PPM1F and ARHGEF7

Number of citations of the paper that reports this interaction (PMID 11864573)
26

Data Source:
HPRD (in vivo)

		PPM1F	ARHGEF7
Gene Name		protein phosphatase, Mg2+/Mn2+ dependent, 1F	Rho guanine nucleotide exchange factor (GEF) 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Protein Complex Perinuclear Region Of Cytoplasm	Ruffle Cytosol Focal Adhesion Cell Cortex Lamellipodium Neuron Projection Neuronal Cell Body Protein Complex
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cell-substrate Adhesion Histone Dephosphorylation Negative Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Drug Peptidyl-threonine Dephosphorylation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Growth Positive Regulation Of Chemotaxis Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Intrinsic Apoptotic Signaling Pathway	Hematopoietic Progenitor Cell Differentiation Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Fibroblast Migration Lamellipodium Assembly Positive Regulation Of Rac GTPase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Focal Adhesion Assembly Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Lamellipodium Morphogenesis
Pathways			EGFR downregulation Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE Signaling by Ligand-Responsive EGFR Variants in Cancer p75 NTR receptor-mediated signalling Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Rho GTPase cycle Signaling by EGFR GPCR downstream signaling Ephrin signaling NRAGE signals death through JNK Signaling by Rho GTPases Signaling by EGFR in Cancer EPH-Ephrin signaling G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 18839057)	Bilirubin levels ( 19414484) Menarche (age at onset) ( 21102462) Menopause (age at onset) ( 19448619)
Protein-Protein Interactions		8 interactors: ARHGEF7 CAMK2A CAMK2G FAM161A FEM1A FEM1B MARS PAK1	28 interactors: ADAM15 ARHGEF6 CALM1 CBLB CD244 CDC42 ERBB2IP GIT1 GIT2 LRRK2 MEOX2 NCK1 NCKIPSD PAK1 PAK2 PAK3 PPM1E PPM1F PXN RAC1 SCRIB SH2D1A SHANK1 SHANK2 TGFBR2 TUBB3 WAS YWHAG
Entrez ID		9647	8874
HPRD ID		10163	05688
Ensembl ID		ENSG00000100034	ENSG00000102606
Uniprot IDs		B7Z2C3 P49593	B7Z6G2 E9PDQ5 Q14155
PDB IDs			1BY1 1ZSG 2L3G
Enriched GO Terms of Interacting Partners?		Protein Autophosphorylation Regulation Of Cellular Response To Heat Apoptotic Process Programmed Cell Death Cellular Response To Heat Cell Death Death Regulation Of Ubiquitin-protein Transferase Activity Ephrin Receptor Signaling Pathway Response To Heat Methionyl-tRNA Aminoacylation Cellular Protein Metabolic Process Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Lamellipodium Morphogenesis Cellular Response To Interferon-gamma G1/S Transition Of Mitotic Cell Cycle Response To Interferon-gamma Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Epithelial Cell Maturation Involved In Prostate Gland Development Response To Temperature Stimulus Regulation Of Calcium Ion Transport Cellular Protein Modification Process Innate Immune Response Regulation Of Protein Ubiquitination Cellular Response To Organic Substance Cell Projection Morphogenesis Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Lamellipodium Morphogenesis Regulation Of Relaxation Of Cardiac Muscle Histone H3-T11 Phosphorylation Cell Part Morphogenesis Morphogenesis Of A Branching Epithelium Regulation Of Relaxation Of Muscle Protein Metabolic Process Morphogenesis Of A Branching Structure Regulation Of Skeletal Muscle Adaptation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Immune System Process Contact Inhibition Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Fibroblast Migration Cell Projection Assembly Regulation Of DNA Damage Checkpoint Cell Morphogenesis Response To Abiotic Stimulus Calcium Ion Transport Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Catalytic Activity Cell Projection Organization	Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Regulation Of Catalytic Activity Cell Morphogenesis Involved In Differentiation Regulation Of Protein Kinase Activity Regulation Of Signaling Cell Morphogenesis Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Cell Projection Organization Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Phosphorylation Fc Receptor Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Programmed Cell Death Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Death Regulation Of Cell Adhesion Regulation Of T Cell Activation Neuron Projection Morphogenesis Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Organelle Organization Positive Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Cell Development Movement Of Cell Or Subcellular Component Regulation Of Cytoskeleton Organization Positive Regulation Of T Cell Activation Neuron Development Positive Regulation Of Protein Metabolic Process Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Actin Cytoskeleton Organization Nervous System Development Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Immune System Process Positive Regulation Of Transferase Activity Axon Guidance Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Anatomical Structure Morphogenesis Regulation Of Actin Filament-based Process Neuron Projection Development
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