TOM1 and DNAL4

		TOM1	DNAL4
Description		target of myb1 membrane trafficking protein	dynein axonemal light chain 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Membrane Early Endosome Membrane Azurophil Granule Membrane Specific Granule Membrane Extracellular Exosome	Cytoplasm Cytoskeleton Microtubule Plasma Membrane Cilium Dynein Complex Cell Projection
	Molecular Function	Protein Binding Phosphatidylinositol-5-phosphate Binding Clathrin Binding Polyubiquitin Modification-dependent Protein Binding Clathrin Heavy Chain Binding Phosphatidylinositol Binding Ubiquitin Binding Myosin VI Binding	Microtubule Motor Activity Protein Binding Identical Protein Binding
	Biological Process	Endocytosis Signal Transduction Protein Transport Endosomal Transport Substrate Localization To Autophagosome Autophagosome-lysosome Fusion Positive Regulation Of Autophagosome Maturation Regulation Of Endosome Organization	Microtubule-based Process Microtubule-based Movement
Pathways		Neutrophil degranulation	Retrograde neurotrophin signalling
Drugs
Diseases
GWAS		Cholesterol, total ( 24097068) HDL cholesterol ( 29404214) High density lipoprotein cholesterol levels ( 31217584) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hippocampal volume in mild cognitive impairment ( 29274321) Inflammatory bowel disease ( 28067908) Low density lipoprotein cholesterol levels ( 32154731) Multiple myeloma ( 26007630) Multiple myeloma and monoclonal gammopathy ( 26007630) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Total cholesterol levels ( 28334899) Triglyceride levels ( 34074324) Ulcerative colitis ( 28067908) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		25 interacting genes: APP BBS4 BBS5 BBS9 CLTC DAZAP2 EEA1 HACL2 LITAF LRRC20 NAA11 NEDD4 OGT PILRA PTBP2 RPS27 SMURF1 SNCA SSBP2 TOLLIP UBC UBE2D1 WWP2 ZFYVE16 ZNF512B	14 interacting genes: CHIC2 DYNLL2 FHL5 GNA14 GPBP1 KRTAP10-3 KRTAP12-3 KRTAP9-8 NFATC2IP NOTCH2NLA NTAQ1 NUDT22 SCTR TRIM54
Entrez ID		10043	10126
HPRD ID		05265	13239
Ensembl ID		ENSG00000100284	ENSG00000100246
Uniprot IDs		B3KUF5 O60784	O96015
PDB IDs		1ELK 1WRD 2N2N 2N9D 6J56
Enriched GO Terms of Interacting Partners?		BBSome Protein-containing Complex Protein Localization To Vacuole Cytoplasm Negative Regulation Of Potassium Ion Export Across Plasma Membrane Protein Localization To Organelle Centriolar Satellite Establishment Of Localization In Cell Protein Targeting To Vacuole Ciliary Membrane Protein Localization To Lysosome Potassium Channel Inhibitor Activity Establishment Of Protein Localization To Vacuole Cytosol Intracellular Protein Localization Protein Transport Receptor Internalization Modification-dependent Protein Catabolic Process Regulation Of Potassium Ion Export Across Plasma Membrane 1-phosphatidylinositol Binding Early Endosome Membrane Intracellular Transport Negative Regulation Of Transcription By RNA Polymerase II Endocytosis Regulation Of Neurotransmitter Uptake Protein Serine/threonine Kinase Binding Cellular Response To Copper Ion Establishment Of Melanosome Localization Pericentriolar Material Melanosome Localization Establishment Of Protein Localization Melanosome Transport Pigment Granule Transport Establishment Of Vesicle Localization Receptor Catabolic Process Negative Regulation Of Potassium Ion Transmembrane Transport Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity WW Domain Binding Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Low-density Lipoprotein Particle Receptor Binding Regulation Of Presynapse Assembly Regulation Of Monoatomic Cation Transmembrane Transport Pigment Granule Localization Negative Regulation Of MiRNA Transcription Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Response To Copper Ion
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