LRPPRC and IPO8

Number of citations of the paper that reports this interaction (PubMedID 28325843)
34

Data Source:
BioGRID (pull down)

		LRPPRC	IPO8
Description		leucine rich pentatricopeptide repeat containing	importin 8
Image			No pdb structure
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Nucleus Nuclear Inner Membrane Nuclear Outer Membrane Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Cytoskeleton Microtubule Membrane Mitochondrial Nucleoid Perinuclear Region Of Cytoplasm Ribonucleoprotein Complex	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytosol
	Molecular Function	DNA Binding Single-stranded DNA Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Microtubule Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding Actin Filament Binding	Protein Binding Small GTPase Binding
	Biological Process	Mitochondrial RNA Catabolic Process Negative Regulation Of Mitochondrial RNA Catabolic Process Autophagy Mitochondrion Transport Along Microtubule MRNA Transport Regulation Of Mitochondrial Translation Mitochondrial MRNA Polyadenylation Negative Regulation Of Mitochondrial MRNA Catabolic Process	Protein Import Into Nucleus Intracellular Protein Transport Signal Transduction Protein Transport
Pathways		Mitochondrial RNA degradation Mitochondrial mRNA modification	Transcriptional regulation by small RNAs
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30679032) Alcohol use disorder (consumption score) ( 33861876) Bitter alcoholic beverage consumption ( 31046077) Chronotype ( 30696823) Frailty index ( 34431594) Hand grip strength ( 29313844 29691431) Levodopa-induced dyskinesia in levodopa treated Parkinson's disease ( 32733355) Medication use (calcium channel blockers) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Morning person ( 30696823) Refractive error ( 32231278) Smoking status (ever vs never smokers) ( 30643258)	Initial pursuit acceleration ( 29064472) Initial pursuit acceleration in psychotic disorders ( 29064472) Monocyte count ( 32888494) Order dimension in obsessive compulsive disorder ( 32424139) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417)
Interacting Genes		86 interacting genes: ANKRD1 CECR2 EIF4E FOXO1 HEBP2 IPO8 LINC01554 MAP1S MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NFKBIB PPARGC1A PTEN RNF10 UXT XPO1	12 interacting genes: ATXN1 EIF4E KPNB1 LRPPRC RAN RANGAP1 RNF10 SRP19 WT1 ZFP2 ZNF264 ZNF774
Entrez ID		10128	10526
HPRD ID		06343	09282
Ensembl ID		ENSG00000138095	ENSG00000133704
Uniprot IDs		E5KNY5 P42704	O15397
PDB IDs		8ANY
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Regulation Of Macromolecule Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Cytokine Production Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of Multicellular Organismal Process Regulation Of Translation Regulation Of MRNA Stability Regulation Of RNA Stability Negative Regulation Of Protein Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Cell Migration Extracellular Space Negative Regulation Of Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Motility Negative Regulation Of Endothelial Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus	Nuclear Transport Nucleocytoplasmic Transport Nuclear Export RNA Binding RNA Transport RNA Import Into Nucleus Nucleus Nucleobase-containing Compound Transport Importin-alpha Family Protein Binding Cellular Localization Nuclear Pore Intracellular Transport Cellular Response To Hormone Stimulus DNA Binding Establishment Of Localization In Cell Nuclear Envelope Regulation Of Glial Cell Proliferation Regulation Of RNA Metabolic Process Eukaryotic Initiation Factor 4G Binding Response To Hormone Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Establishment Of Organelle Localization Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Cellular Response To Corticosteroid Stimulus Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding RNA Nuclear Export Complex SnRNA Import Into Nucleus Pre-miRNA Export From Nucleus Cytoplasmic Periphery Of The Nuclear Pore Complex Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Negative Regulation Of Mitochondrial MRNA Catabolic Process Negative Regulation Of Mitochondrial RNA Catabolic Process RNA Export From Nucleus Establishment Of Protein Localization To Organelle Cellular Response To Steroid Hormone Stimulus Cytoplasmic Stress Granule Mitotic Spindle Organization Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Female Gonad Development Negative Regulation Of Glomerular Mesangial Cell Proliferation MRNA Cap Binding Regulation Of Macromolecule Metabolic Process Regulation Of Translation Regulation Of Translation At Postsynapse
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