ATP6V1A and PPM1D

		ATP6V1A	PPM1D
Description		ATPase H+ transporting V1 subunit A	protein phosphatase, Mg2+/Mn2+ dependent 1D
Image			No pdb structure
GO Annotations	Cellular Component	Vacuolar Proton-transporting V-type ATPase, V1 Domain Nucleoplasm Lysosomal Membrane Cytosol Plasma Membrane Microvillus Apical Plasma Membrane Proton-transporting Two-sector ATPase Complex Transport Vesicle Secretory Granule Intracellular Membrane-bounded Organelle Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	Protein Binding ATP Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism	Protein Serine/threonine Kinase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Cellular Iron Ion Homeostasis ATP Synthesis Coupled Proton Transport Regulation Of Macroautophagy Cellular Response To Increased Oxygen Levels Proton Transmembrane Transport	G2/M Transition Of Mitotic Cell Cycle DNA Methylation Protein Phosphorylation Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Response To Radiation Response To Bacterium DNA Damage Response, Signal Transduction By P53 Class Mediator Peptidyl-threonine Dephosphorylation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport	Transcriptional regulation by RUNX2
Drugs		Alendronic acid Etidronic acid Tiludronic acid Bafilomycin A1 Bafilomycin B1
Diseases
GWAS		Prostate cancer ( 23535732)	Blood urea nitrogen levels ( 31152163)
Interacting Genes		15 interacting genes: ANXA7 CD200R1L CDC42 CDKN1A GCH1 GON4L KCNJ9 LPGAT1 LSAMP PPM1D RALGAPA1 SMN1 TK1 TMPRSS7 TUFM	25 interacting genes: ATP6V1A BEX2 CASZ1 CHEK2 DIRAS3 DKK3 EPSTI1 ERRFI1 GLCE H3-3A H3C1 ITIH5 KDM1A LYPD3 MAPK11 MDM2 MRC2 NAT2 NCL NSD3 OSGIN1 RHOBTB2 RPL5 TP53 UBC
Entrez ID		523	8493
HPRD ID		06120	05482
Ensembl ID		ENSG00000114573	ENSG00000170836
Uniprot IDs		P38606	A0A0S2Z4M2 O15297
PDB IDs		6WLZ 6WM2 6WM3 6WM4
Enriched GO Terms of Interacting Partners?
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