ZBTB42 and UBASH3A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZBTB42	UBASH3A
Description		zinc finger and BTB domain containing 42	ubiquitin associated and SH3 domain containing A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Extracellular Exosome
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Muscle Organ Development	Regulation Of Cytokine Production Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		HDL cholesterol ( 24097068 25961943) HDL cholesterol levels ( 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	Addison's disease ( 33574239) Asthma ( 32296059) Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 22057235 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Diverticular disease ( 30177863) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte count ( 32888494) Medication use (thyroid preparations) ( 31015401) Primary sclerosing cholangitis ( 27992413) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Type 1 diabetes ( 18840781 30572963 25751624 21829393 19430480) Vitiligo ( 27723757 20410501)
Interacting Genes		49 interacting genes: AIRIM ANKS1A ASB6 ATG9A BLK CABP5 CATSPER1 CCDC102B CDR2L CIDEC CINP CLIC3 CRY2 FMR1 GEM GOLGA2 GUCD1 HSD3B7 HSF2BP KANK2 KCTD9 KRT40 MAGOHB MAPK1 MDFI MID2 MKRN3 MYLIP NCK2 NDOR1 NOC4L OAZ3 OSGIN1 OSTF1 OTX1 PIN1 PLA2G6 POLR1C RAD51D SNX18 SPG21 TRAPPC2L TRIM68 TTC23 UBASH3A USHBP1 ZBTB16 ZBTB7B ZNF330	105 interacting genes: ARRDC1 ARRDC3 ATF6 BCAR3 CBLB CBS CCDC33 CD3E COPS9 CUEDC1 CXXC5 DAZAP2 DDIT4L DISC1 DLG1 DLGAP4 DNM2 DTX3 EHMT2 FADS6 FAM83A FGFR1OP2 GFAP GOLGA6L9 HSP90AA1 HSP90B1 HSPD1 IKBKG ISY1-RAB43 KCNE1 KCTD1 KIAA0408 KPRP KRT14 KRT31 KRT32 KRT35 KRT39 KRT40 LCN2 LNX1 LZTS1 LZTS2 MAP3K7 MKRN1 MTIF2 N4BP3 NEUROD2 NSMF PDE7A PFDN2 PLEKHB2 PMEPA1 PNMA5 PRDM6 PRKN PSMC1 PSMC4 REL RNF216 RNF41 SF3B4 SH3RF1 SHISA6 SLA2 SLC4A3 SNRNP48 SOS1 SOS2 SPMIP6 SPRY1 SPRY2 SPRYD7 STX11 TAOK1 TAX1BP1 TEKT1 TEKT4 TIMM44 TMCO2 TMEM239 TP53BP2 TP63 TRIM27 TRIM37 TRIM5 TRIM50 TRIM8 TUBB8 UBB UBC UBE2L3 VCP VPS37B VPS72 WAS WASL WBP11 YPEL3 ZBTB42 ZC2HC1C ZIC3 ZNF219 ZNF474 ZRANB1
Entrez ID		100128927	53347
HPRD ID		19441	06904
Ensembl ID		ENSG00000179627	ENSG00000160185
Uniprot IDs		B2RXF5	P57075
PDB IDs			2CRN 5WDI
Enriched GO Terms of Interacting Partners?		Protein Binding	Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Inclusion Body Assembly Post-translational Protein Modification Ubiquitin Protein Ligase Activity Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Identical Protein Binding Aggresome Assembly Proteolysis Involved In Protein Catabolic Process Morphogenesis Of An Epithelium Positive Regulation Of Catabolic Process Sperm Plasma Membrane WW Domain Binding Protein Binding Regulation Of Post-translational Protein Modification Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Keratin Filament Canonical NF-kappaB Signal Transduction Negative Regulation Of Membrane Tubulation Cytosol Cytoskeleton Organization Tissue Morphogenesis Positive Regulation Of Protein Catabolic Process Organelle Organization Modification-dependent Protein Catabolic Process Intermediate Filament Protein Polyubiquitination Macromolecule Catabolic Process Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Regulation Of Intracellular Signal Transduction SH3 Domain Binding P53 Binding Protein Localization To Mitochondrion Linear Polyubiquitin Binding Regulation Of Protein Catabolic Process Protein Polymerization Regulation Of Autophagy Regulation Of Signal Transduction Suppression Of Viral Release By Host Positive Regulation Of Protein Metabolic Process Regulation Of Type I Interferon Production Positive Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity
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