SYCE1L and MED10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SYCE1L	MED10
Description		synaptonemal complex central element protein 1 like	mediator complex subunit 10
Image		No pdb structure
GO Annotations	Cellular Component	Synaptonemal Complex Intermediate Filament Cytoskeleton	Ubiquitin Ligase Complex Nucleus Nucleoplasm Mediator Complex Core Mediator Complex
	Molecular Function		Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Synaptonemal Complex Assembly Meiotic Cell Cycle Synaptonemal Complex Organization	Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways			PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		36 interacting genes: ALDH18A1 ANKRD36 ATF5 BFSP2 BOLL C1orf216 C22orf39 CALN1 CCDC146 CCDC196 CCHCR1 CENPP CST1 CYTH4 DPPA3 EPC1 FGA HSF2BP KCNIP2 KIAA1328 LCA5L LNX1 MED10 NOL4 NTAQ1 ODF1 OIP5 PFDN5 SCHIP1 SLC7A8 SMARCD1 SPHKAP SRSF10 TNNI1 TRAPPC13 ZNF526	13 interacting genes: ABI2 ARHGDIG CEBPA ESR1 ESR2 FUCA1 HNF4A KDM4B MOB4 NAP1L1 PEBP1 SYCE1L TRIM45
Entrez ID		100130958	84246
HPRD ID			14680
Ensembl ID		ENSG00000205078	ENSG00000133398
Uniprot IDs		A8MT33	Q9BTT4
PDB IDs			7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?			Nuclear Estrogen Receptor Activity Nuclear Receptor Activity Estrogen Response Element Binding Chromatin Estrogen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Steroid Binding Sequence-specific DNA Binding Chromatin Binding Cellular Response To Estradiol Stimulus Intracellular Receptor Signaling Pathway RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Ornithine Metabolic Process Intracellular Signal Transduction DNA-binding Transcription Factor Activity Response To Vitamin B2 C/EBP Complex Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Alpha-L-fucosidase Activity Zonula Adherens Assembly
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