HMBS

Gene Name		hydroxymethylbilane synthase
Image
Gene Ontology Annotations	Cellular Component	Cytosol
	Molecular Function	Hydroxymethylbilane Synthase Activity
	Biological Process	Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Peptidyl-pyrromethane Cofactor Linkage Small Molecule Metabolic Process
Pathways		Heme biosynthesis Metabolism of porphyrins
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: APP RANBP9 ZDHHC17
Entrez ID		3145
HPRD ID		01440
Ensembl ID		ENSG00000256269
Uniprot IDs		P08397
PDB IDs		3ECR 3EQ1
Enriched GO Terms of Interacting Partners?		Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Axon Guidance Neuron Remodeling Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cellular Copper Ion Homeostasis Lipoprotein Transport Magnesium Ion Transport Microtubule Nucleation Cell Morphogenesis Involved In Differentiation Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Microtubule-based Process Microtubule Polymerization Neuron Projection Development Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Palmitoylation Cell Projection Morphogenesis Cell Part Morphogenesis Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Neuron Development Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Microtubule Polymerization Or Depolymerization Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Morphogenesis Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Neuron Differentiation Mating Neuromuscular Junction Development Cell Projection Organization Positive Regulation Of Mitotic Cell Cycle Phase Transition Neuron Apoptotic Process Positive Regulation Of Cell Cycle Phase Transition Regulation Of Protein Tyrosine Kinase Activity
Tagcloud ?		1082dupc ahp ahps aip biosynthetic cancerous catalyzing complication g111r germline hcc hccs heme hit hydroxymethylbilane intermittent l220x l416x oxidase pathomechanisms porphyria porphyrias ppox protoporphyrinogen respective somatic suppressors variegate vp