Complex Apolipoprotein A-I Receptor Binding Acrosin Binding Negative Regulation Of Binding Of Sperm To Zona Pellucida Egg Coat Regulation Of Type IV Hypersensitivity Negative Regulation Of Metabolic Process Negative Regulation Of Pinocytosis Regulation Of Binding Of Sperm To Zona Pellucida Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Ovarian Follicle Development Cytosolic Proteasome Complex Negative Regulation Of Type II Interferon-mediated Signaling Pathway Positive Regulation Of Hypersensitivity Negative Regulation Of Immune Response Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Acrosome Reaction Negative Regulation Of Cholesterol Storage K48-linked Polyubiquitin Modification-dependent Protein Binding
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