GCH1 and ATP6V1A

		GCH1	ATP6V1A
Description		GTP cyclohydrolase 1	ATPase H+ transporting V1 subunit A
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Neuron Projection Terminus	Vacuolar Proton-transporting V-type ATPase, V1 Domain Nucleoplasm Lysosomal Membrane Cytosol Plasma Membrane Microvillus Apical Plasma Membrane Proton-transporting Two-sector ATPase Complex Transport Vesicle Secretory Granule Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	GTPase Activity GTP Cyclohydrolase I Activity Calcium Ion Binding Protein Binding GTP Binding Zinc Ion Binding GTP-dependent Protein Binding Translation Initiation Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Mitogen-activated Protein Kinase Binding	Protein Binding ATP Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Heart Rate Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Interferon-gamma Response To Tumor Necrosis Factor 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Vasodilation Dopamine Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Negative Regulation Of Blood Pressure Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Protein-containing Complex Assembly Regulation Of Removal Of Superoxide Radicals	Cellular Iron Ion Homeostasis ATP Synthesis Coupled Proton Transport Regulation Of Macroautophagy Cellular Response To Increased Oxygen Levels Proton Transmembrane Transport
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs		Guanine	Alendronic acid Etidronic acid Tiludronic acid Bafilomycin A1 Bafilomycin B1
Diseases
GWAS		Chronotype ( 30696823) Mercury levels ( 26025379) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 32201043 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 22446963) Serum metabolite levels ( 33031748)	Prostate cancer ( 23535732)
Interacting Genes		25 interacting genes: AHSA1 ATP1B1 ATP6V1A BDH1 CDC37 CHMP4A CNRIP1 GCHFR GIT2 GPATCH2L HNRNPA1 HSPA8 MPPED2 OAZ1 RAB26 RER1 RLF RND3 RPH3A SH3GL2 SP3 TNIP2 TNPO2 TNPO3 YWHAZ	15 interacting genes: ANXA7 CD200R1L CDC42 CDKN1A GCH1 GON4L KCNJ9 LPGAT1 LSAMP PPM1D RALGAPA1 SMN1 TK1 TMPRSS7 TUFM
Entrez ID		2643	523
HPRD ID		02573	06120
Ensembl ID		ENSG00000131979	ENSG00000114573
Uniprot IDs		A0A024R642 P30793 Q8IZH9	P38606
PDB IDs		1FB1 6Z80 6Z85 6Z86 6Z87 6Z88 6Z89	6WLZ 6WM2 6WM3 6WM4
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?