FNDC3A and NUDT15

		FNDC3A	NUDT15
Description		fibronectin type III domain containing 3A	nudix hydrolase 15
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GO Annotations	Cellular Component	Golgi Membrane Acrosomal Vesicle Cytoplasm Golgi Apparatus Cytosol Endomembrane System Vesicle Membrane Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle	Cytosol
	Molecular Function	RNA Binding	Protein Binding 8-oxo-7,8-dihydroguanosine Triphosphate Pyrophosphatase Activity Hydrolase Activity 8-oxo-7,8-dihydrodeoxyguanosine Triphosphate Pyrophosphatase Activity 8-oxo-dGDP Phosphatase Activity Metal Ion Binding Nucleoside Triphosphate Diphosphatase Activity
	Biological Process	Spermatid Development Fertilization Sertoli Cell Development Cell-cell Adhesion	Mitotic Cell Cycle Response To Reactive Oxygen Species Purine Nucleotide Catabolic Process DGTP Catabolic Process Response To Stress Purine Deoxyribonucleoside Triphosphate Catabolic Process Xenobiotic Catabolic Process DNA Protection Nucleobase-containing Small Molecule Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Nucleoside Phosphate Catabolic Process
Pathways			Phosphate bond hydrolysis by NUDT proteins Azathioprine ADME
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol levels ( 32203549) Pelvic organ prolapse ( 26545240) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Trunk fat mass ( 28552196)	Estimated glomerular filtration rate ( 31015462) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 27558924 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)
Interacting Genes		2 interacting genes: APP PDCD6	2 interacting genes: GABARAPL2 SRD5A3
Entrez ID		22862	55270
HPRD ID		13548	14848
Ensembl ID		ENSG00000102531	ENSG00000136159
Uniprot IDs		Q9Y2H6	Q9NV35
PDB IDs		1WK0 1X3D 1X4X 1X5X 2CRM 2CRZ	5BON 5LPG 6T5J 7AOM 7AOP 7B63 7B64 7B65 7B66 7B67 7B7V 7NR6 7R0D
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Protein Monoubiquitination 8-oxo-7,8-dihydroguanosine Triphosphate Pyrophosphatase Activity Purine Deoxyribonucleoside Triphosphate Catabolic Process 8-oxo-dGDP Phosphatase Activity DGTP Metabolic Process DGTP Catabolic Process 8-oxo-7,8-dihydrodeoxyguanosine Triphosphate Pyrophosphatase Activity Deoxyribonucleoside Triphosphate Catabolic Process Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Toll Signaling Pathway Regulation Of Protein Monoubiquitination Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Response To Metal Ion Axon Choice Point Recognition Protein Heterodimerization Activity Nucleoside Triphosphate Diphosphatase Activity DNA Protection Regulation Of Protein Catabolic Process Heparan Sulfate Binding	Protein-containing Complex Disassembly Translation Release Factor Activity, Codon Specific Mitochondrial Translational Termination Polyprenol Reductase Activity 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) Activity 3-oxo-5-alpha-steroid 4-dehydrogenase Activity Polyprenol Catabolic Process Dolichyl Monophosphate Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Polyprenal Reductase Activity DCMP Deaminase Activity Translation Release Factor Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor Androgen Biosynthetic Process DNA Cytosine Deamination Translational Termination Cellular Response To Nitrogen Starvation Importin-alpha Family Protein Binding Cytidine Deaminase Activity DNA Deamination Phosphatidylethanolamine Binding Protein Localization To Endoplasmic Reticulum GABA Receptor Binding Sertoli Cell Development Dolichol-linked Oligosaccharide Biosynthetic Process Positive Regulation Of ATP-dependent Activity
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