TRAP1 and IFT140

		TRAP1	IFT140
Description		TNF receptor associated protein 1	intraflagellar transport 140
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Membrane Intracellular Organelle Lumen	Nucleoplasm Cytoplasm Mitochondrion Centrosome Centriole Cytoskeleton Cilium Axoneme Intraciliary Transport Particle A Photoreceptor Connecting Cilium Ciliary Basal Body Cell Projection Ciliary Tip Non-motile Cilium Cone Photoreceptor Outer Segment
	Molecular Function	Nucleotide Binding RNA Binding Tumor Necrosis Factor Receptor Binding Protein Binding ATP Binding ATP Hydrolysis Activity Protein Kinase Binding Unfolded Protein Binding ATP-dependent Protein Folding Chaperone	Protein Binding
	Biological Process	Protein Folding Translational Attenuation Negative Regulation Of Cellular Respiration Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide	Determination Of Left/right Symmetry Heart Development Regulation Of Smoothened Signaling Pathway Neural Tube Patterning Cell Projection Organization Embryonic Camera-type Eye Development Limb Morphogenesis Intraciliary Retrograde Transport Photoreceptor Cell Outer Segment Organization Intraciliary Transport Embryonic Digit Morphogenesis Embryonic Cranial Skeleton Morphogenesis Cilium Assembly Protein Localization To Cilium Regulation Of Cilium Assembly Non-motile Cilium Assembly Embryonic Brain Development
Pathways		Respiratory electron transport Citric acid cycle (TCA cycle)	Hedgehog 'off' state Intraflagellar transport
Drugs
Diseases
GWAS		Asthma ( 32296059) Estimated glomerular filtration rate ( 31152163 31451708) Granulocyte count ( 27863252) Infliximab-induced mucosal healing in Crohn's disease ( 31039275) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 27863252 32888494)	Coronary artery disease ( 29212778 33020668) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383)
Interacting Genes		17 interacting genes: APP ESX1 EXT1 EXT2 FXR1 HGS MCPH1 PSMC4 PTGER4 RB1 SMAD4 TGFBR1 TGFBR2 TLR1 TLR6 TNFRSF1A TPM3	5 interacting genes: CELSR3 CRK NEK2 PFDN1 RANBP2
Entrez ID		10131	9742
HPRD ID		05868	11093
Ensembl ID		ENSG00000126602	ENSG00000187535
Uniprot IDs		A0A140VJY2 Q12931 Q53FS6	Q96RY7
PDB IDs		4Z1F 4Z1G 4Z1H 4Z1I 5F3K 5F5R 5HPH 5Y3N 5Y3O 6XG6 7C04 7C05 7C7B 7C7C 7KCK 7KCL 7KCM 7KLU 7KLV 7U8U 7U8V 7U8W 7U8X 7ULK	8BBF 8BBG 8FGW 8FH3
Enriched GO Terms of Interacting Partners?		Membrane Raft Receptor Complex Regulation Of Inflammatory Response Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Defense Response Negative Regulation Of Multicellular Organismal Process N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity Heparan Sulfate N-acetylglucosaminyltransferase Activity Regulation Of Extracellular Matrix Organization Cell Activation Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity Positive Regulation Of Extracellular Matrix Organization Transforming Growth Factor Beta Ligand-receptor Complex Microglial Cell Activation Activin Receptor Signaling Pathway Embryonic Cranial Skeleton Morphogenesis Mesenchymal Cell Differentiation Leukocyte Activation Involved In Inflammatory Response Regulation Of Signal Transduction Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Toll-like Receptor 2 Binding Detection Of Bacterial Lipoprotein Myeloid Leukocyte Activation Ventricular Septum Morphogenesis Chondrocyte Hypertrophy Animal Organ Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Gene Expression Endochondral Bone Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Multicellular Organismal Process Gastrulation SMAD Binding Protein Heterodimerization Activity Heparin Proteoglycan Biosynthetic Process Activin Receptor Complex Activin Receptor Activity, Type I Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Inflammatory Response Regulation Of Tumor Necrosis Factor Production Sebaceous Gland Development Transforming Growth Factor Beta Receptor Activity Lipopeptide Binding Developmental Process Chondrocyte Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition	Protein Folding Negative Regulation Of Innate Immune Response Protein Localization To Membrane Unfolded Protein Binding Protein-containing Complex Binding Molecular Adaptor Activity Negative Regulation Of Immune Response Localization Within Membrane Helper T Cell Diapedesis Cerebellar Neuron Development Protein Phosphorylated Amino Acid Binding Negative Regulation Of Defense Response Neuromuscular Junction Response To Cholecystokinin Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Negative Regulation Of Centriole-centriole Cohesion Regulation Of Centriole-centriole Cohesion Intercellular Bridge Cytoplasmic Periphery Of The Nuclear Pore Complex IkappaB Kinase Complex Binding Type II Interferon Receptor Binding Positive Regulation Of Type III Interferon Production Type 3 Metabotropic Glutamate Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Protein Localization To Cleavage Furrow 'de Novo' Cotranslational Protein Folding TTT Hsp90 Cochaperone Complex Translational Attenuation
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