LRPPRC and CECR2

Number of citations of the paper that reports this interaction (PubMedID 11827465)
60

Data Source:
HPRD (two hybrid)

		LRPPRC	CECR2
Description		leucine rich pentatricopeptide repeat containing	CECR2 histone acetyl-lysine reader
Image
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Nucleus Nuclear Inner Membrane Nuclear Outer Membrane Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Cytoskeleton Microtubule Membrane Mitochondrial Nucleoid Perinuclear Region Of Cytoplasm Ribonucleoprotein Complex	Euchromatin Nucleus ISWI-type Complex CERF Complex
	Molecular Function	DNA Binding Single-stranded DNA Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Microtubule Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding Actin Filament Binding	Protein Binding ATP-dependent Chromatin Remodeler Activity
	Biological Process	Mitochondrial RNA Catabolic Process Negative Regulation Of Mitochondrial RNA Catabolic Process Autophagy Mitochondrion Transport Along Microtubule MRNA Transport Regulation Of Mitochondrial Translation Mitochondrial MRNA Polyadenylation Negative Regulation Of Mitochondrial MRNA Catabolic Process	Neural Fold Formation Neural Tube Closure Apoptotic DNA Fragmentation Chromatin Organization Chromatin Remodeling Cytoskeleton Organization Single Fertilization Vesicle-mediated Transport Neural Tube Development Inner Ear Receptor Cell Stereocilium Organization Cytoskeleton-dependent Cytokinesis Cochlea Development Execution Phase Of Apoptosis
Pathways		Mitochondrial RNA degradation Mitochondrial mRNA modification
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30679032) Alcohol use disorder (consumption score) ( 33861876) Bitter alcoholic beverage consumption ( 31046077) Chronotype ( 30696823) Frailty index ( 34431594) Hand grip strength ( 29313844 29691431) Levodopa-induced dyskinesia in levodopa treated Parkinson's disease ( 32733355) Medication use (calcium channel blockers) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Morning person ( 30696823) Refractive error ( 32231278) Smoking status (ever vs never smokers) ( 30643258)	Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Interacting Genes		86 interacting genes: ANKRD1 CECR2 EIF4E FOXO1 HEBP2 IPO8 LINC01554 MAP1S MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NFKBIB PPARGC1A PTEN RNF10 UXT XPO1	2 interacting genes: LRPPRC UXT
Entrez ID		10128	27443
HPRD ID		06343	10463
Ensembl ID		ENSG00000138095	ENSG00000099954
Uniprot IDs		E5KNY5 P42704	B7WPH3 Q9BXF3
PDB IDs		8ANY	3NXB 5V84 8RU1
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Regulation Of Macromolecule Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Cytokine Production Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of Multicellular Organismal Process Regulation Of Translation Regulation Of MRNA Stability Regulation Of RNA Stability Negative Regulation Of Protein Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Cell Migration Extracellular Space Negative Regulation Of Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Motility Negative Regulation Of Endothelial Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus	Cytoskeleton-dependent Intracellular Transport Mitochondrion Transport Along Microtubule Establishment Of Mitochondrion Localization Beta-tubulin Binding Mitochondrion Localization Organelle Transport Along Microtubule Microtubule-based Process Anterior Visceral Endoderm Cell Migration Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Polarized Secretion Of Basement Membrane Proteins In Epithelium Cell Trailing Edge Transport Along Microtubule Intracellular Transport Negative Regulation Of Mitochondrial MRNA Catabolic Process Negative Regulation Of Mitochondrial RNA Catabolic Process Establishment Of Bipolar Cell Polarity Involved In Cell Morphogenesis Focal Adhesion Disassembly Actin Filament Binding Microtubule-based Transport Extracellular Matrix Constituent Secretion Tear Secretion Negative Regulation Of RNA Metabolic Process Microtubule Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Localization Establishment Of Organelle Localization Establishment Of Localization In Cell Mitochondrial MRNA Polyadenylation Embryonic Nail Plate Morphogenesis Gene Expression Maintenance Of Postsynaptic Density Structure Mitochondrial RNA Catabolic Process Microtubule-based Movement Maintenance Of Postsynaptic Specialization Structure Cornea Development In Camera-type Eye RPAP3/R2TP/prefoldin-like Complex Primitive Streak Formation Microtubule Cytoskeleton Organization Organelle Localization Negative Regulation Of Cardiocyte Differentiation Eyelid Development In Camera-type Eye Regulation Of Postsynaptic Density Assembly Negative Regulation Of Macromolecule Metabolic Process Regulation Of Mitochondrial Translation Post-anal Tail Morphogenesis Embryonic Brain Development Regulation Of Postsynaptic Specialization Assembly Regulation Of Excitatory Synapse Assembly Postsynaptic Density Organization Negative Regulation Of Metabolic Process
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