PLEKHG4 and DUSP13

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PLEKHG4	DUSP13
Description		pleckstrin homology and RhoGEF domain containing G4	dual specificity phosphatase 13
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatase Activity MAP Kinase Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	Protein Dephosphorylation Spermatogenesis Dephosphorylation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of MAPK Cascade Meiotic Cell Cycle
Pathways		RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Blood protein levels ( 29875488 28240269) Body shape index ( 34021172) Heel bone mineral density ( 28869591) High density lipoprotein cholesterol levels ( 33339817) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)	Blood protein levels ( 30072576 29875488) Body mass index ( 29273807) HDL cholesterol levels ( 32203549) Height ( 31562340)
Interacting Genes		66 interacting genes: A1CF ARHGEF5 ARMC7 BEX2 CCDC120 CCDC187 CDC42 CDKN2C CHIC2 COIL DCUN1D5 DPPA3 DTX2 DUSP13 FAM161A FGD2 GATA3 GCM2 GSTZ1 HCK HOXB9 HOXC8 KRT3 KRT75 MALSU1 MATR3 MDFI METAP1 MSRB3 MTA1 MYEF2 MYOZ1 NATD1 OTX1 PFKFB1 PKP2 PLA2G15 PPP1R32 PRPF18 PRPF31 PSMB1 RHOA RIN1 SAXO1 SETD5 SH2D4A SHISA6 SIX1 SMCP SMG9 TBC1D22B TBX18 TEKT3 TENT5D TFAP2D TFG TRIM55 TRIM63 TSSK3 TTC23 USP2 VPS37C ZCCHC14 ZNF148 ZNF319 ZNF648	15 interacting genes: ACVR1 CALCOCO1 CARD9 CCDC85B CLU HOOK2 HSF2BP INCA1 LMNA PLEKHG4 SH2B2 SMURF1 TGFBR1 TRAF1 ZRANB1
Entrez ID		25894	51207
HPRD ID		10890	13251
Ensembl ID		ENSG00000196155	ENSG00000079393
Uniprot IDs		A0A024R6X4 Q58EX7	Q6B8I1 Q9UII6
PDB IDs			2GWO 2PQ5 5XJV
Enriched GO Terms of Interacting Partners?
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