GCH1 and GPATCH2L

		GCH1	GPATCH2L
Description		GTP cyclohydrolase 1	G-patch domain containing 2 like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Neuron Projection Terminus
	Molecular Function	GTPase Activity GTP Cyclohydrolase I Activity Calcium Ion Binding Protein Binding GTP Binding Zinc Ion Binding GTP-dependent Protein Binding Translation Initiation Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Mitogen-activated Protein Kinase Binding	Protein Binding
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Heart Rate Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Interferon-gamma Response To Tumor Necrosis Factor 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Vasodilation Dopamine Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Negative Regulation Of Blood Pressure Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Protein-containing Complex Assembly Regulation Of Removal Of Superoxide Radicals
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs		Guanine
Diseases
GWAS		Chronotype ( 30696823) Mercury levels ( 26025379) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 32201043 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 22446963) Serum metabolite levels ( 33031748)	Declining hemoglobin trajectory in blood donors ( 33491795) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Red blood cell count ( 32888494)
Interacting Genes		25 interacting genes: AHSA1 ATP1B1 ATP6V1A BDH1 CDC37 CHMP4A CNRIP1 GCHFR GIT2 GPATCH2L HNRNPA1 HSPA8 MPPED2 OAZ1 RAB26 RER1 RLF RND3 RPH3A SH3GL2 SP3 TNIP2 TNPO2 TNPO3 YWHAZ	48 interacting genes: APP BATF3 CARD10 CCDC33 CEP70 CSNK2A1 CYSRT1 DIP2A GCH1 HSF2BP KDM1A KRT40 KRTAP10-9 KRTAP4-12 LMO1 LMO3 LZTS2 MAB21L3 MDFI MEOX2 NAA10 NDUFB7 PDLIM7 PLAGL2 PNMA2 PRDM14 PRMT1 PRMT8 PSME3 RBM11 RBPMS SUV39H1 THAP1 TLE5 TRIB3 TRIM41 TSPYL1 TULP3 ZBTB48 ZBTB8A ZNF165 ZNF263 ZNF398 ZNF408 ZNF473 ZNF526 ZNF547 ZNF837
Entrez ID		2643	55668
HPRD ID		02573	16594
Ensembl ID		ENSG00000131979	ENSG00000089916
Uniprot IDs		A0A024R642 P30793 Q8IZH9	A0A024R6E4 A0A024R6J0 Q9NWQ4
PDB IDs		1FB1 6Z80 6Z85 6Z86 6Z87 6Z88 6Z89
Enriched GO Terms of Interacting Partners?
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