GCH1 and TNPO2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GCH1	TNPO2
Description		GTP cyclohydrolase 1	transportin 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Neuron Projection Terminus	Nucleus Cytoplasm
	Molecular Function	GTPase Activity GTP Cyclohydrolase I Activity Calcium Ion Binding Protein Binding GTP Binding Zinc Ion Binding GTP-dependent Protein Binding Translation Initiation Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Mitogen-activated Protein Kinase Binding	Protein Binding Nuclear Localization Sequence Binding Small GTPase Binding Nuclear Import Signal Receptor Activity
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Heart Rate Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Interferon-gamma Response To Tumor Necrosis Factor 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Vasodilation Dopamine Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Negative Regulation Of Blood Pressure Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Protein-containing Complex Assembly Regulation Of Removal Of Superoxide Radicals	Protein Import Into Nucleus
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs		Guanine
Diseases
GWAS		Chronotype ( 30696823) Mercury levels ( 26025379) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 32201043 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 22446963) Serum metabolite levels ( 33031748)	Diffuse large B-cell lymphoma or multiple sclerosis ( 31407831)
Interacting Genes		25 interacting genes: AHSA1 ATP1B1 ATP6V1A BDH1 CDC37 CHMP4A CNRIP1 GCHFR GIT2 GPATCH2L HNRNPA1 HSPA8 MPPED2 OAZ1 RAB26 RER1 RLF RND3 RPH3A SH3GL2 SP3 TNIP2 TNPO2 TNPO3 YWHAZ	53 interacting genes: A1CF APIP BEND7 BIRC7 BIRC8 BLMH C12orf40 C1orf94 CAMK2B CAMK2D CAMK2G CCDC158 CRYAB CTAG1A CTAG1B ELAVL1 EXOC5 FH FTO FUCA2 GCH1 GSC2 KLHL2 KLHL20 KLHL3 KRT75 KRTAP8-1 NME1 NUP98 NXF1 OTX2 PACSIN3 PDLIM7 PIK3CD PINX1 PNMA5 POU6F2 PRMT8 PYCR1 RAN RBM45 RPL4 RPRD1B SERTAD3 SF1 TBX2 TCL1B TERF1 THAP6 TRIM8 TRMT1 ZBTB32 ZC2HC1C
Entrez ID		2643	30000
HPRD ID		02573	04301
Ensembl ID		ENSG00000131979	ENSG00000105576
Uniprot IDs		A0A024R642 P30793 Q8IZH9	A0A024R7F7 O14787 Q05D48 Q4LE60
PDB IDs		1FB1 6Z80 6Z85 6Z86 6Z87 6Z88 6Z89
Enriched GO Terms of Interacting Partners?
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