SMG9 and AK8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SMG9	AK8
Description		SMG9 nonsense mediated mRNA decay factor	adenylate kinase 8
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Cytoplasm Cytosol Axoneme Sperm Flagellum 9+2 Motile Cilium
	Molecular Function	Protein Binding Identical Protein Binding	Adenylate Kinase Activity Cytidylate Kinase Activity Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding AMP Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Eye Development In Utero Embryonic Development Brain Development Heart Development	Nucleoside Diphosphate Phosphorylation Nucleoside Triphosphate Biosynthetic Process Ventricular System Development Nucleoside Monophosphate Phosphorylation
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Interconversion of nucleotide di- and triphosphates
Drugs			Bis(Adenosine)-5'-Pentaphosphate
Diseases
GWAS		Lymphocyte counts ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 29403010)	Obesity-related traits ( 23251661)
Interacting Genes		39 interacting genes: AGTRAP AK8 ARFIP2 CCDC57 CEP76 CMTM4 CTAG1A CTAG1B DGAT2L6 FNTB GOLGA2 GSG1 HSF2BP INCA1 KRT31 KRT34 KRTAP10-8 MTUS2 NFKBID PFDN5 PHF1 PLEKHG4 PNMA3 PPP2R3C PRKAR1B RASSF10 REL SLC17A9 SLC50A1 SYP TCF4 TRAF2 TRIM23 TRIM27 TRIP6 TSC1 TTC19 ZMYND12 ZNF655	17 interacting genes: ALKBH3 CCDC102B CDK18 CNTF DPY30 FBXO7 HAUS1 MAP3K7CL MCM7 MID1IP1 PRMT6 PRRC2B RBM39 SMG9 SYT17 UBE2Z ZMAT2
Entrez ID		56006	158067
HPRD ID		07800	12991
Ensembl ID		ENSG00000105771	ENSG00000165695
Uniprot IDs		A0A024R0Q0 Q9H0W8	Q96MA6
PDB IDs		6L54 6SYT 6Z3R
Enriched GO Terms of Interacting Partners?
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