MTHFS and TSC22D4

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MTHFS	TSC22D4
Gene Name		5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)	TSC22 domain family, member 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Cytoplasm
	Molecular Function	ATP Binding Folic Acid Binding 5-formyltetrahydrofolate Cyclo-ligase Activity Metal Ion Binding	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Formate Metabolic Process Tetrahydrofolate Metabolic Process	Transcription, DNA-templated Response To Osmotic Stress Negative Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: TSC22D4	53 interactors: ABLIM1 AES AIFM1 APIP BLZF1 BZRAP1 CCDC146 CCDC33 CCDC42 CCNK CDC23 CDK5R1 CKS2 CLU ENKD1 FRMD6 FXR2 GNB2L1 GOLGA2 GORASP2 KEAP1 KPNA2 KRT40 LBP LMO2 LNX1 LRP2BP MAD2L1 MTHFS MYLIP NIF3L1 NOC4L NRBP1 NRBP2 PCBP1 PIH1D1 PIN1 POLR1C PPL PRKAA1 PRKAA2 PRNP PSMA1 SACS SAT1 SMAD3 SYT17 TEX11 TSC22D1 UBLCP1 ZBTB24 ZMYND10 ZNF580
Entrez ID		10588	81628
HPRD ID		09174	18231
Ensembl ID			ENSG00000166925
Uniprot IDs		P49914	A8MWR6 Q9Y3Q8
PDB IDs		3HXT 3HY3 3HY4 3HY6
Enriched GO Terms of Interacting Partners?			Cell Cycle Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Cell Cycle Negative Regulation Of Cell Death Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Proteolysis Negative Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Cellular Process Cell Cycle Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cytokine Production Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Ubiquitination Negative Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Cell Death Regulation Of Protein Phosphorylation Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Cycle Arrest Negative Regulation Of Signal Transduction Nitrogen Compound Metabolic Process Regulation Of Energy Homeostasis Negative Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Glycolytic Process Cellular Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		1r chromatography confirm conserved depend detect difficult egf grb2 jak mediator methenyltetrahydrofolate mimicking motif p85alpha partners phosphopeptide phosphopeptides phosphotyrosine pi3 purify recruited simple synthetase synthetic technically transduction transformation transient	ablation cachectic cachexia clone deprivation diminished hepatic hepatocytes hypertriglyceridemia hypo hypobetalipoproteinemia lipids lipogenic livers mammals metabolic mimicking output proper rationale rescued secretion storage transforming triggers vldl wasting
Tagcloud (Difference) ?		1r chromatography confirm conserved depend detect difficult egf grb2 jak mediator methenyltetrahydrofolate motif p85alpha partners phosphopeptide phosphopeptides phosphotyrosine pi3 purify recruited simple synthetase synthetic technically transduction transformation transient	ablation cachectic cachexia clone deprivation diminished hepatic hepatocytes hypertriglyceridemia hypo hypobetalipoproteinemia lipids lipogenic livers mammals metabolic output proper rationale rescued secretion storage transforming triggers vldl wasting
Tagcloud (Intersection) ?		mimicking