PLEKHG4 and SMG9

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PLEKHG4	SMG9
Description		pleckstrin homology and RhoGEF domain containing G4	SMG9 nonsense mediated mRNA decay factor
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Eye Development In Utero Embryonic Development Brain Development Heart Development
Pathways		RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Blood protein levels ( 29875488 28240269) Body shape index ( 34021172) Heel bone mineral density ( 28869591) High density lipoprotein cholesterol levels ( 33339817) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)	Lymphocyte counts ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 29403010)
Interacting Genes		66 interacting genes: A1CF ARHGEF5 ARMC7 BEX2 CCDC120 CCDC187 CDC42 CDKN2C CHIC2 COIL DCUN1D5 DPPA3 DTX2 DUSP13 FAM161A FGD2 GATA3 GCM2 GSTZ1 HCK HOXB9 HOXC8 KRT3 KRT75 MALSU1 MATR3 MDFI METAP1 MSRB3 MTA1 MYEF2 MYOZ1 NATD1 OTX1 PFKFB1 PKP2 PLA2G15 PPP1R32 PRPF18 PRPF31 PSMB1 RHOA RIN1 SAXO1 SETD5 SH2D4A SHISA6 SIX1 SMCP SMG9 TBC1D22B TBX18 TEKT3 TENT5D TFAP2D TFG TRIM55 TRIM63 TSSK3 TTC23 USP2 VPS37C ZCCHC14 ZNF148 ZNF319 ZNF648	39 interacting genes: AGTRAP AK8 ARFIP2 CCDC57 CEP76 CMTM4 CTAG1A CTAG1B DGAT2L6 FNTB GOLGA2 GSG1 HSF2BP INCA1 KRT31 KRT34 KRTAP10-8 MTUS2 NFKBID PFDN5 PHF1 PLEKHG4 PNMA3 PPP2R3C PRKAR1B RASSF10 REL SLC17A9 SLC50A1 SYP TCF4 TRAF2 TRIM23 TRIM27 TRIP6 TSC1 TTC19 ZMYND12 ZNF655
Entrez ID		25894	56006
HPRD ID		10890	07800
Ensembl ID		ENSG00000196155	ENSG00000105771
Uniprot IDs		A0A024R6X4 Q58EX7	A0A024R0Q0 Q9H0W8
PDB IDs			6L54 6SYT 6Z3R
Enriched GO Terms of Interacting Partners?
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