PPM1F and KLHL8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PPM1F	KLHL8
Description		protein phosphatase, Mg2+/Mn2+ dependent 1F	kelch like family member 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Protein-containing Complex Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Calmodulin-dependent Protein Phosphatase Activity Cation Binding Metal Ion Binding	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Apoptotic Process Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Cell Migration Regulation Of Protein Localization Intracellular Signal Transduction Negative Regulation Of DNA-templated Transcription Positive Regulation Of Growth Positive Regulation Of Chemotaxis Negative Regulation Of Protein Transport Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Cellular Response To Xenobiotic Stimulus Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Negative regulation of NMDA receptor-mediated neuronal transmission
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Attention deficit hyperactivity disorder ( 18839057) Bipolar disorder ( 31043756)	Alanine aminotransferase levels ( 33547301 33339817) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 29403010 33547301 33339817) Bulimia nervosa ( 23568457) Eyebrow thickness ( 26926045) HDL cholesterol levels ( 28334899) Rosacea symptom severity ( 29771307) Total cholesterol levels ( 30275531) Triglyceride levels ( 28334899 29403010 33339817) Triglycerides ( 20686565 25961943 24097068)
Interacting Genes		21 interacting genes: AATK ARHGEF7 CAMK2A ERBB2 ERBB3 ERBB4 FAM161A FEM1A FEM1B KLHL8 LATS1 LMTK2 MARS1 MEOX1 OGT PAK1 PRKAA1 PTK7 ROR1 ROR2 WEE2-AS1	13 interacting genes: ARMC9 ATXN1 CA8 COIL MAPK9 PNMT PPM1F RAPSN RLBP1 SULT2B1 TEX101 TP53I13 USP7
Entrez ID		9647	57563
HPRD ID		10163	13928
Ensembl ID		ENSG00000100034	ENSG00000145332
Uniprot IDs		B5MCT7 P49593	B3KY78 Q68DU9 Q9P2G9
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Kinase Activity ATP Binding Nucleotide Binding Transferase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Coreceptor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB3:ERBB2 Complex Wound Healing ERBB2 Signaling Pathway Protein Serine Kinase Activity Receptor Complex Neuregulin Receptor Activity Positive Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Protein Modification Process Enzyme-linked Receptor Protein Signaling Pathway ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Response To Epidermal Growth Factor Regulation Of Catalytic Activity Protein Phosphorylation Cell Surface Receptor Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Mesenchyme Development Epidermal Growth Factor Receptor Signaling Pathway Apoptotic Process Glial Cell Development Regulation Of Protein Localization Basal Plasma Membrane Phosphorylation Cell Death Programmed Cell Death Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Regulation Of Insulin Receptor Signaling Pathway Axon Response To Wounding ERBB Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Fibroblast Migration Regulation Of Organ Growth
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