PPM1F and FEM1A

Number of citations of the paper that reports this interaction (PMID 11559703)
13

Data Source:
HPRD (in vivo)

		PPM1F	FEM1A
Gene Name		protein phosphatase, Mg2+/Mn2+ dependent, 1F	fem-1 homolog a (C. elegans)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Protein Complex Perinuclear Region Of Cytoplasm	Cytoplasm
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding	Ubiquitin-protein Transferase Activity EP4 Subtype Prostaglandin E2 Receptor Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cell-substrate Adhesion Histone Dephosphorylation Negative Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Drug Peptidyl-threonine Dephosphorylation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Growth Positive Regulation Of Chemotaxis Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Intrinsic Apoptotic Signaling Pathway	Protein Ubiquitination Negative Regulation Of Inflammatory Response Regulation Of Ubiquitin-protein Transferase Activity
Pathways
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 18839057)
Protein-Protein Interactions		8 interactors: ARHGEF7 CAMK2A CAMK2G FAM161A FEM1A FEM1B MARS PAK1	2 interactors: PPM1F PTGER4
Entrez ID		9647	55527
HPRD ID		10163	16888
Ensembl ID		ENSG00000100034	ENSG00000141965
Uniprot IDs		B7Z2C3 P49593	Q9BSK4
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Autophosphorylation Regulation Of Cellular Response To Heat Apoptotic Process Programmed Cell Death Cellular Response To Heat Cell Death Death Regulation Of Ubiquitin-protein Transferase Activity Ephrin Receptor Signaling Pathway Response To Heat Methionyl-tRNA Aminoacylation Cellular Protein Metabolic Process Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Lamellipodium Morphogenesis Cellular Response To Interferon-gamma G1/S Transition Of Mitotic Cell Cycle Response To Interferon-gamma Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Epithelial Cell Maturation Involved In Prostate Gland Development Response To Temperature Stimulus Regulation Of Calcium Ion Transport Cellular Protein Modification Process Innate Immune Response Regulation Of Protein Ubiquitination Cellular Response To Organic Substance Cell Projection Morphogenesis Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Lamellipodium Morphogenesis Regulation Of Relaxation Of Cardiac Muscle Histone H3-T11 Phosphorylation Cell Part Morphogenesis Morphogenesis Of A Branching Epithelium Regulation Of Relaxation Of Muscle Protein Metabolic Process Morphogenesis Of A Branching Structure Regulation Of Skeletal Muscle Adaptation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Immune System Process Contact Inhibition Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Fibroblast Migration Cell Projection Assembly Regulation Of DNA Damage Checkpoint Cell Morphogenesis Response To Abiotic Stimulus Calcium Ion Transport Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Catalytic Activity Cell Projection Organization	Regulation Of Stress Fiber Assembly Negative Regulation Of Eosinophil Extravasation Negative Regulation Of Integrin Activation Negative Regulation Of Eosinophil Migration Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Histone Dephosphorylation Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Regulation Of Cytoskeleton Organization Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Integrin Activation Peptidyl-threonine Dephosphorylation ERK1 And ERK2 Cascade Regulation Of Organelle Organization Negative Regulation Of Leukocyte Migration Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Negative Regulation Of Peptidyl-serine Phosphorylation T-helper Cell Differentiation Negative Regulation Of Cytokine Secretion CD4-positive, Alpha-beta T Cell Differentiation CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Cell-matrix Adhesion Cellular Response To Drug Regulation Of Cell Junction Assembly Alpha-beta T Cell Differentiation Alpha-beta T Cell Activation T Cell Activation Involved In Immune Response Cellular Response To Mechanical Stimulus Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Epithelial Cell Migration JNK Cascade Positive Regulation Of Cytokine Secretion Positive Regulation Of Inflammatory Response Negative Regulation Of Protein Secretion Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Inflammatory Response Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Stress-activated MAPK Cascade Regulation Of Cell-matrix Adhesion Stress-activated Protein Kinase Signaling Cascade
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