RASGRP1 and TRIM33

		RASGRP1	TRIM33
Description		RAS guanyl releasing protein 1	tripartite motif containing 33
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane	Chromatin Nucleus Nucleoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Zinc Ion Binding Lipid Binding Diacylglycerol Binding GTPase Regulator Activity Phosphatidylcholine Binding Identical Protein Binding Metal Ion Binding	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Co-SMAD Binding R-SMAD Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Inflammatory Response To Antigenic Stimulus Positive Regulation Of Immune System Process Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Natural Killer Cell Activation Cell Differentiation Secretory Granule Localization Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus T Cell Proliferation B Cell Proliferation T Cell Activation B Cell Activation Mast Cell Degranulation Positive Regulation Of MAP Kinase Activity Leukocyte Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Ras Protein Signal Transduction Vesicle Transport Along Microtubule Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of ERK1 And ERK2 Cascade Activation Of GTPase Activity Regulation Of Intracellular Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of DNA-templated Transcription
Pathways		Effects of PIP2 hydrolysis Activation of RAS in B cells Activation of RAS in B cells FCERI mediated NF-kB activation Integrin signaling Rap1 signalling RAF/MAP kinase cascade	Downregulation of SMAD2/3:SMAD4 transcriptional activity Germ layer formation at gastrulation
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Bipolar disorder ( 18711365) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Crohn's disease ( 23128233 28067908) Estimated glomerular filtration rate ( 30604766) Glucagon levels in response to oral glucose tolerance test (decremental area under the curve for 0-30 minutes) ( 33407418) Medication use (thyroid preparations) ( 31015401) Metabolite levels ( 23823483) Mild age-related type 2 diabetes ( 34737425) Multiple sclerosis ( 24076602) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Psychosis (atypical) ( 24132900) Rheumatoid arthritis ( 32723749 24390342 30423114 23143596 30572963) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Systemic lupus erythematosus ( 33272962 28714469) Type 1 diabetes ( 25751624 21829393 18840781) Type 2 diabetes ( 30718926 30297969 32499647 28254843 22961080)	Autism ( 24189344) Carotid intima media thickness x smoking interaction ( 32117412) Chronotype ( 30696823) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		2 interacting genes: DGKZ HRAS	14 interacting genes: CEBPA CHD1L CTNNB1 E2F4 ERG H3C1 NLGN3 RSPH1 SMAD3 TRIM24 UBE2D2 UBE2D3 UBE2E1 UBE2N
Entrez ID		10125	51592
HPRD ID		04909	10423
Ensembl ID		ENSG00000172575	ENSG00000197323
Uniprot IDs		B2RA89 O95267	B3KN30 Q9UPN9
PDB IDs		4L9M 4L9U	3U5M 3U5N 3U5O 3U5P 5MR8 7ZDD 8BD8 8BD9 8BDY
Enriched GO Terms of Interacting Partners?			Ubiquitin Conjugating Enzyme Activity Chromatin Binding Ubiquitin-protein Transferase Activity Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nuclear Receptor Binding Protein Ubiquitination Nucleoplasm Protein Monoubiquitination Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Protein Modification By Small Protein Conjugation Embryonic Foregut Morphogenesis Transcription Regulator Complex Post-translational Protein Modification Osteoblast Development I-SMAD Binding Positive Regulation Of Macromolecule Metabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Catabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Metabolic Process Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Population Proliferation Positive Regulation Of RNA Biosynthetic Process Nucleus Positive Regulation Of DNA-templated Transcription Cell Population Proliferation Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein-containing Complex Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cell Development Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Striated Muscle Tissue Development Regulation Of Muscle Organ Development
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