PLEKHG4 and FGD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PLEKHG4	FGD2
Description		pleckstrin homology and RhoGEF domain containing G4	FYVE, RhoGEF and PH domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol	Ruffle Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Lamellipodium Early Endosome Membrane Ruffle Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding Metal Ion Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	Cytoskeleton Organization Regulation Of Cell Shape Actin Cytoskeleton Organization Regulation Of GTPase Activity Positive Regulation Of JUN Kinase Activity Filopodium Assembly Regulation Of Small GTPase Mediated Signal Transduction
Pathways		RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle	NRAGE signals death through JNK G alpha (12/13) signalling events CDC42 GTPase cycle
Drugs
Diseases
GWAS		Blood protein levels ( 29875488 28240269) Body shape index ( 34021172) Heel bone mineral density ( 28869591) High density lipoprotein cholesterol levels ( 33339817) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)	Acne (severe) ( 24927181) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Rosacea symptom severity ( 29771307)
Interacting Genes		66 interacting genes: A1CF ARHGEF5 ARMC7 BEX2 CCDC120 CCDC187 CDC42 CDKN2C CHIC2 COIL DCUN1D5 DPPA3 DTX2 DUSP13 FAM161A FGD2 GATA3 GCM2 GSTZ1 HCK HOXB9 HOXC8 KRT3 KRT75 MALSU1 MATR3 MDFI METAP1 MSRB3 MTA1 MYEF2 MYOZ1 NATD1 OTX1 PFKFB1 PKP2 PLA2G15 PPP1R32 PRPF18 PRPF31 PSMB1 RHOA RIN1 SAXO1 SETD5 SH2D4A SHISA6 SIX1 SMCP SMG9 TBC1D22B TBX18 TEKT3 TENT5D TFAP2D TFG TRIM55 TRIM63 TSSK3 TTC23 USP2 VPS37C ZCCHC14 ZNF148 ZNF319 ZNF648	5 interacting genes: CDC42 KLHL12 PLEKHG4 RPRM TMEM239
Entrez ID		25894	221472
HPRD ID		10890	05478
Ensembl ID		ENSG00000196155	ENSG00000146192
Uniprot IDs		A0A024R6X4 Q58EX7	Q7Z6J4
PDB IDs
Enriched GO Terms of Interacting Partners?
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