LRPPRC and PPARGC1A

Number of citations of the paper that reports this interaction (PMID 17050673)
34

Data Source:
BioGRID (pull down, pull down, affinity chromatography technology)

		LRPPRC	PPARGC1A
Gene Name		leucine-rich pentatricopeptide repeat containing	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Nuclear Chromosome Nucleus Nuclear Inner Membrane Nuclear Outer Membrane Nucleoplasm Mitochondrion Cytoskeleton Microtubule Membrane Ribonucleoprotein Complex Mitochondrial Nucleoid Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm DNA-directed RNA Polymerase II, Core Complex Cytosol PML Body
	Molecular Function	Single-stranded DNA Binding RNA Binding Protein Binding Microtubule Binding Poly(A) RNA Binding Beta-tubulin Binding Actin Filament Binding	Nucleotide Binding RNA Polymerase II Transcription Cofactor Activity DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding Ligand-dependent Nuclear Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Chromatin DNA Binding Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding Androgen Receptor Binding
	Biological Process	Negative Regulation Of Mitochondrial RNA Catabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Mitochondrion Transport Along Microtubule MRNA Transport Regulation Of Mitochondrial Translation	Temperature Homeostasis Cellular Glucose Homeostasis Galactose Metabolic Process Gluconeogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter MRNA Processing Protein Complex Assembly Organelle Organization Mitochondrion Organization Digestion Circadian Rhythm Androgen Metabolic Process RNA Splicing Response To Cold Positive Regulation Of Mitochondrion Organization Response To Muscle Activity Fatty Acid Oxidation Respiratory Electron Transport Chain Androgen Receptor Signaling Pathway Circadian Regulation Of Gene Expression Cellular Response To Oxidative Stress Positive Regulation Of Histone Acetylation Response To Statin Response To Starvation Regulation Of Circadian Rhythm Response To Leucine Negative Regulation Of Neuron Apoptotic Process Cellular Respiration Positive Regulation Of Gluconeogenesis Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fatty Acid Oxidation Positive Regulation Of Smooth Muscle Cell Proliferation Protein Stabilization Brown Fat Cell Differentiation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Flavone Metabolic Process Cellular Response To Nitrite Cellular Response To Tumor Necrosis Factor Cellular Response To Fatty Acid Cellular Response To Hypoxia Response To Epinephrine Response To Norepinephrine Cellular Response To Thyroid Hormone Stimulus Negative Regulation Of Neuron Death Positive Regulation Of Cellular Respiration Positive Regulation Of Mitochondrial DNA Metabolic Process Positive Regulation Of Muscle Tissue Development Negative Regulation Of Receptor Activity Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Energy Homeostasis Positive Regulation Of ATP Biosynthetic Process
Pathways		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport Orphan transporters	PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Activation of PPARGC1A (PGC-1alpha) by phosphorylation Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS			Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		7 interactors: CECR2 FOXO1 HEBP2 MAP1S NFKBIB PPARGC1A UXT	40 interactors: CAPNS1 CDK6 CREBBP CREBZF ESR1 ESR2 ESRRA ESRRG FBXW7 GSK3B HCFC1 HNF4A LRPPRC MAPK14 MED1 MED12 MED14 MED17 MYBBP1A NCL NCOA1 NCOA6 NR1H4 NR1I2 NR1I3 NR3C1 NRF1 PPARA PPARD PPARG RXRA SIRT1 SRSF4 SRSF5 SRSF6 THRB TP53 UBC UBE2I USF2
Entrez ID		10128	10891
HPRD ID		06343	05155
Ensembl ID		ENSG00000138095	ENSG00000109819
Uniprot IDs		E5KNY5 P42704	I3RTT5 I3RTT6 Q9UBK2
PDB IDs			1XB7 3B1M 3CS8 3D24 3U9Q 3V9T 3V9V
Enriched GO Terms of Interacting Partners?		Regulation Of Energy Homeostasis Mitochondrion Transport Along Microtubule Establishment Of Mitochondrion Localization Positive Regulation Of Gluconeogenesis Apoptotic DNA Fragmentation Cellular Response To Reactive Nitrogen Species Temperature Homeostasis Apoptotic Nuclear Changes Positive Regulation Of Glucose Metabolic Process Mitochondrion Localization Regulation Of Gluconeogenesis Organelle Transport Along Microtubule Response To Cold Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Cellular Glucose Homeostasis Cellular Response To Nitrite DNA Catabolic Process, Endonucleolytic Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Glucose Metabolic Process Cellular Response To Oxygen Levels Cellular Nitrogen Compound Metabolic Process Fat Cell Differentiation Positive Regulation Of ATP Biosynthetic Process Positive Regulation Of Mitochondrial DNA Metabolic Process Microtubule-based Transport Organelle Organization Cytoskeleton-dependent Intracellular Transport DNA Catabolic Process Cellular Response To Inorganic Substance Regulation Of Carbohydrate Metabolic Process Response To Statin Positive Regulation Of Energy Homeostasis Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Respiration Response To Starvation Response To Temperature Stimulus Negative Regulation Of Mitochondrial Membrane Potential Cellular Response To Oxidative Stress Transcription From RNA Polymerase II Promoter Glucose Homeostasis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Flavone Metabolic Process Response To Norepinephrine Cellular Response To Cold Response To Leucine Multicellular Organismal Homeostasis Apoptotic Process	Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Hormone-mediated Signaling Pathway Steroid Hormone Mediated Signaling Pathway RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Gene Expression Cellular Response To Steroid Hormone Stimulus Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Steroid Hormone Cellular Nitrogen Compound Metabolic Process Cellular Response To Lipid Biosynthetic Process Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Organic Cyclic Compound Regulation Of Metabolic Process Response To Hormone Negative Regulation Of Biosynthetic Process Response To Lipid Cellular Response To Hormone Stimulus Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Organic Cyclic Compound Cellular Response To Organic Substance Response To Organic Substance
Tagcloud ?		adenocarcinomas autophagic autophagosomal autophagy biogenesis bridges c19orf5 collaboration collaboratively diethylnitrosamine guangzhou h2ax hepatocelular immunochemical inc map1a map1b map1s microtubules mitochondrion named originally p62 pca periodicals survive vary wildtype wiley	ageing bisulfite chosen coefficients concordance cord d4z4 environage epigenetics foetal loop methylation mitochondrial mt nineteen ninety placenta placental pyrosequencing ranging reproductive rnr1 scheme sides signature sirt1 subtelomeric tfam
Tagcloud (Difference) ?		adenocarcinomas autophagic autophagosomal autophagy biogenesis bridges c19orf5 collaboration collaboratively diethylnitrosamine guangzhou h2ax hepatocelular immunochemical inc map1a map1b map1s microtubules mitochondrion named originally p62 pca periodicals survive vary wildtype wiley	ageing bisulfite chosen coefficients concordance cord d4z4 environage epigenetics foetal loop methylation mitochondrial mt nineteen ninety placenta placental pyrosequencing ranging reproductive rnr1 scheme sides signature sirt1 subtelomeric tfam
Tagcloud (Intersection) ?