RASGRP1 and CD19

Data Source: HiPPIP (Novel)

		RASGRP1	CD19
Name		RAS guanyl releasing protein 1	CD19 molecule
Structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane	Plasma Membrane External Side Of Plasma Membrane Membrane Protein-containing Complex Membrane Raft Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Zinc Ion Binding Lipid Binding Diacylglycerol Binding GTPase Regulator Activity Phosphatidylcholine Binding Identical Protein Binding Metal Ion Binding	None
	Biological Process	Positive Regulation Of Protein Phosphorylation Inflammatory Response To Antigenic Stimulus Positive Regulation Of Immune System Process Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Natural Killer Cell Activation Cell Differentiation Secretory Granule Localization Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus T Cell Proliferation B Cell Proliferation T Cell Activation B Cell Activation Mast Cell Degranulation Positive Regulation Of MAP Kinase Activity Leukocyte Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Ras Protein Signal Transduction Vesicle Transport Along Microtubule Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of ERK1 And ERK2 Cascade Activation Of GTPase Activity Regulation Of Intracellular Signal Transduction	B-1 B Cell Differentiation Adaptive Immune Response B Cell Proliferation Involved In Immune Response Immune System Process Immunoglobulin Mediated Immune Response B Cell Mediated Immunity B Cell Proliferation Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Regulation Of B Cell Activation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		Effects of PIP2 hydrolysis Activation of RAS in B cells Activation of RAS in B cells FCERI mediated NF-kB activation Integrin signaling Rap1 signalling RAF/MAP kinase cascade	PIP3 activates AKT signaling Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Regulation of Complement cascade Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		None	Coltuximab ravtansine Blinatumomab Depatuxizumab mafodotin Inebilizumab Tisagenlecleucel Axicabtagene ciloleucel Tafasitamab Brexucabtagene autoleucel Loncastuximab tesirine Lisocabtagene maraleucel
Diseases		None	Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Autoimmune thyroid disease ( 32581359 ) Autoimmune traits (pleiotropy) ( 30572963 ) Bipolar disorder ( 18711365 ) Carboplatin disposition in epthelial ovarian cancer ( 29367611 ) Crohn's disease ( 23128233 28067908 ) Estimated glomerular filtration rate ( 30604766 ) Glucagon levels in response to oral glucose tolerance test (decremental area under the curve for 0-30 minutes) ( 33407418 ) Medication use (thyroid preparations) ( 31015401 ) Metabolite levels ( 23823483 ) Mild age-related type 2 diabetes ( 34737425 ) Multiple sclerosis ( 24076602 ) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701 ) Psychosis (atypical) ( 24132900 ) Rheumatoid arthritis ( 32723749 24390342 30423114 23143596 30572963 ) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596 ) Systemic lupus erythematosus ( 33272962 28714469 ) Type 1 diabetes ( 25751624 21829393 18840781 ) Type 2 diabetes ( 30718926 30297969 32499647 28254843 22961080 )	Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Body mass index ( 29273807 ) Brain morphology (MOSTest) ( 32665545 ) Crohn's disease ( 21102463 28067908 ) Inflammatory bowel disease ( 28067908 ) Intelligence (MTAG) ( 29326435 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		2 interacting genes: DGKZ HRAS	21 interacting genes: ABL1 BTK CBL CD22 CD79A CD79B CD81 CD82 CD9 CR2 ECT2 FYN GRB2 LYN MAPK1 PIK3R1 PLCG2 SOS1 SYK VAV1 VAV2
Entrez ID		10125	930
HPRD ID		04909	00113
Ensembl ID		ENSG00000172575	ENSG00000177455
Uniprot IDs		B2RA89 O95267	P15391
PDB IDs		4L9M 4L9U	6AL5 7JIC 7URV 7URX
GO Terms Enriched among Interactors		None	Immune Response-activating Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Lymphocyte Activation Immune Response-activating Signaling Pathway Positive Regulation Of Immune Response B Cell Activation Phosphotyrosine Residue Binding Immune Response-regulating Signaling Pathway Activation Of Immune Response Leukocyte Activation Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Immune System Process Immune Effector Process Immune System Process Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Regulation Of Cell Activation Leukocyte Proliferation Positive Regulation Of Intracellular Signal Transduction Regulation Of Lymphocyte Activation B Cell Proliferation Plasma Membrane Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway B Cell Differentiation Lymphocyte Proliferation Mononuclear Cell Differentiation Mononuclear Cell Proliferation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Lymphocyte Activation Ephrin Receptor Binding Immune Response Leukocyte Differentiation Lymphocyte Differentiation Positive Regulation Of Signal Transduction Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of T Cell Activation Cellular Developmental Process Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Defense Response