ATP6V1A and GCH1

		ATP6V1A	GCH1
Description		ATPase H+ transporting V1 subunit A	GTP cyclohydrolase 1
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GO Annotations	Cellular Component	Vacuolar Proton-transporting V-type ATPase, V1 Domain Nucleoplasm Lysosomal Membrane Cytosol Plasma Membrane Microvillus Apical Plasma Membrane Proton-transporting Two-sector ATPase Complex Transport Vesicle Secretory Granule Intracellular Membrane-bounded Organelle Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Neuron Projection Terminus
	Molecular Function	Protein Binding ATP Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism	GTPase Activity GTP Cyclohydrolase I Activity Calcium Ion Binding Protein Binding GTP Binding Zinc Ion Binding GTP-dependent Protein Binding Translation Initiation Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Cellular Iron Ion Homeostasis ATP Synthesis Coupled Proton Transport Regulation Of Macroautophagy Cellular Response To Increased Oxygen Levels Proton Transmembrane Transport	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Heart Rate Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Interferon-gamma Response To Tumor Necrosis Factor 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Vasodilation Dopamine Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Negative Regulation Of Blood Pressure Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Protein-containing Complex Assembly Regulation Of Removal Of Superoxide Radicals
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs		Alendronic acid Etidronic acid Tiludronic acid Bafilomycin A1 Bafilomycin B1	Guanine
Diseases
GWAS		Prostate cancer ( 23535732)	Chronotype ( 30696823) Mercury levels ( 26025379) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 32201043 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 22446963) Serum metabolite levels ( 33031748)
Interacting Genes		15 interacting genes: ANXA7 CD200R1L CDC42 CDKN1A GCH1 GON4L KCNJ9 LPGAT1 LSAMP PPM1D RALGAPA1 SMN1 TK1 TMPRSS7 TUFM	25 interacting genes: AHSA1 ATP1B1 ATP6V1A BDH1 CDC37 CHMP4A CNRIP1 GCHFR GIT2 GPATCH2L HNRNPA1 HSPA8 MPPED2 OAZ1 RAB26 RER1 RLF RND3 RPH3A SH3GL2 SP3 TNIP2 TNPO2 TNPO3 YWHAZ
Entrez ID		523	2643
HPRD ID		06120	02573
Ensembl ID		ENSG00000114573	ENSG00000131979
Uniprot IDs		P38606	A0A024R642 P30793 Q8IZH9
PDB IDs		6WLZ 6WM2 6WM3 6WM4	1FB1 6Z80 6Z85 6Z86 6Z87 6Z88 6Z89
Enriched GO Terms of Interacting Partners?
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