DNAL4 and SCTR

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		DNAL4	SCTR
Description		dynein axonemal light chain 4	secretin receptor
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Microtubule Plasma Membrane Cilium Dynein Complex Cell Projection	Cytoplasmic Microtubule Plasma Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	Microtubule Motor Activity Protein Binding Identical Protein Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Peptide Receptor Activity Secretin Receptor Activity Peptide Hormone Binding
	Biological Process	Microtubule-based Process Microtubule-based Movement	Diet Induced Thermogenesis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Intracellular Water Homeostasis Response To Nutrient Levels Regulation Of Appetite Regulation Of Synaptic Plasticity
Pathways		Retrograde neurotrophin signalling	G alpha (s) signalling events Glucagon-type ligand receptors
Drugs			Secretin human
Diseases
GWAS			Bipolar disorder ( 31043756) Type 2 diabetes ( 30718926 32499647)
Interacting Genes		14 interacting genes: CHIC2 DYNLL2 FHL5 GNA14 GPBP1 KRTAP10-3 KRTAP12-3 KRTAP9-8 NFATC2IP NOTCH2NLA NTAQ1 NUDT22 SCTR TRIM54	9 interacting genes: ADCYAP1 CALM1 CPAMD8 CYFIP1 DNAL4 PRKAR2A PRKCA SCT SNTA1
Entrez ID		10126	6344
HPRD ID		13239	01628
Ensembl ID		ENSG00000100246	ENSG00000080293
Uniprot IDs		O96015	P47872 Q8IV17
PDB IDs			6WI9 6WZG 7D3S
Enriched GO Terms of Interacting Partners?			Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Positive Regulation Of CAMP/PKA Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Hormone Secretion Regulation Of Peptide Hormone Secretion Regulation Of System Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Hormone Secretion G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Secretion Pituitary Adenylate Cyclase Activating Polypeptide Activity Positive Regulation Of Secretion By Cell Protein-containing Complex Positive Regulation Of Somatostatin Secretion Negative Regulation Of Gastrin-induced Gastric Acid Secretion Digestive Hormone Activity Regulation Of Transport Positive Regulation Of Signal Transduction Regulation Of Biological Quality Positive Regulation Of Cell Communication Signaling Receptor Binding Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Positive Regulation Of Signaling Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Positive Regulation Of Pancreatic Juice Secretion Regulation Of Heart Rate Regulation Of Signal Transduction Hormone Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Alphav-beta3 Integrin-PKCalpha Complex Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Protein Kinase C Signaling Negative Regulation Of Gastric Acid Secretion Syntrophin Complex Regulation Of Translation At Postsynapse Regulation Of Hormone Levels Extracellular Region Transmembrane Transporter Binding Regulation Of Secretion By Cell Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane
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