UBA2 and SP100

Number of citations of the paper that reports this interaction (PMID 11792325)
199

Data Source:
BioGRID (enzymatic study)

		UBA2	SP100
Gene Name		ubiquitin-like modifier activating enzyme 2	SP100 nuclear antigen
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol SUMO Activating Enzyme Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm PML Body Mre11 Complex Nuclear Periphery
	Molecular Function	Protein Binding ATP Binding Enzyme Activator Activity Transcription Factor Binding SUMO Activating Enzyme Activity Metal Ion Binding Protein Heterodimerization Activity	DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Kinase Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Chromo Shadow Domain Binding
	Biological Process	Protein Sumoylation SMT3-dependent Protein Catabolic Process Positive Regulation Of Catalytic Activity Post-translational Protein Modification Cellular Protein Metabolic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Telomere Maintenance Chromatin Remodeling Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Endothelial Cell Migration Viral Process Cytokine-mediated Signaling Pathway Response To Retinoic Acid Negative Regulation Of Viral Transcription Response To Cytokine Response To Type I Interferon Response To Interferon-gamma Negative Regulation Of DNA Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Protein Export From Nucleus Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Cellular Component Movement Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Fas Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) Processing and activation of SUMO SUMO is transferred from E1 to E2 (UBE2I, UBC9)	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: BRIX1 ETV4 NEDD8 PARK7 RAD23B RANBP2 SAE1 SERBP1 SP100 SUMO1 SUMO1P1 SUMO2 SUMO3 UBC UBE2I	38 interactors: ACTN2 AMOTL2 ARID3A CASP8AP2 CBX1 CBX3 CBX5 CREM DNMT3A DYRK2 ETS1 GIPC2 HIPK2 L3MBTL3 LZTR1 MX1 MYB NIPBL PHC1 PML RANBP2 RBM39 RTP5 SAE1 SENP1 SNIP1 SUMO1 SUMO2 SUMO3 TERF1 TERF2 TERF2IP TRAF3IP3 TRIM29 UBA2 UBE2I USPL1 ZC2HC1A
Entrez ID		10054	6672
HPRD ID		11658	06844
Ensembl ID		ENSG00000126261	ENSG00000067066
Uniprot IDs		B3KWB9 Q9UBT2	E7EUA7 P23497 Q6ZMK3
PDB IDs		1Y8Q 1Y8R 2PX9 3KYC 3KYD	1H5P
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Protein Modification By Small Protein Conjugation Peptidyl-lysine Modification Regulation Of Protein Catabolic Process Post-translational Protein Modification Peptidyl-amino Acid Modification Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Protein Catabolic Process Cellular Protein Modification Process Regulation Of DNA Binding Protein Catabolic Process Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Metabolic Process Negative Regulation Of Binding Cellular Macromolecule Catabolic Process Cytokine-mediated Signaling Pathway Protein Localization To Nucleus Proteolysis Regulation Of Protein Export From Nucleus Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Protein Ubiquitination Viral Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Cytokine Stimulus Positive Regulation Of Cellular Protein Metabolic Process Catabolic Process Negative Regulation Of DNA Binding Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Organic Substance Proteasomal Protein Catabolic Process Regulation Of Binding Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process	Protein Sumoylation PML Body Organization Regulation Of Metabolic Process Peptidyl-lysine Modification Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Telomere Maintenance Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Telomere Maintenance Post-translational Protein Modification Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Nucleus Organization Regulation Of Transcription, DNA-templated Peptidyl-amino Acid Modification Protein Modification By Small Protein Conjugation Regulation Of Gene Expression Telomere Maintenance Via Telomerase Regulation Of Chromosome Organization Positive Regulation Of Metabolic Process Regulation Of Cellular Process SMT3-dependent Protein Catabolic Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Organelle Organization Positive Regulation Of Proteolysis RNA-dependent DNA Replication Positive Regulation Of Cellular Metabolic Process Telomeric Loop Formation Age-dependent Telomere Shortening Negative Regulation Of Chromosome Organization Chromosome Organization Telomere Maintenance Via Telomere Shortening Protection From Non-homologous End Joining At Telomere Protein Desumoylation Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomere Lengthening Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Protein Catabolic Process Telomere Capping Chromatin Modification Positive Regulation Of Cellular Protein Metabolic Process Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase
Tagcloud ?		16q12 2i abrogates anus aos1 brocks cerevisiae chromocenters conjugating covalently dominantly ears gst heterochromatin inherited localize malformations modifier pin2 polymeric pull sall1 sumo sumoylation tbs thumbs townes ubc9 ube2i	aml1 autoregulatory cdnas cofactor deaf deformed deoxyribonuclease displaced dnase fetus germ immunocytochemistry inductions monkey mtg8 nonhomeodomain nudr oncoprotein prodynorphin proenkephalin rares shifts similarities testicular thymidine transfections transferable ttcg ttcgggnntttccgg
Tagcloud (Difference) ?		16q12 2i abrogates anus aos1 brocks cerevisiae chromocenters conjugating covalently dominantly ears gst heterochromatin inherited localize malformations modifier pin2 polymeric pull sall1 sumo sumoylation tbs thumbs townes ubc9 ube2i	aml1 autoregulatory cdnas cofactor deaf deformed deoxyribonuclease displaced dnase fetus germ immunocytochemistry inductions monkey mtg8 nonhomeodomain nudr oncoprotein prodynorphin proenkephalin rares shifts similarities testicular thymidine transfections transferable ttcg ttcgggnntttccgg
Tagcloud (Intersection) ?