Diabetes - New-wiki

Novel	Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
Novel Novel	Symbols BNIP3 and HPN	Name 1 BCL2 interacting protein 3	Name2 hepsin	Pathway 1	Pathway 2 MET Receptor Activation Signaling by MST1	Drugs 1	Drugs 2 Bentiromide Benzylsulfonic acid CRA_1144 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine	Diseases 1	Diseases 2
Novel Novel	Symbols DPEP1 and KIFBP	Name 1 dipeptidase 1	Name2 kinesin family binding protein	Pathway 1 Synthesis of Leukotrienes (LT) and Eoxins (EX) Aflatoxin activation and detoxification LTC4-CYSLTR mediated IL4 production	Pathway 2	Drugs 1 Cilastatin	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols ELAVL4 and GAP43	Name 1 ELAV like RNA binding protein 4	Name2 growth associated protein 43	Pathway 1	Pathway 2 L1CAM interactions	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols ZBTB5 and JADE2	Name 1 zinc finger and BTB domain containing 5	Name2 jade family PHD finger 2	Pathway 1	Pathway 2 HATs acetylate histones	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CRYBA2 and CALCOCO1	Name 1 crystallin beta A2	Name2 calcium binding and coiled-coil domain 1	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols UBE2D3 and MAEA	Name 1 ubiquitin conjugating enzyme E2 D3	Name2 macrophage erythroblast attacher, E3 ubiquitin ligase	Pathway 1 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TICAM1, RIP1-mediated IKK complex recruitment Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity PINK1-PRKN Mediated Mitophagy Regulation of TNFR1 signaling E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Pathway 2 Regulation of pyruvate metabolism	Drugs 1	Drugs 2 Tetrachlorodecaoxide	Diseases 1	Diseases 2
Novel Novel	Symbols HSPA13 and ST18	Name 1 heat shock protein family A (Hsp70) member 13	Name2 ST18 C2H2C-type zinc finger transcription factor	Pathway 1 Regulation of HSF1-mediated heat shock response	Pathway 2	Drugs 1 Copper	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols HSPA13 and FRY	Name 1 heat shock protein family A (Hsp70) member 13	Name2 FRY microtubule binding protein	Pathway 1 Regulation of HSF1-mediated heat shock response	Pathway 2	Drugs 1 Copper	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CEP70 and ZNF860	Name 1 centrosomal protein 70	Name2 zinc finger protein 860	Pathway 1 Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Pathway 2 Generic Transcription Pathway	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols IRF4 and TRAF2	Name 1 interferon regulatory factor 4	Name2 TNF receptor associated factor 2	Pathway 1 Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Interferon alpha/beta signaling Nuclear events stimulated by ALK signaling in cancer Regulation of MITF-M-dependent genes involved in pigmentation	Pathway 2 Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases Dimerization of procaspase-8 TNF signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation Defective RIPK1-mediated regulated necrosis Regulation of NF-kappa B signaling	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols MTHFS and TSC22D4	Name 1 methenyltetrahydrofolate synthetase	Name2 TSC22 domain family member 4	Pathway 1 Metabolism of folate and pterines	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols AGT and AGTR1	Name 1 angiotensinogen	Name2 angiotensin II receptor type 1	Pathway 1 PPARA activates gene expression Metabolism of Angiotensinogen to Angiotensins Metabolism of Angiotensinogen to Angiotensins Peptide ligand-binding receptors Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events	Pathway 2 Peptide ligand-binding receptors G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Drugs 1 Zinc Copper Sparsentan Zinc acetate	Drugs 2 Valsartan Olmesartan Losartan Candesartan cilexetil Eprosartan Telmisartan Irbesartan Forasartan Saprisartan Tasosartan CYT006-AngQb Azilsartan medoxomil Fimasartan Angiotensin II Candesartan	Diseases 1 Renal tubular dysgenesis	Diseases 2 Renal tubular dysgenesis
Novel Novel	Symbols DBNL and NEURL4	Name 1 drebrin like	Name2 neuralized E3 ubiquitin protein ligase 4	Pathway 1 Caspase-mediated cleavage of cytoskeletal proteins Neurexins and neuroligins Neutrophil degranulation	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols OGT and CCDC77	Name 1 O-linked N-acetylglucosamine (GlcNAc) transferase	Name2 coiled-coil domain containing 77	Pathway 1 HATs acetylate histones RIPK1-mediated regulated necrosis Regulation of necroptotic cell death UCH proteinases Formation of WDR5-containing histone-modifying complexes	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols OGT and ZNF703	Name 1 O-linked N-acetylglucosamine (GlcNAc) transferase	Name2 zinc finger protein 703	Pathway 1 HATs acetylate histones RIPK1-mediated regulated necrosis Regulation of necroptotic cell death UCH proteinases Formation of WDR5-containing histone-modifying complexes	Pathway 2 Generic Transcription Pathway	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols ALDH1A1 and ALDH2	Name 1 aldehyde dehydrogenase 1 family member A1	Name2 aldehyde dehydrogenase 2 family member	Pathway 1 RA biosynthesis pathway Fructose catabolism Ethanol oxidation Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	Pathway 2 Metabolism of serotonin Smooth Muscle Contraction Ethanol oxidation Mitochondrial protein degradation	Drugs 1 NADH Vitamin A Tretinoin 1,4-Dithiothreitol	Drugs 2 NADH Guanidine Disulfiram Daidzin Crotonaldehyde	Diseases 1	Diseases 2 Acute alcohol sensitivity
Novel Novel	Symbols ELOC and WNT7B	Name 1 elongin C	Name2 Wnt family member 7B	Pathway 1 Formation of RNA Pol II elongation complex Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Vif-mediated degradation of APOBEC3G RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation Neddylation Regulation of expression of SLITs and ROBOs Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation Evasion by RSV of host interferon responses Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Pathway 2 WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols POT1 and CPPED1	Name 1 protection of telomeres 1	Name2 calcineurin like phosphoesterase domain containing 1	Pathway 1 Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Pathway 2 Neutrophil degranulation	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols POT1 and MICA	Name 1 protection of telomeres 1	Name2 MHC class I polypeptide-related sequence A	Pathway 1 Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Pathway 2 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Drugs 1	Drugs 2	Diseases 1	Diseases 2 Familial Mediterranean fever (FMF); Familial hereditary periodic fever syndromes
Novel Novel	Symbols POT1 and MYO5C	Name 1 protection of telomeres 1	Name2 myosin VC	Pathway 1 Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols BNIP3 and HPN	Name 1 BCL2 interacting protein 3	Name2 hepsin	Pathway 1	Pathway 2 MET Receptor Activation Signaling by MST1	Drugs 1	Drugs 2 Bentiromide Benzylsulfonic acid CRA_1144 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine	Diseases 1	Diseases 2
Novel	Symbols DPEP1 and KIFBP	Name 1 dipeptidase 1	Name2 kinesin family binding protein	Pathway 1 Synthesis of Leukotrienes (LT) and Eoxins (EX) Aflatoxin activation and detoxification LTC4-CYSLTR mediated IL4 production	Pathway 2	Drugs 1 Cilastatin	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols ELAVL4 and GAP43	Name 1 ELAV like RNA binding protein 4	Name2 growth associated protein 43	Pathway 1	Pathway 2 L1CAM interactions	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols ZBTB5 and JADE2	Name 1 zinc finger and BTB domain containing 5	Name2 jade family PHD finger 2	Pathway 1	Pathway 2 HATs acetylate histones	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CRYBA2 and CALCOCO1	Name 1 crystallin beta A2	Name2 calcium binding and coiled-coil domain 1	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols UBE2D3 and MAEA	Name 1 ubiquitin conjugating enzyme E2 D3	Name2 macrophage erythroblast attacher, E3 ubiquitin ligase	Pathway 1 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TICAM1, RIP1-mediated IKK complex recruitment Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity PINK1-PRKN Mediated Mitophagy Regulation of TNFR1 signaling E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Pathway 2 Regulation of pyruvate metabolism	Drugs 1	Drugs 2 Tetrachlorodecaoxide	Diseases 1	Diseases 2
Novel	Symbols HSPA13 and ST18	Name 1 heat shock protein family A (Hsp70) member 13	Name2 ST18 C2H2C-type zinc finger transcription factor	Pathway 1 Regulation of HSF1-mediated heat shock response	Pathway 2	Drugs 1 Copper	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols HSPA13 and FRY	Name 1 heat shock protein family A (Hsp70) member 13	Name2 FRY microtubule binding protein	Pathway 1 Regulation of HSF1-mediated heat shock response	Pathway 2	Drugs 1 Copper	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CEP70 and ZNF860	Name 1 centrosomal protein 70	Name2 zinc finger protein 860	Pathway 1 Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Pathway 2 Generic Transcription Pathway	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols IRF4 and TRAF2	Name 1 interferon regulatory factor 4	Name2 TNF receptor associated factor 2	Pathway 1 Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Interferon alpha/beta signaling Nuclear events stimulated by ALK signaling in cancer Regulation of MITF-M-dependent genes involved in pigmentation	Pathway 2 Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases Dimerization of procaspase-8 TNF signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation Defective RIPK1-mediated regulated necrosis Regulation of NF-kappa B signaling	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols MTHFS and TSC22D4	Name 1 methenyltetrahydrofolate synthetase	Name2 TSC22 domain family member 4	Pathway 1 Metabolism of folate and pterines	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols AGT and AGTR1	Name 1 angiotensinogen	Name2 angiotensin II receptor type 1	Pathway 1 PPARA activates gene expression Metabolism of Angiotensinogen to Angiotensins Metabolism of Angiotensinogen to Angiotensins Peptide ligand-binding receptors Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events	Pathway 2 Peptide ligand-binding receptors G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Drugs 1 Zinc Copper Sparsentan Zinc acetate	Drugs 2 Valsartan Olmesartan Losartan Candesartan cilexetil Eprosartan Telmisartan Irbesartan Forasartan Saprisartan Tasosartan CYT006-AngQb Azilsartan medoxomil Fimasartan Angiotensin II Candesartan	Diseases 1 Renal tubular dysgenesis	Diseases 2 Renal tubular dysgenesis
Novel	Symbols DBNL and NEURL4	Name 1 drebrin like	Name2 neuralized E3 ubiquitin protein ligase 4	Pathway 1 Caspase-mediated cleavage of cytoskeletal proteins Neurexins and neuroligins Neutrophil degranulation	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols OGT and CCDC77	Name 1 O-linked N-acetylglucosamine (GlcNAc) transferase	Name2 coiled-coil domain containing 77	Pathway 1 HATs acetylate histones RIPK1-mediated regulated necrosis Regulation of necroptotic cell death UCH proteinases Formation of WDR5-containing histone-modifying complexes	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols OGT and ZNF703	Name 1 O-linked N-acetylglucosamine (GlcNAc) transferase	Name2 zinc finger protein 703	Pathway 1 HATs acetylate histones RIPK1-mediated regulated necrosis Regulation of necroptotic cell death UCH proteinases Formation of WDR5-containing histone-modifying complexes	Pathway 2 Generic Transcription Pathway	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols ALDH1A1 and ALDH2	Name 1 aldehyde dehydrogenase 1 family member A1	Name2 aldehyde dehydrogenase 2 family member	Pathway 1 RA biosynthesis pathway Fructose catabolism Ethanol oxidation Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	Pathway 2 Metabolism of serotonin Smooth Muscle Contraction Ethanol oxidation Mitochondrial protein degradation	Drugs 1 NADH Vitamin A Tretinoin 1,4-Dithiothreitol	Drugs 2 NADH Guanidine Disulfiram Daidzin Crotonaldehyde	Diseases 1	Diseases 2 Acute alcohol sensitivity
Novel	Symbols ELOC and WNT7B	Name 1 elongin C	Name2 Wnt family member 7B	Pathway 1 Formation of RNA Pol II elongation complex Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Vif-mediated degradation of APOBEC3G RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation Neddylation Regulation of expression of SLITs and ROBOs Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation Evasion by RSV of host interferon responses Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Pathway 2 WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols POT1 and CPPED1	Name 1 protection of telomeres 1	Name2 calcineurin like phosphoesterase domain containing 1	Pathway 1 Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Pathway 2 Neutrophil degranulation	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols POT1 and MICA	Name 1 protection of telomeres 1	Name2 MHC class I polypeptide-related sequence A	Pathway 1 Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Pathway 2 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Drugs 1	Drugs 2	Diseases 1	Diseases 2 Familial Mediterranean fever (FMF); Familial hereditary periodic fever syndromes
Novel	Symbols POT1 and MYO5C	Name 1 protection of telomeres 1	Name2 myosin VC	Pathway 1 Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2

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