PLEKHG4 and TBX18

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PLEKHG4	TBX18
Description		pleckstrin homology and RhoGEF domain containing G4	T-box transcription factor 18
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol	Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Repressor Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Protein Homodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Somitogenesis Sinoatrial Node Development Regulation Of Transcription By RNA Polymerase II Morphogenesis Of Embryonic Epithelium Smooth Muscle Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Sinoatrial Node Cell Fate Commitment Sinoatrial Node Cell Development Ureter Development Cochlea Morphogenesis Regulation Of SA Node Cell Action Potential
Pathways		RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Blood protein levels ( 29875488 28240269) Body shape index ( 34021172) Heel bone mineral density ( 28869591) High density lipoprotein cholesterol levels ( 33339817) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)	Diabetic retinopathy in type 2 diabetes ( 25364816) Lung function ( 31902109) Monobrow ( 27182965) Pulse pressure ( 30224653) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		66 interacting genes: A1CF ARHGEF5 ARMC7 BEX2 CCDC120 CCDC187 CDC42 CDKN2C CHIC2 COIL DCUN1D5 DPPA3 DTX2 DUSP13 FAM161A FGD2 GATA3 GCM2 GSTZ1 HCK HOXB9 HOXC8 KRT3 KRT75 MALSU1 MATR3 MDFI METAP1 MSRB3 MTA1 MYEF2 MYOZ1 NATD1 OTX1 PFKFB1 PKP2 PLA2G15 PPP1R32 PRPF18 PRPF31 PSMB1 RHOA RIN1 SAXO1 SETD5 SH2D4A SHISA6 SIX1 SMCP SMG9 TBC1D22B TBX18 TEKT3 TENT5D TFAP2D TFG TRIM55 TRIM63 TSSK3 TTC23 USP2 VPS37C ZCCHC14 ZNF148 ZNF319 ZNF648	4 interacting genes: ARC KRTAP8-1 PLEKHG4 TRAF1
Entrez ID		25894	9096
HPRD ID		10890	19076
Ensembl ID		ENSG00000196155	ENSG00000112837
Uniprot IDs		A0A024R6X4 Q58EX7	O95935
PDB IDs
Enriched GO Terms of Interacting Partners?
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