DBNL and NEURL4

Number of citations of the paper that reports this interaction (PubMedID 17353931)
53

Data Source:
HPRD (two hybrid, in vivo)

		DBNL	NEURL4
Description		drebrin like	neuralized E3 ubiquitin protein ligase 4
Image
GO Annotations	Cellular Component	Golgi Membrane Ruffle Podosome Extracellular Region Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell Cortex Postsynaptic Density Membrane Lamellipodium Dendrite Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Secretory Granule Lumen Cell Projection Neuron Projection Perikaryon Synapse Extracellular Exosome Anchoring Junction Presynapse Postsynapse Glutamatergic Synapse Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Cytoplasm Mitochondrion Centriole Cytoskeleton
	Molecular Function	Actin Binding Protein Binding Enzyme Activator Activity Protein Domain Specific Binding Cadherin Binding Actin Filament Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton	Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Adaptive Immune Response Immune System Process Endocytosis Synapse Assembly Rac Protein Signal Transduction Neuron Projection Morphogenesis Membrane Organization Podosome Assembly Postsynaptic Actin Cytoskeleton Organization	Spermatogenesis Mitochondrial DNA Repair
Pathways		Caspase-mediated cleavage of cytoskeletal proteins Neurexins and neuroligins Neutrophil degranulation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Appendicular lean mass ( 33097823) Systemic lupus erythematosus ( 33536424) Type 1 diabetes ( 34012112)
Interacting Genes		14 interacting genes: ACD CASP3 HOMER1 MAP4K1 NEURL4 OGT POT1 SH2D4A SH3BP2 SHANK3 SYK TERF1 TERF2IP ZAP70	2 interacting genes: DBNL MAP1LC3A
Entrez ID		28988	84461
HPRD ID		06588	13894
Ensembl ID		ENSG00000136279	ENSG00000215041
Uniprot IDs		B4DUF9 Q9UJU6	Q96JN8
PDB IDs		1X67	2E63
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance G-rich Strand Telomeric DNA Binding Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Via Telomerase DNA Biosynthetic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Beta Selection Regulation Of Telomere Maintenance Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Organization Negative Regulation Of DNA Metabolic Process Telomere Assembly Regulation Of Telomere Maintenance Via Telomerase Phosphotyrosine Residue Binding Phosphatase Binding Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Establishment Of Protein Localization To Telomere Chromosome, Telomeric Region Negative Regulation Of Cellular Component Organization Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Protection From Non-homologous End Joining At Telomere Neuron Spine Telomeric D-loop Disassembly Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Telomere Maintenance In Response To DNA Damage Positive Regulation Of DNA Metabolic Process T Cell Receptor Complex Positive Regulation Of Signal Transduction Chromosome Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Alpha-beta T Cell Proliferation DNA Metabolic Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling	Postsynaptic Cytoskeleton Organization Structural Constituent Of Postsynaptic Actin Cytoskeleton Rac Protein Signal Transduction Postsynaptic Actin Cytoskeleton Organization Glutamatergic Synapse Podosome Assembly Response To Iron(II) Ion Response To Oxygen-glucose Deprivation Cellular Response To Oxygen-glucose Deprivation Phosphatidylethanolamine Binding SMAD Protein Signal Transduction Autolysosome Cellular Response To Nitrogen Starvation Cellular Response To Copper Ion Response To Lead Ion P38MAPK Cascade Organelle Assembly Clathrin-coated Vesicle Membrane Response To Iron Ion Response To Copper Ion Intracellular Signaling Cassette Cytoplasmic Vesicle Podosome
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