HMBS and ETS1

Data Source: HiPPIP (Novel)

		HMBS	ETS1
Name		hydroxymethylbilane synthase	ETS proto-oncogene 1, transcription factor
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Hydroxymethylbilane Synthase Activity Protein Binding Transferase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Porphyrin-containing Compound Biosynthetic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Tetrapyrrole Biosynthetic Process Heme O Biosynthetic Process	Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Immune Response Negative Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Cell Differentiation PML Body Organization Regulation Of Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Erythrocyte Differentiation Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Antibiotic Cell Motility Positive Regulation Of Inflammatory Response Positive Regulation Of MiRNA Transcription Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways		Heme biosynthesis	Oncogene Induced Senescence
Diseases		Hepatic porphyria, including: Porphyria Cutanea Tarda (PCT); VHepatoerythropoietic porphyria; Acute Intermittent Porphyria (AIP); Variegate porphyria (VP); ALA-dehydratase deficiency porphyria (ALADP); Hereditary Coproporphyria (HCP)	None
GWAS		Apolipoprotein A1 levels ( 32203549 )	Adverse response to drug ( 30420678 ) Albumin-globulin ratio ( 29403010 ) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Asthma ( 32296059 30929738 ) Asthma (childhood onset) ( 30929738 ) Atopic dermatitis ( 26482879 ) Celiac disease ( 20190752 22057235 25920553 30572963 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Depressive and manic episodes in bipolar disorder ( 26297903 ) Depressive episodes in bipolar disorder ( 26297903 ) Eczema ( 31361310 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Fasting glucose ( 34059833 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Follicular lymphoma ( 25279986 ) Glaucoma ( 31959993 30054594 ) Glaucoma (multi-trait analysis) ( 31959993 ) Glaucoma (primary open-angle) ( 33627673 ) Granulocyte count ( 27863252 ) Height ( 31562340 ) Inflammatory bowel disease ( 28067908 ) Intraocular pressure ( 31959993 30054594 29785010 29617998 ) Itch intensity from mosquito bite ( 28199695 ) Liver fibrosis in pediatric non-alcoholic fatty acid liver disease ( 28918882 ) Lung function (FVC) ( 30061609 ) Lymphocyte count ( 32888494 27863252 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Manganese levels ( 26025379 ) Medication use (thyroid preparations) ( 31015401 ) Monocyte count ( 27863252 32888494 ) Mosquito bite size ( 28199695 ) Multiple sclerosis ( 31604244 24076602 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 32888494 27863252 ) Neutrophil percentage of white cells ( 32888494 ) Non-albumin protein levels ( 29403010 ) Obesity-related traits ( 23251661 ) Platelet count ( 32888494 27863252 ) Plateletcrit ( 27863252 32888494 ) Psoriasis ( 25903422 23143594 ) Psoriasis vulgaris ( 26626624 ) Refractive error ( 32231278 ) Rheumatoid arthritis ( 24390342 30423114 22446963 ) Rheumatoid arthritis (ACPA-positive) ( 24532676 ) Self-reported allergy ( 23817569 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Systemic lupus erythematosus ( 19838193 20169177 23273568 28714469 27399966 26502338 26663301 ) Triglyceride levels in HIV infection ( 33109212 ) Type 2 diabetes ( 30718926 30297969 30054458 ) Ulcerative colitis ( 28067908 ) White blood cell count ( 27863252 32888494 )
Novel Interactors		1 novel interactors: ETS1	8 novel interactors: CBL CFP DPAGT1 EPHA4 HMBS QPRT SLC37A4 SPIRE1
Interacting Genes		5 interacting genes: APP GSK3A PICK1 RANBP9 ZDHHC17	54 interacting genes: APLP2 APP ARID4B ARL6IP4 ATF2 BRCA1 CAMK2A CAMK2B COP1 CREB1 CREBBP CYBC1 DAXX DNMT3L EIF5B EP300 ETS2 FOS GATA3 GGA1 GGA2 GGA3 HTATIP2 JUN MAF MAPK1 MAPK3 MAPK7 MED23 MEIS1 NCL NCOR1 NFKB1 NR3C1 PARP1 PAX5 POU1F1 RBBP6 RPL13A RUNX1T1 RUNX2 SMAD3 SP1 SP100 SPI1 SRA1 SRC SRSF11 STAT5B STAT6 TBP TDP2 UBE2I XRCC6
Entrez ID		3145	2113
HPRD ID		01440	01260
Ensembl ID		ENSG00000256269	ENSG00000134954
Uniprot IDs		A0A3F2YNY7 A0A8I5KXV4 P08397	A8K725 B4DW78 P14921
PDB IDs		3ECR 3EQ1 5M6R 5M7F 7AAJ 7AAK 7CCX 7CCY 7CCZ 7CD0 8PND	1GVJ 2NNY 2STT 2STW 3MFK 3RI4 3WTS 3WTT 3WTU 3WTV 3WTW 3WTX 3WTY 3WTZ 3WU0 3WU1 4L0Y 4L0Z 4L18 4LG0 5ZMC
GO Terms Enriched among Interactors		Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Amyloid Precursor Protein Catabolic Process Signaling Receptor Binding Positive Regulation Of Receptor Internalization Neuron Projection Organization Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Regulation Of Carbohydrate Catabolic Process Regulation Of MiRNA Transcription Amylin Binding Positive Regulation Of Toll Signaling Pathway G Protein-coupled Receptor Binding Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Receptor Internalization Glial Cell Development Negative Regulation Of UDP-glucose Catabolic Process Perforant Pathway To Dendrate Granule Cell Synapse Regulation Of MiRNA Metabolic Process Modulation Of Chemical Synaptic Transmission Acetylcholine Receptor Activator Activity Negative Regulation Of Canonical Wnt Signaling Pathway PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Establishment Of Protein Localization Trans-Golgi Network Membrane Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Signaling Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Regulation Of Programmed Cell Death Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Cell Communication Regulation Of MAPK Cascade Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Presynaptic Membrane Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission	Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Negative Regulation Of Biosynthetic Process Nucleoplasm Chromatin Transcription Regulator Complex Negative Regulation Of Metabolic Process Response To Growth Factor Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Metabolic Process Identical Protein Binding Nucleus Macromolecule Metabolic Process DNA-binding Transcription Factor Activity DNA-templated Transcription Cellular Response To Growth Factor Stimulus Regulation Of MiRNA Transcription Transcription By RNA Polymerase II Transcription Coactivator Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway