LRPPRC and FOXO1

Number of citations of the paper that reports this interaction (PMID 17050673)
34

Data Source:
BioGRID (pull down)

		LRPPRC	FOXO1
Gene Name		leucine-rich pentatricopeptide repeat containing	forkhead box O1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Nuclear Chromosome Nucleus Nuclear Inner Membrane Nuclear Outer Membrane Nucleoplasm Mitochondrion Cytoskeleton Microtubule Membrane Ribonucleoprotein Complex Mitochondrial Nucleoid Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Single-stranded DNA Binding RNA Binding Protein Binding Microtubule Binding Poly(A) RNA Binding Beta-tubulin Binding Actin Filament Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Protein Binding Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding Protein Phosphatase 2A Binding
	Biological Process	Negative Regulation Of Mitochondrial RNA Catabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Mitochondrion Transport Along Microtubule MRNA Transport Regulation Of Mitochondrial Translation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Blood Vessel Development Temperature Homeostasis Cellular Glucose Homeostasis Transcription From RNA Polymerase II Promoter Protein Acetylation Autophagy Apoptotic Process Cellular Response To DNA Damage Stimulus Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Starvation Positive Regulation Of Autophagy Endocrine Pancreas Development Cellular Response To Insulin Stimulus Negative Regulation Of Stress-activated MAPK Cascade Cellular Response To Oxidative Stress Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Innate Immune Response Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Gluconeogenesis Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Cellular Response To Cold Cellular Response To Hyperoxia Cellular Response To Nitric Oxide Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Maintenance Regulation Of Neural Precursor Cell Proliferation Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Energy Homeostasis
Pathways		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport Orphan transporters	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation Regulation of beta-cell development PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome AKT-mediated inactivation of FOXO1A Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR AKT phosphorylates targets in the nucleus Downstream signal transduction Fc epsilon receptor (FCERI) signaling Regulation of gene expression in beta cells Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS			Central corneal thickness ( 20485516 20719862) Corneal structure ( 23291589)
Protein-Protein Interactions		7 interactors: CECR2 FOXO1 HEBP2 MAP1S NFKBIB PPARGC1A UXT	31 interactors: AKT1 AR CEBPB CREBBP CSNK1G1 CTNNB1 DYRK1A EP300 ESR1 FHL2 FOXG1 G6PC GSK3B HNF4A HOXA10 HOXA5 LRPPRC MDM2 MST1 PAK1 PARP1 PPARG RARA SIRT1 SMAD3 SMAD4 SRC THRB TXNRD1 YWHAG YWHAZ
Entrez ID		10128	2308
HPRD ID		06343	00645
Ensembl ID		ENSG00000138095	ENSG00000150907
Uniprot IDs		E5KNY5 P42704	Q12778
PDB IDs			3CO6 3CO7 3COA
Enriched GO Terms of Interacting Partners?		Regulation Of Energy Homeostasis Mitochondrion Transport Along Microtubule Establishment Of Mitochondrion Localization Positive Regulation Of Gluconeogenesis Apoptotic DNA Fragmentation Cellular Response To Reactive Nitrogen Species Temperature Homeostasis Apoptotic Nuclear Changes Positive Regulation Of Glucose Metabolic Process Mitochondrion Localization Regulation Of Gluconeogenesis Organelle Transport Along Microtubule Response To Cold Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Cellular Glucose Homeostasis Cellular Response To Nitrite DNA Catabolic Process, Endonucleolytic Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Glucose Metabolic Process Cellular Response To Oxygen Levels Cellular Nitrogen Compound Metabolic Process Fat Cell Differentiation Positive Regulation Of ATP Biosynthetic Process Positive Regulation Of Mitochondrial DNA Metabolic Process Microtubule-based Transport Organelle Organization Cytoskeleton-dependent Intracellular Transport DNA Catabolic Process Cellular Response To Inorganic Substance Regulation Of Carbohydrate Metabolic Process Response To Statin Positive Regulation Of Energy Homeostasis Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Respiration Response To Starvation Response To Temperature Stimulus Negative Regulation Of Mitochondrial Membrane Potential Cellular Response To Oxidative Stress Transcription From RNA Polymerase II Promoter Glucose Homeostasis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Flavone Metabolic Process Response To Norepinephrine Cellular Response To Cold Response To Leucine Multicellular Organismal Homeostasis Apoptotic Process	Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Response To Hormone Positive Regulation Of Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Cell Death Multicellular Organismal Development Cellular Response To Organic Substance Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Cellular Response To Hormone Stimulus Anatomical Structure Development Regulation Of RNA Metabolic Process Transcription, DNA-templated DNA-templated Transcription, Initiation Regulation Of Apoptotic Process RNA Biosynthetic Process Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process System Development Response To Organic Substance Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Cellular Response To Organic Cyclic Compound Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Developmental Process Organ Development Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Intracellular Receptor Signaling Pathway Gene Expression Regulation Of Signaling Tissue Development Regulation Of Protein Localization Regulation Of Metabolic Process Reproductive Structure Development Epithelium Development Reproductive System Development Transcription From RNA Polymerase II Promoter Regulation Of Establishment Of Protein Localization Epithelial Cell Differentiation Cellular Nitrogen Compound Metabolic Process
Tagcloud ?		adenocarcinomas autophagic autophagosomal autophagy biogenesis bridges c19orf5 collaboration collaboratively diethylnitrosamine guangzhou h2ax hepatocelular immunochemical inc map1a map1b map1s microtubules mitochondrion named originally p62 pca periodicals survive vary wildtype wiley	adipocytes aggressiveness bd box controversial cytoplasm du145 exclusion forkhead immunocytochemistry inactivation invasion leptin lncap longterm ly294002 matrigel nonobese obesity obr pc3 pca pi3k restriction subcellular transfections woundhealing wst
Tagcloud (Difference) ?		adenocarcinomas autophagic autophagosomal autophagy biogenesis bridges c19orf5 collaboration collaboratively diethylnitrosamine guangzhou h2ax hepatocelular immunochemical inc map1a map1b map1s microtubules mitochondrion named originally p62 periodicals survive vary wildtype wiley	adipocytes aggressiveness bd box controversial cytoplasm du145 exclusion forkhead immunocytochemistry inactivation invasion leptin lncap longterm ly294002 matrigel nonobese obesity obr pc3 pi3k restriction subcellular transfections woundhealing wst
Tagcloud (Intersection) ?		pca