HOXA3 and SOX10

Number of citations of the paper that reports this interaction (PubMedID 16582099)
44

Data Source:
HPRD (two hybrid)

		HOXA3	SOX10
Description		homeobox A3	SRY-box transcription factor 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding HMG Box Domain Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Angiogenesis Blood Vessel Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Animal Organ Morphogenesis Anterior/posterior Pattern Specification Specification Of Animal Organ Position Gene Expression Glossopharyngeal Nerve Morphogenesis Thyroid Gland Development Thymus Development Animal Organ Formation Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development Cartilage Development Parathyroid Gland Development Stem Cell Proliferation Positive Regulation Of Stem Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Neural Crest Cell Migration Morphogenesis Of An Epithelium Positive Regulation Of Neuroblast Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Neuroblast Proliferation Peripheral Nervous System Development Anatomical Structure Morphogenesis Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Gene Expression Oligodendrocyte Development Positive Regulation Of Gliogenesis Central Nervous System Myelination Cell Differentiation Melanocyte Differentiation Positive Regulation Of Myelination Developmental Process Lacrimal Gland Development Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Enteric Nervous System Development Digestive Tract Morphogenesis Developmental Growth Oligodendrocyte Differentiation Stem Cell Differentiation Morphogenesis Of A Branching Epithelium Cellular Response To Progesterone Stimulus Cellular Response To Xenobiotic Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination Regulation of CDH19 Expression and Function Regulation of MITF-M-dependent genes involved in pigmentation Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases			Waardenburg syndrome (WS) 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
GWAS		A body shape index ( 34021172) Chronic venous disease ( 28374850) Diastolic blood pressure ( 27618448) Hypertension ( 27618448 30487518) Lymphocyte count ( 32888494) Mean arterial pressure ( 27618448) Monocyte count ( 27863252 32888494) Pulse pressure ( 30487518) Systolic blood pressure ( 30487518 28135244 27618448) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)	Mean spheric corpuscular volume ( 32888494)
Interacting Genes		10 interacting genes: ALX4 ARPC3 POT1 PWP1 RCHY1 SEC23B SOX10 TERF1 TINF2 ZDHHC17	44 interacting genes: ALX4 C10orf55 CDK6 CEBPA CRX CTNNB1 DAZAP2 DLX5 EGR2 ERG EXOC5 GSK3B HHEX HIVEP1 HNF1B HOXA3 HOXC4 HSF4 JUN MAGED1 MAPK1 MEOX1 NFIC NFIX NMI OLIG2 PAX3 PAX6 POU3F2 POU3F3 POU5F1 POU6F2 PRRX1 PRRX2 RCAN1 RSPH1 SP1 SUMO1 SUMO2 SUMO3 TCF12 TIAM1 UBE2I UTF1
Entrez ID		3200	6663
HPRD ID		00842	03752
Ensembl ID		ENSG00000105997	ENSG00000100146
Uniprot IDs		A4D182 B3KPN8 O43365	P56693
PDB IDs
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process Telomeric Loop Disassembly Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Organization Negative Regulation Of DNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Chromosome, Telomeric Region Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere DNA Metabolic Process Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of DNA Metabolic Process Chromosome Positive Regulation Of Shelterin Complex Assembly Growth Cone Leading Edge Histone H4K20me3 Reader Activity Perforant Pathway To Dendrate Granule Cell Synapse Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Macromolecule Biosynthetic Process Chromosome Organization Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Telomeric D-loop Disassembly	HMG Box Domain Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Sequence-specific DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Cis-regulatory Region Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding System Development Negative Regulation Of RNA Metabolic Process Animal Organ Development Developmental Process Animal Organ Morphogenesis Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Embryonic Organ Morphogenesis Nucleoplasm Ubiquitin Protein Ligase Binding Cell Fate Specification Transcription Coregulator Binding Protein Sumoylation
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