IPO8 and EIF4E

Number of citations of the paper that reports this interaction (PubMedID 28325843)
34

Data Source:
BioGRID (pull down)

		IPO8	EIF4E
Description		importin 8	eukaryotic translation initiation factor 4E
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytosol	P-body Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Eukaryotic Translation Initiation Factor 4F Complex RISC Complex Nuclear Body Nuclear Speck Chromatoid Body Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Small GTPase Binding	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding Translation Initiation Factor Activity Protein Binding Enzyme Binding Eukaryotic Initiation Factor 4G Binding MRNA Cap Binding DNA-binding Transcription Factor Binding
	Biological Process	Protein Import Into Nucleus Intracellular Protein Transport Signal Transduction Protein Transport	G1/S Transition Of Mitotic Cell Cycle Behavioral Fear Response MRNA Export From Nucleus Translation Translational Initiation Regulation Of Translation Negative Regulation Of Autophagy Negative Regulation Of Translation Stem Cell Population Maintenance Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Mitotic Cell Cycle MRNA Transport Nuclear Export Cellular Response To Dexamethasone Stimulus Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission
Pathways		Transcriptional regulation by small RNAs	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript mTORC1-mediated signalling Deadenylation of mRNA Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Drugs			7-methyl-GpppA 7-methyl-7,8-dihydroguanosine-5'-diphosphate 7-methyl-guanosine-5'-triphosphate LY2275796 S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate
Diseases
GWAS		Initial pursuit acceleration ( 29064472) Initial pursuit acceleration in psychotic disorders ( 29064472) Monocyte count ( 32888494) Order dimension in obsessive compulsive disorder ( 32424139) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417)	Alcohol consumption (drinks per week) ( 30643258 30679032) Alcohol dependence ( 33290381) Daytime sleep phenotypes ( 27126917) HDL cholesterol levels ( 32203549) Mean arterial pressure x educational attainment (graduated college) interaction (2df) ( 32372009) Menopause (age at onset) ( 29773799) Sensation seeking ( 30718321)
Interacting Genes		12 interacting genes: ATXN1 EIF4E KPNB1 LRPPRC RAN RANGAP1 RNF10 SRP19 WT1 ZFP2 ZNF264 ZNF774	38 interacting genes: ACVRL1 APP BIRC2 CD83 CEBPA CPEB1 CYFIP1 EIF4B EIF4EBP1 EIF4EBP2 EIF4EBP3 EIF4ENIF1 EIF4G1 EIF4G2 EIF4G3 EMX2 EN2 GEMIN5 HOXA9 IPO8 KANK2 LRPPRC MAPKAPK5 MKNK1 MKNK2 OTX2 PML PRDM4 PRKCA PRKCB PRKCG PTEN RNMT TDO2 TLX1 TRIM27 UBXN11 XPO1
Entrez ID		10526	1977
HPRD ID		09282	00591
Ensembl ID		ENSG00000133704	ENSG00000151247
Uniprot IDs		O15397	D6RBW1 P06730 Q32Q75 X5D7E3
PDB IDs			1IPB 1IPC 1WKW 2GPQ 2V8W 2V8X 2V8Y 2W97 3AM7 3TF2 3U7X 4AZA 4BEA 4DT6 4DUM 4TPW 4TQB 4TQC 4UED 5EHC 5EI3 5EIR 5EKV 5GW6 5T46 5ZJY 5ZJZ 5ZK5 5ZK7 5ZK9 5ZML 7D6Y 7D8B 7EZW 7F07 7MEU 7XTP 8QM4 8QM5 8QM6 8QM7 8QM8 8QM9 8SX4 9DON
Enriched GO Terms of Interacting Partners?		Nuclear Transport Nucleocytoplasmic Transport Nuclear Export RNA Binding RNA Transport RNA Import Into Nucleus Nucleus Nucleobase-containing Compound Transport Importin-alpha Family Protein Binding Cellular Localization Nuclear Pore Intracellular Transport Cellular Response To Hormone Stimulus DNA Binding Establishment Of Localization In Cell Nuclear Envelope Regulation Of Glial Cell Proliferation Regulation Of RNA Metabolic Process Eukaryotic Initiation Factor 4G Binding Response To Hormone Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Establishment Of Organelle Localization Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Cellular Response To Corticosteroid Stimulus Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding RNA Nuclear Export Complex SnRNA Import Into Nucleus Pre-miRNA Export From Nucleus Cytoplasmic Periphery Of The Nuclear Pore Complex Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Negative Regulation Of Mitochondrial MRNA Catabolic Process Negative Regulation Of Mitochondrial RNA Catabolic Process RNA Export From Nucleus Establishment Of Protein Localization To Organelle Cellular Response To Steroid Hormone Stimulus Cytoplasmic Stress Granule Mitotic Spindle Organization Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Female Gonad Development Negative Regulation Of Glomerular Mesangial Cell Proliferation MRNA Cap Binding Regulation Of Macromolecule Metabolic Process Regulation Of Translation Regulation Of Translation At Postsynapse	Regulation Of Translation Post-transcriptional Regulation Of Gene Expression Regulation Of Protein Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Eukaryotic Initiation Factor 4E Binding Eukaryotic Translation Initiation Factor 4F Complex Regulation Of Translational Initiation Negative Regulation Of Translation Negative Regulation Of Metabolic Process Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Translation Repressor Activity Negative Regulation Of Protein Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Translation Factor Activity, RNA Binding Positive Regulation Of Biosynthetic Process Calcium-dependent Protein Serine/threonine Kinase Activity Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Translation Negative Regulation Of Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Translational Initiation Positive Regulation Of RNA Metabolic Process Protein Metabolic Process Translation Initiation Factor Activity PML Body Histone H3T6 Kinase Activity Cognition Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Macromolecule Metabolic Process Calcium/calmodulin-dependent Protein Kinase Activity Regulation Of Cell Cycle Intracellular Signal Transduction Protein Serine/threonine Kinase Activity Protein Kinase C Signaling Learning Or Memory Translational Initiation
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