SYCE1L and KCNIP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SYCE1L	KCNIP2
Description		synaptonemal complex central element protein 1 like	potassium voltage-gated channel interacting protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Synaptonemal Complex Intermediate Filament Cytoskeleton	Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Dendrite Monoatomic Ion Channel Complex Synapse Kv4.2-KChIP2 Channel Complex
	Molecular Function		A-type (transient Outward) Potassium Channel Activity Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Identical Protein Binding Transmembrane Transporter Binding Protein-containing Complex Binding Metal Ion Binding ER Retention Sequence Binding
	Biological Process	Synaptonemal Complex Assembly Meiotic Cell Cycle Synaptonemal Complex Organization	Action Potential Detection Of Calcium Ion Monoatomic Ion Transport Potassium Ion Transport Muscle Contraction Signal Transduction Chemical Synaptic Transmission Regulation Of Heart Contraction Regulation Of Signal Transduction Monoatomic Ion Transmembrane Transport Clustering Of Voltage-gated Potassium Channels Regulation Of Membrane Repolarization Potassium Ion Transmembrane Transport Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Potassium Ion Export Across Plasma Membrane
Pathways			Phase 1 - inactivation of fast Na+ channels
Drugs
Diseases
GWAS		Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Type 2 diabetes (age of onset) ( 28060188)	Raw vegetable consumption ( 32066663)
Interacting Genes		36 interacting genes: ALDH18A1 ANKRD36 ATF5 BFSP2 BOLL C1orf216 C22orf39 CALN1 CCDC146 CCDC196 CCHCR1 CENPP CST1 CYTH4 DPPA3 EPC1 FGA HSF2BP KCNIP2 KIAA1328 LCA5L LNX1 MED10 NOL4 NTAQ1 ODF1 OIP5 PFDN5 SCHIP1 SLC7A8 SMARCD1 SPHKAP SRSF10 TNNI1 TRAPPC13 ZNF526	5 interacting genes: GOLGA7 KCND2 KCND3 KCNIP1 SYCE1L
Entrez ID		100130958	30819
HPRD ID			06880
Ensembl ID		ENSG00000205078	ENSG00000120049
Uniprot IDs		A8MT33	A0A2R8Y6D7 B3KSZ5 Q9NS61
PDB IDs			7UKH 7W6S
Enriched GO Terms of Interacting Partners?			Membrane Repolarization Kv4.3-KChIP1 Channel Complex A-type (transient Outward) Potassium Channel Activity Potassium Channel Activity Voltage-gated Potassium Channel Complex Monoatomic Ion Channel Complex Potassium Ion Transmembrane Transport Potassium Ion Export Across Plasma Membrane Potassium Ion Transport Regulation Of Heart Contraction Muscle Contraction Regulation Of Blood Circulation Muscle System Process Postsynaptic Specialization Membrane Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling Voltage-gated Potassium Channel Activity Export Across Plasma Membrane Regulation Of Membrane Potential Dendrite Regulation Of System Process GABA-ergic Synapse Cell-cell Signaling Action Potential Metal Ion Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Signaling Cell Communication Kv4.2-KChIP2 Channel Complex Inorganic Ion Transmembrane Transport Dendritic Spine Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Palmitoyltransferase Complex Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Protein Homooligomerization Monoatomic Ion Transport Postsynaptic Membrane Protein Complex Oligomerization Regulation Of Biological Quality Transmembrane Transport Peptidyl-L-cysteine S-palmitoylation Locomotor Rhythm Cell Projection Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Ventricular Cardiac Muscle Cell Membrane Repolarization
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